Process may help scientists find new antibacterial drugs

The hunt for new antibiotic drugs, driven by emerging diseases and growing bacterial resistance to existing antibiotics, may get a little easier thanks to a new process for making compounds that contain a key bacteria-stopping structure.

The process, developed by a group of researchers led by Thomas Lectka, associate professor of chemistry at The Johns Hopkins University, will make it less expensive to create and easier to test compounds belonging to a class of drugs known as beta-lactams. Penicillin and a number of other infection-fighters are beta-lactams, but bacterial resistance has reduced the usefulness of an increasing number of these drugs.

Lectka, who describes the new process in a report in the online version of The Journal of the American Chemical Society [scroll down to Aug. 2], hopes his work will facilitate the creation of new beta-lactam drugs.

"Beta-lactams have been critical tools for fighting the spread of bacterial infections in the past, and they could be so again," Lectka says. "It's also important to note that while beta-lactams have traditionally been used as antibiotics, they have recently found use in treating patients with conditions ranging from arthritis to HIV."

Beta-lactams's distinguishing characteristic is a high-energy ring of three carbon atoms and one nitrogen atom known as a beta-lactam ring.

"This ring wants to pop open," Lectka explains, "but it doesn't typically do that until a bacterial enzyme comes along and mistakes it for a substrate, a material chemically modified by the enzyme. When the enzyme uses the beta-lactam, the ring snaps open, disabling the enzyme and effectively killing the bacteria."

After decades of overuse of penicillin and other popular antibiotics, though, many bacteria have developed enzymes that disable the beta-lactam rings first. Those enzymes are

Contact: Michael Purdy
Johns Hopkins University

Page: 1 2 3

Related medicine news :

1. Processing with flavonoids can mean tastier, heart healthy food
2. Process used to judge asylum seekers is questioned
3. University Of Pittsburgh Researchers Identify Immune System Process That Could Halt Progress Of Cirrhosis In Humans
4. Neurobiologists Show How The Brain Processes Signals From Pheromones
5. OHSU scientists test medication to treat involuntary weight loss
6. Earlier use of prostate cancer vaccines urged by Hopkins scientists
7. Tobacco industry pays scientists to challenge secondhand smokes link to infant death risk
8. Schepens scientists regenerate optic nerve for the first time
9. OHSU scientists develop MRI approach to improve breast cancer detection
10. UCLA neuroscientists pinpoint new function for mirror neurons
11. Jefferson scientists uncover potential trigger of diabetic kidney disease

Post Your Comments:

(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: