HOME >> MEDICINE >> NEWS
Promising New Drug Uses Antibody Targeted Chemotherapy To Fight Leukemia

Scientists presented data here today at the 40th Annual Meeting of the American Society of Hematology (ASH), demonstrating how a breakthrough new experimental compound, known as CMA-676, uses an antibody connected to chemotherapy molecules to help patients fight a virulent and often fatal form of cancer - acute myelogenous leukemia (AML). The data appeared to confirm that this novel treatment method -- "antibody-targeted chemotherapy" -- shows promising efficacy and a more tolerable side effect profile than current chemotherapy treatments.

AML is a life-threatening disease in which certain white blood cells become cancerous and rapidly replace and destroy normal bone marrow and blood cells. AML is among the most serious forms of adult leukemia, with a relatively high fatality rate. Most patients require intensive chemotherapy to achieve complete remission, and some also must undergo bone marrow transplants. Up to half of patients with AML, even after such intensive treatment, have residual leukemic cells or experience a relapse.

Because current chemotherapy drugs to treat AML are non-specific - harming good as well as bad cells - patients who are receiving standard chemotherapy become very sick. Researchers at the Fred Hutchinson Cancer Research Center, in collaboration with scientists from thirteen leading leukemia centers including, University of Chicago Medical Center, MD Anderson Cancer Center and The University of Pennsylvania Cancer Center, are working with Wyeth-Ayerst Research and Celltech PLC to study CMA-676, an antibody-drug conjugate that delivers treatment directly to the leukemia cells.

The antibody is engineered to carry just a few molecules of a new and extremely potent chemotherapy agent - from the calicheamicin family -- to selectively destroy leukemic blast cells. This approach may spare primary and vital bone marrow cells that are responsible for regenerating normal blood cells once the leukemia cells are destr
'"/>

Contact: Susan Edmonds
sedmonds@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
7-Dec-1998


Page: 1 2

Related medicine news :

1. Promising new strategy for Swedish medical research
2. Promising treatments for Huntingtons disease identified in UCI study
3. Promising results for malaria vaccine trial
4. Promising diagnostic test for sleeping sickness
5. Promising new treatment options for people with co-existing alcohol-use and psychiatric disorders
6. Promising drug fails to thwart fatal lung disease in large trial
7. Promising drug proves ineffective as treatment for hearing loss
8. Promising West Nile virus vaccine protects monkeys
9. Promising new treatment preserves bone mass in mice; May help women and men with osteoporosis
10. Promising vaccine may provide long-lasting protection against malaria
11. Promising new research on schizophrenia causes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/11/2019)... ... , ... Autopsies don’t lie. They report the causes of death as ... harms the heart. It increases risks of heart attack and death. Autopsies ... damage occurs. , An August 1, 2019 article in U.S. News ...
(Date:9/11/2019)... , ... September 10, 2019 , ... ... the team. Dr. Hesano is an understanding, caring and highly skilled Obstetrician/Gynecologist. ... obstetrical medicine. Dr. Hesano strives to ensure that each visit is comfortable, patient-focused, ...
(Date:9/9/2019)... ... September 09, 2019 , ... ST Engineering ... International will integrate the iDirect iQ 200 Board and the latest Evolution® software ... for first responders. The iQ 200 Board will enable the HARRIER solution to ...
(Date:9/9/2019)... ... September 09, 2019 , ... On ... organization-wide policy focusing on a diabetes-language movement (#LanguageMatters) to include oral and written ... non-judgmental, free from stigma, respectful and inclusive, empowering, and person-centered (to include care ...
(Date:9/8/2019)... ... 2019 , ... The reviews from patients of ABM Medical Clinic who have ... and pain free fat loss system, has patients booking their sessions and recommending this ... uses state of the art technology incorporating radio frequency and heat to rid the ...
Breaking Medicine News(10 mins):
(Date:9/11/2019)... ... September 11, 2019 , ... HOLLOWAY AMERICA, a leading manufacturer ... beverage to pharma and chemical, recently announced it will showcase its problem-solving vessels and ... , HOLLOWAY AMERICA’s first stop will be at ISPE San Diego’s 27th Life ...
(Date:9/11/2019)... ... 2019 , ... Pivot Point Consulting is excited to announce ... Partnerships team. Maris brings two decades of experience with Cerner—leading both sales ... as a Technical Implementation Leader representing the Technical Engagement Leader community. , Pivot ...
(Date:9/9/2019)... , ... September 09, 2019 , ... ... Shoreline Periodontics & Dental Implants host the latest course in their Synergy Study ... Mystic, CT and features guest speaker Dr. Peter Barndt. Synergy Study Club brings ...
Breaking Medicine Technology:
Cached News: