HOME >> MEDICINE >> NEWS
Presence of gene mutation tightly linked to drug effectiveness in lung cancer

Mutation of a gene involved in non-small cell lung cancer (NSCLC) increases the likelihood that the drug gefitinib (IressaTM) will show a beneficial response, researchers at the Dana-Farber Cancer Institute, the National Cancer Institute (NCI) part of the National Institutes of Health and two other institutions announced today in the online version of Science*. Previously, gefitinib had been shown to cause tumor regression in certain patients, but researchers had not been able to predict which patients would be responsive to the drug. With this discovery, doctors will be able to select those lung cancer patients who could most benefit from gefitinib and may identify additional patients with other types of cancer who may respond to similar treatments.

The mutation discovered was in the epidermal growth factor receptor (EGFR), a gene that codes for an enzyme in the tyrosine kinase family of proteins. Tyrosine kinases are a class of enzymes involved in cellular signaling that have been shown to undergo mutations in various cancers. Inhibition of this type of enzyme has recently been a focus for scientists, but gefitinib had not been as effective as some had expected based on earlier clinical trials conducted in Japan.

The gene mutations identified in this study cause the kinase to be overactive. The sensitivity to gefitinib in both patients entered into a clinical trial and to tumor cells grown in a lab was shown to be highly correlated with the presence of tumors that contained these EGFR mutations. While this type of drug sensitivity was shown earlier for the drug imatinib (GleevecTM), which is most effective against certain leukemias and gastrointestinal stromal tumors that possess specific genetic mutations, this is the first demonstration of a targeted therapy in a common adult malignancy.

"One of the more striking results we found in this study was the difference in response between Japanese and A
'"/>

Contact: NCI Press Office
301-496-6641
NIH/National Cancer Institute
29-Apr-2004


Page: 1 2

Related medicine news :

1. Presence of certain eye disorders linked with poorer survival rates
2. Non-invasive and invasive breast cancers share the same genetic mutations
3. Both inherited traits and tumor mutations affect response to treatment of leukemia
4. LRRK2 gene mutation causes Parkinsons disease in several families
5. Small increases or blips in HIV levels do not signal mutations leading to drug-resistant HIV
6. Gene mutations responsible for childhood cataracts discovered
7. Gene mutations predict which lung cancers will respond to Iressa
8. Breast cancer patients with BRCA1 or 2 mutations twice as likely to have double mastectomy
9. Breast cancer patients with BRCA 1/2 mutations twice as likely to choose double mastectomy
10. Mayo Clinic researchers discover gene mutations that ignore stress, lead to heart failure
11. Genetic mutation linked to infant lung disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/11/2019)... LONDON (PRWEB) , ... September 11, 2019 , ... ... is ever-evolving, although many industries have struggled to solve injury risks which lead ... the organisation, the wearable technology solution developed by the team at Soter ...
(Date:9/11/2019)... ... September 11, 2019 , ... Global Education Group (Global), a ... provider, is the official accreditor for PAINWeek, the largest US pain conference for ... as it has done for the past ten years. In addition, the Global ...
(Date:9/11/2019)... ... 11, 2019 , ... GRM Information Management, a leading provider ... Information Conference in Chicago, Illinois September 14 to 18. , AHIMA conference ... healthcare information management solutions . , Built around their robust, cloud-based content ...
(Date:9/11/2019)... ... 2019 , ... Autopsies don’t lie. They report the causes of death ... permanently harms the heart. It increases risks of heart attack and death. ... the damage occurs. , An August 1, 2019 article in U.S. ...
(Date:9/11/2019)... BAR, Calif. (PRWEB) , ... September 11, 2019 , ... ... Ahimi. This plant-based poke bowl option appeals to vegans, vegetarians, pescatarians and poke ... soy sauce, sugar, and sesame oil. With its meaty texture similar to tuna, ...
Breaking Medicine News(10 mins):
(Date:9/17/2019)... ... , ... Summer is a time for barbecues, parties and picnics and lots of delicious food ... Douglas Ng, family dentist in San Luis Obispo has some tips for healthy ... popsicles and ice-filled cold drinks to go along with the hot dogs, hamburgers, corn on ...
(Date:9/17/2019)... ... 2019 , ... Dr. Babis Rammos, a renowned plastic surgeon ... Beauty Network, well known for its exclusive and luxurious lifestyle publication Haute Living ... newest addition to the Haute Beauty members-only network. , Haute Beauty offers a ...
(Date:9/14/2019)... ... September 13, 2019 , ... ... in Montreal provided a plethora of breakthrough research studies including several cancer ... to detect breast cancer, response prediction of cancer immunotherapies and whole body, ...
Breaking Medicine Technology:
Cached News: