t widespread for many genetic diseases, he adds, currently emerging technologies will make it feasible to diagnose nearly all genetic diseases early in gestation within the next 10 years. "The combination of data from the Human Genome Project, improvements in molecular diagnoses, gene chip technology, and the ability to do molecular diagnoses of fetal cells or fetal DNA within the mother's blood, all support early gestational diagnosis of genetic disease," says Dr. Flake.

Dr. Flake cautions that the clinical applications may be years away, but based on these results, he will further investigate stem cell transplantation in mice and then in larger animals, with the goal of translating the approach to treatments for people.

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Contact: John Ascenzi
ascenzi@email.chop.edu
215-590-7332
Children's Hospital of Philadelphia
6-Nov-2002

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