HOME >> MEDICINE >> NEWS
Presence of gene mutation tightly linked to drug effectiveness in lung cancer

merican patients, which raises the question of genetic variation in different ethnic, cultural, and geographic groups to this particular drug," said Bruce E. Johnson, M.D., Dana-Farber Cancer Institute, who led the Lung Cancer Biology Section at NCI before leaving for Dana-Farber.

To conduct the study, researchers examined 58 lung cancer tumors from Japan (Nagoya City University Hospital) and 61 tumors from the United States (Harvard Medical School). They also examined additional tumors from U.S. patients who had demonstrated a response to gefitinib. The presence of EGFR mutations and the best clinical response to gefitinib therapy occurred most frequently in women, non-smokers, and in patients with a certain type of lung cancer called adenocarcinoma.

Gene mutations were seen in 26 percent of Japanese NSCLC cancer patients vs. only 2 percent of American patients. Japanese women with adenocarcinoma showed the highest percentage of EGFR mutations (57 percent) and also showed the best clinical response to gefitinib. Lung cancer is the leading cause of cancer death in the United States and worldwide for both men and women.

"This is another example of successfully exploiting our ever-increasing understanding of the genetic aberrations of cancer," said Andrew C. von Eschenbach, M.D., director, NCI. Understanding how to maximize the benefits of anti-EGFR treatments should improve the outcome for many patients with lung cancer. In addition, the larger percentage of EGFR mutations in patients from Japan compared to the United States is striking and raises many unanswered questions, suggesting new avenues for basic research, as well as new considerations in the design of clinical trials.


'"/>

Contact: NCI Press Office
301-496-6641
NIH/National Cancer Institute
29-Apr-2004


Page: 1 2

Related medicine news :

1. Presence of certain eye disorders linked with poorer survival rates
2. Non-invasive and invasive breast cancers share the same genetic mutations
3. Both inherited traits and tumor mutations affect response to treatment of leukemia
4. LRRK2 gene mutation causes Parkinsons disease in several families
5. Small increases or blips in HIV levels do not signal mutations leading to drug-resistant HIV
6. Gene mutations responsible for childhood cataracts discovered
7. Gene mutations predict which lung cancers will respond to Iressa
8. Breast cancer patients with BRCA1 or 2 mutations twice as likely to have double mastectomy
9. Breast cancer patients with BRCA 1/2 mutations twice as likely to choose double mastectomy
10. Mayo Clinic researchers discover gene mutations that ignore stress, lead to heart failure
11. Genetic mutation linked to infant lung disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... Genesis Chiropractic ... announced today the launch of its integrated, HIPAA compliant, telehealth solution, available to ... practice in under 90 seconds. , According to the U.S. Department of ...
(Date:8/31/2020)... MAUI, Hawaii (PRWEB) , ... August 31, 2020 , ... A Cure for Covid-19 “PTS” ... most people on the planet are in a state of panic, experiencing deep anxiety, immense ... , Right now, a solution is timely when most people on the planet are experiencing ...
(Date:8/29/2020)... ... ... When professor and author Randy Pausch was diagnosed with pancreatic cancer, he accepted his ... however, he put together a final lecture in Carnegie Hall in which he offered ... and turned it into something that inspired millions of people worldwide. This inclination to ...
(Date:8/28/2020)... ... 28, 2020 , ... With in-person gluten-free events being canceled ... the specialty-diet community connect with great, gluten-free brands. At the Online Nourished ... with brands & watch over 50 educational classes... all online from the comfort ...
(Date:8/27/2020)... ... August 27, 2020 , ... Walk-in Dermatology’s SK-IN Medical ... its Greenvale, New York location. , Loren received her New York esthetic ... certified in chemical peels, microdermabrasion, Hydrafacial MD, dermaplaning, facial lymphatic, and various laser ...
Breaking Medicine News(10 mins):
(Date:8/28/2020)... ... 28, 2020 , ... Dr. Mark Surrey has been in practice for ... a clinical professor in the Department of OBGYN at UCLA’s David Geffen School of ... Coast Reproductive Society and is a Clinical Director of Fellowship Training for UCLA & ...
(Date:8/27/2020)... ... ... Bleep LLC, maker of the DreamPort mask-less CPAP solution, announced today that ... , “In my line of work, a good night of sleep is critical to ... a Bleeping no brainer for me,” said Jensen. “From the moment I started using ...
(Date:8/26/2020)... DIEGO (PRWEB) , ... August 26, 2020 , ... AseptiScope, ... 2020 Infection Control Company of the Year by MedTech Outlook. , “AseptiScope ... Officer. “For the first time, clinicians who wear gloves on their hands, goggles on ...
Breaking Medicine Technology:
Cached News: