HOME >> MEDICINE >> NEWS
Promising drug proves ineffective as treatment for hearing loss

Researchers have demonstrated that Methotrexate, a promising drug to treat hearing loss in patients with autoimmune inner ear disease (AIED), proved no more effective than placebo in a recently concluded four-year study.

In findings published in the October 8, 2003 issue of the Journal of the American Medical Association (JAMA), a team headed by University of California, San Diego (UCSD) Professor and Chief of Otolaryngology Head and Neck Surgery, Jeffrey Harris, M.D., also noted that the steroid Prednisione proved very effective in both stabilizing and helping over 57% of the AIED patients regain hearing.

"AIED is a rapidly progressive form of sensorineural hearing loss. If left untreated or treated inadequately, AIED can result in profound deafness," says Harris. "We've known for some time that steroids are effective in improving hearing loss in AIED."

However, he noted, the many side effects associated with maintaining prolonged steroid therapy has led to the search for more effective drugs to treat this condition over the long term. And, once the steroids are withdrawn, the hearing loss may reoccur. Methotrexate has been considered a promising drug to treat AIED, due to its long track record as an effective anti-inflammatory, says Harris, improving patients with rheumatoid arthritis, an autoimmune disease that affects the body's joints. Since AIED is also an autoimmune condition, Harris says researchers hoped the drug would have the same therapeutic effect.

AIED starts with the rapid appearance of bilateral, fluctuating and progressive, asymmetrical sensorineural hearing loss. Patients show hearing loss and usually tinnitus. Several blood tests are now being tested to identify patients with AIED. Approximately two-thirds of patients exhibit this autoimmune disease in their ears. In the other third, patients may have some of the well-known rheumatic diseases occurring concurrently with the hearing loss.

"In earlier s
'"/>

Contact: Jeffree Itrich
jitrich@ucsd.edu
619-543-6163
University of California - San Diego
7-Oct-2003


Page: 1 2

Related medicine news :

1. Promising new strategy for Swedish medical research
2. Promising treatments for Huntingtons disease identified in UCI study
3. Promising results for malaria vaccine trial
4. Promising diagnostic test for sleeping sickness
5. Promising new treatment options for people with co-existing alcohol-use and psychiatric disorders
6. Promising drug fails to thwart fatal lung disease in large trial
7. Promising West Nile virus vaccine protects monkeys
8. Promising new treatment preserves bone mass in mice; May help women and men with osteoporosis
9. Promising vaccine may provide long-lasting protection against malaria
10. Promising new research on schizophrenia causes
11. UI Study Suggests Promising Treatment For Diabetic Pregnancies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/16/2018)... ... ... The Colorado Rural Health Center (CRHC) is proud to recognize the innovation, quality ... Rural Health Day 2018. National Rural Health Day falls on the third Thursday in ... over 60 million people across the nation. , This year, CRHC is celebrating ...
(Date:11/16/2018)... ... November 16, 2018 , ... Nutrex Research ... care product called Lipo-6 Defining Gel . Utilizing TopiSorbTM Technology, this gel quickly ... cellulite and fatty deposits have met their match. , Maximizing fat loss by ...
(Date:11/16/2018)... ... November 16, 2018 , ... ... Framework (RMF) approved, cloud-based Force Protection and Emergency Management solutions who announced today ... contract to provide these services Army-wide. , Under the contract, E-9 will expand ...
(Date:11/16/2018)... ... 16, 2018 , ... OnlineMasters.com, an industry-leading educational research organization, ... 2019. They have identified the top programs in the nation that are the ... , Leveraging an exclusive data set comprised of interviews and surveys from current ...
(Date:11/15/2018)... ... November 15, 2018 , ... Modern Acupuncture™, the first franchise ... in an accessible and affordable delivery, is now open in Bothell. Modern Acupuncture ... all across the country. , Located at 1427 228th Street in the Canyon ...
Breaking Medicine News(10 mins):
(Date:11/16/2018)... ... 2018 , ... Mytonomy, a leader in virtual digital health ... the usability of and satisfaction with Mytonomy’s video-based microlearning platform among people living ... the 18th Annual Diabetes Technology Society Meeting, showed that patients were highly satisfied ...
(Date:11/16/2018)... , ... November 16, 2018 , ... ... CBD products, is thrilled to announce the launch of its newly redesigned website. ... understanding of the company's mission and products. The newly redesigned website will be ...
(Date:11/16/2018)... ... November 16, 2018 , ... Strategic Radiology welcomes its ... for the nationwide coalition of independent practices. , NVRA is based in Waterbury, ... The 13-radiologist subspecialized practice is a member of the Connecticut Imaging Alliance, a ...
Breaking Medicine Technology:
Cached News: