Progress In Cancer-Vaccine Studies: Simpler, Safer Approach Producing Encouraging Results

In one of the most encouraging cancer vaccine therapy trials to date, researchers from the University of Chicago and Genetics Institute (Cambridge, MA) have demonstrated that their faster, simpler and safer approach to treatment may also be more effective than previous cancer vaccines. By giving melanoma patients the immune stimulant interleukin-12, the researchers were able to bypass the costly and difficult process of growing large populations of dendritic cells in culture and returning them to the patient, a process that takes weeks.

Instead, they extracted circulating white blood cells, exposed them to either of two markers commonly seen on melanoma cells, and returned them to the patient -- a process that takes only a few hours. Then they gave the patients different doses of IL-12 over the next five days to boost the immune response. The treatment cycle was repeated three times.

"Using total white blood cells instead of cultured dendritic cells was somewhat heretical," explains Thomas Gajewski, M.D., Ph.D., assistant professor of pathology and medicine at the University of Chicago and director of the study, "but our results indicate that it can be just as effective yet avoids the risks, delays and complexity associated with growing dendritic cells in culture."

The key finding, presented May 17th at the annual meeting of the American Society of Clinical Oncology in Atlanta, was the surprise discovery that moderate doses of IL-12 were far more effective at stimulating an anti-cancer response than higher, more-toxic doses.

Phase-1 clinical trials are usually designed to determine the maximum tolerated dose of a new drug, but this trial indicated that the best dose was about one tenth of the maximum dose -- suggesting that dosing trials of biologic therapies require a radically different design. At moderate doses, IL-12's most serious side effects were tenderness at the injection site, tiredness and mild fever. Higher doses were more toxic and m

Contact: John Easton
University of Chicago Medical Center

Page: 1 2

Related medicine news :

1. Progress in cardiovascular disease
2. Progress shown in death rates from four leading cancers decline in overall mortality has slowed
3. Initial Avon/NCI breast cancer research grants awarded in Progress for Patients awards program
4. Progress and future directions for management of hepatitis C
5. Progress toward a vaccine to fight cocaine addiction is reported
6. Stress Speeds Progression To AIDS
7. Jefferson Researchers Report Progress In Using Vaccinia-Based Vaccine For Melanoma
8. University Of Pittsburgh Researchers Identify Immune System Process That Could Halt Progress Of Cirrhosis In Humans
9. Experts Meet In Canada To Discuss Vaccine Progress
10. Despite Progress, More Action Needed To Protect Medical Students From Exposure To Disease Through Accidental Needlesticks, UCSF Study Finds
11. Setbacks To Health Progress In Central America

Post Your Comments:

(Date:9/1/2020)... ... September 01, 2020 , ... Board ... in Glendale. While the office will be the first to bear her name, ... buttock augmentation (Brazilian butt lift), as well as rhinoplasty, facial rejuvenation, and many ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... are joining biomedical engineers from Carnegie Mellon University (CMU) to develop a new ... who have undergone open heart surgery. , The AGH/CMU team was recently awarded ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... management solution for chiropractors, announced today the launch of its integrated, HIPAA compliant, ... start running their virtual practice in under 90 seconds. , According to ...
(Date:8/31/2020)... ... 2020 , ... In an effort to give back to the community in ... each hotel room booked with a special new rate code to benefit children and ... effective immediately. Donations will be applied to any room type, any time, now ...
(Date:8/28/2020)... ... August 28, 2020 , ... WHAT , Hespiro™ ... patients with respiratory conditions, including COVID-19, while reducing the need for scarce mechanical ... captures exhaled gas and scrubs it free of carbon dioxide in a completely ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... Colo. (PRWEB) , ... September 03, 2020 , ... ... Colorado at Boulder’s Vance Lab ( https://www.colorado.edu/lab/vance/masks ), an aerosol and engineering lab, ... can provide better protection against the COVID-19 virus than many other masks. Q&J ...
(Date:9/2/2020)... ... September 02, 2020 , ... Rigaku Analytical ... roundtable discussion among industry professionals about successes and challenges of making changes to ... Pharmaceutical Review and will take place on October 15, 2020 at 10:00am ...
(Date:9/1/2020)... ... 01, 2020 , ... Agilent, a global leader in life ... Technology Virtual Symposium 2020 (ASTVS 2020) on September 10-11, opening at 10:00am ... webinars and Networking sessions, with a vast array of on-demand presentations to enjoy ...
Breaking Medicine Technology:
Cached News: