HOME >> MEDICINE >> NEWS
Promising diagnostic test for sleeping sickness

Around half a million people a year in sub-Saharan Africa are affected by sleeping sickness (human African trypanosomiasis). The disease is fatal in humans if not treated with chemotherapy; however, adverse effects of drug treatment and an increase in drug resistance underline the importance of establishing an accurate diagnostic test for the disease.

In this week's issue of THE LANCET, Sanjeev Krishna from St George's Hospital Medical School, London, UK, and colleagues assessed whether mass spectrometry could identify a characteristic protein marker for individuals known to have sleeping sickness. Blood from 85 such individuals was compared with blood samples from 146 patients who had other parasitic or non-parasitic infections. Half the samples were used to calibrate the diagnostic test; the other half served as the main research sample. Mass spectrometry created distinct blood proteomic signatures characteristic of human African trypanosomiasis. The test was shown to have a sensitivity of 100% and a specificity of 986% (ie, importantly, a very low chance of recording 'false-positive' results).

Professor Krishna comments: "We report the accurate diagnosis of an infection using proteomic signature analysis. The same approach could, equally, be used to improve the diagnostic accuracy of other infections, such as tuberculosis, which can be difficult to detect using conventional tests".

In an accompanying Commentary (p 1337), Marinus F W te Pas from Wageningen University, Netherlands, states: "methods driven by high technology often have the disadvantages of being expensive and restricted to highly specialised laboratories, and hence are not applicable in the field. But, as the current study suggests, such diagnostic methods should be a starting point to develop new diagnostic methods for the field".


'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212- 633-3810
Lancet
22-Apr-2004


Page: 1

Related medicine news :

1. Promising new strategy for Swedish medical research
2. Promising treatments for Huntingtons disease identified in UCI study
3. Promising results for malaria vaccine trial
4. Promising new treatment options for people with co-existing alcohol-use and psychiatric disorders
5. Promising drug fails to thwart fatal lung disease in large trial
6. Promising drug proves ineffective as treatment for hearing loss
7. Promising West Nile virus vaccine protects monkeys
8. Promising new treatment preserves bone mass in mice; May help women and men with osteoporosis
9. Promising vaccine may provide long-lasting protection against malaria
10. Promising new research on schizophrenia causes
11. UI Study Suggests Promising Treatment For Diabetic Pregnancies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers care ... have a waiver for care if the client has a cognitive impairment diagnosis. ... for care, is often waived, so the benefits from their insurance start immediately,” said ...
(Date:10/13/2017)... ... 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out ... free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting ... children of all ages; it is a non-competitive, non-timed event, which is all about ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Agile Software Development, has been awarded a contract by the Center for Medicare ... (BPA) aims to accelerate the enterprise use of Agile methodologies in a consistent ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company ... of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every ... meet the highest standard. , These products are also: Gluten Free, Non-GMO, ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... -- Cohen Veterans Bioscience and Early Signal Foundation announce ... home sensors for real-time monitoring of patients with trauma-related ... organization focused on disruptive health solutions for rare disorders ... to record and integrate behavioral, cognitive, physiological and contextual ... ...
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global ... that its MyDario product is expected to appear on The Dr. Oz ... Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked ... The segment features ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
Breaking Medicine Technology:
Cached News: