Process may help scientists find new antibacterial drugs

The hunt for new antibiotic drugs, driven by emerging diseases and growing bacterial resistance to existing antibiotics, may get a little easier thanks to a new process for making compounds that contain a key bacteria-stopping structure.

The process, developed by a group of researchers led by Thomas Lectka, associate professor of chemistry at The Johns Hopkins University, will make it less expensive to create and easier to test compounds belonging to a class of drugs known as beta-lactams. Penicillin and a number of other infection-fighters are beta-lactams, but bacterial resistance has reduced the usefulness of an increasing number of these drugs.

Lectka, who describes the new process in a report in the online version of The Journal of the American Chemical Society [scroll down to Aug. 2], hopes his work will facilitate the creation of new beta-lactam drugs.

"Beta-lactams have been critical tools for fighting the spread of bacterial infections in the past, and they could be so again," Lectka says. "It's also important to note that while beta-lactams have traditionally been used as antibiotics, they have recently found use in treating patients with conditions ranging from arthritis to HIV."

Beta-lactams's distinguishing characteristic is a high-energy ring of three carbon atoms and one nitrogen atom known as a beta-lactam ring.

"This ring wants to pop open," Lectka explains, "but it doesn't typically do that until a bacterial enzyme comes along and mistakes it for a substrate, a material chemically modified by the enzyme. When the enzyme uses the beta-lactam, the ring snaps open, disabling the enzyme and effectively killing the bacteria."

After decades of overuse of penicillin and other popular antibiotics, though, many bacteria have developed enzymes that disable the beta-lactam rings first. Those enzymes are

Contact: Michael Purdy
Johns Hopkins University

Page: 1 2 3

Related medicine news :

1. Processing with flavonoids can mean tastier, heart healthy food
2. Process used to judge asylum seekers is questioned
3. University Of Pittsburgh Researchers Identify Immune System Process That Could Halt Progress Of Cirrhosis In Humans
4. Neurobiologists Show How The Brain Processes Signals From Pheromones
5. OHSU scientists test medication to treat involuntary weight loss
6. Earlier use of prostate cancer vaccines urged by Hopkins scientists
7. Tobacco industry pays scientists to challenge secondhand smokes link to infant death risk
8. Schepens scientists regenerate optic nerve for the first time
9. OHSU scientists develop MRI approach to improve breast cancer detection
10. UCLA neuroscientists pinpoint new function for mirror neurons
11. Jefferson scientists uncover potential trigger of diabetic kidney disease

Post Your Comments:

(Date:8/31/2020)... YORK (PRWEB) , ... August 31, 2020 , ... ... nation’s largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving ... patient services – today announced the 10th Anniversary of Blood Cancer Awareness Month ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... 31, 2020 , ... Dr. Chang has over 20 years ... other developmental disabilities, as well as supporting staff in caring for patients and ... consultation, and staff development. She joined the company in 2015 as Chief of ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... to a customized Lighthouse Health & Wellness mobile app and web-portal. NCPCV received ... Motorola Solutions Foundation awards grants each year to organizations, such as Destination Imagination, ...
(Date:8/27/2020)... ... 27, 2020 , ... Walk-in Dermatology’s SK-IN Medical Aesthetics Center ... New York location. , Loren received her New York esthetic license in ... chemical peels, microdermabrasion, Hydrafacial MD, dermaplaning, facial lymphatic, and various laser procedures. Loren ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... 2020 , ... Trella Health, the leading source of provider ... CRM, marketing automation, and contact center solutions for senior living communities and post-acute ... performance intelligence data and insights into Enquire’s CRM solution to serve as a ...
(Date:8/26/2020)... ... August 26, 2020 , ... AseptiScope, a privately funded ... Company of the Year by MedTech Outlook. , “AseptiScope is pleased to ... first time, clinicians who wear gloves on their hands, goggles on their eyes, covers ...
(Date:8/26/2020)... ... 2020 , ... As the U.S. struggles in its 6th month of fighting ... Wear a mask, keep your distance, wash your hands. Prevention is the best tool ... in 1977, “How much better it is to prevent disease than to cure it.” ...
Breaking Medicine Technology:
Cached News: