Promising new research on schizophrenia causes

Research by a prominent neuroscientist at UIC is providing new clues to the molecular origins of schizophrenia, a devastating mental illness that afflicts nearly 2.5 million Americans.

Erminio Costa, a member of the National Academy of Sciences and scientific director of UIC's Psychiatric Institute, is studying a chemical found in the brain called reelin. Reelin plays a role in correctly positioning and aligning neurons in the developing brain. It is also present in certain areas of the adult brain, including the cerebral cortex, the region responsible for higher mental functions like language and problem solving.

In a postmortem study of the brains of schizophrenics, obtained from brain banks, Costa and his colleagues found that the level of reelin was half that in normal human brains.

To confirm that finding, the UIC scientists conducted a blind study of 60 brains taken postmortem from individuals diagnosed with schizophrenia, unipolar depression or bipolar disorder with psychosis, and individuals with no psychiatric abnormalities. They correctly identified those that came from psychotic patients by testing for levels of reelin. Controls in the experiment ruled out the possibility that the decrease in reelin was due to drugs the individuals had taken to treat their psychoses or to other possible effects.

Costa is now investigating the mechanism by which reelin acts, in collaboration with UIC neuroscientists Hector Caruncho, Dennis Grayson, Alessandro Guidotti, George Pappas, Christine Pezold, Neil Smalheiser and Doncho Uzunov. In a paper to be published in the Proceedings of the National Academy of Science, Costa and his colleagues report finding reelin associated with the dendritic spines of neurons in the cortex. These dendritic spines -- branching fingerlike extensions of the neurons that receive inputs from a complex of other neurons -- are thought to be involved in learning. The UIC scientists suggest that reelin may act by interfering wi

Contact: Sharon Butler
University of Illinois at Chicago

Page: 1 2 3

Related medicine news :

1. Promising new strategy for Swedish medical research
2. Promising treatments for Huntingtons disease identified in UCI study
3. Promising results for malaria vaccine trial
4. Promising diagnostic test for sleeping sickness
5. Promising new treatment options for people with co-existing alcohol-use and psychiatric disorders
6. Promising drug fails to thwart fatal lung disease in large trial
7. Promising drug proves ineffective as treatment for hearing loss
8. Promising West Nile virus vaccine protects monkeys
9. Promising new treatment preserves bone mass in mice; May help women and men with osteoporosis
10. Promising vaccine may provide long-lasting protection against malaria
11. UI Study Suggests Promising Treatment For Diabetic Pregnancies

Post Your Comments:

(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations ... literacy software tool, and the Cancer Patient Education Network (CPEN), an independent professional ... announce a new strategic alliance. , As CPEN’s strategic partner, HLI will ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance in ... medical-grade battery-powered display stand specifically designed for endoscopy environments. An innovative ... into a clinical solution to support the improvement of patient outcomes, ... Design ... Solution ...
(Date:10/4/2017)... Mass. , Oct. 4, 2017  According to the Centers for ... the end of October . PhysicianOne Urgent Care is helping communities across ... Westchester, NY , by offering no-cost* flu shots through the ... as mandated by certain health insurance regulations. ... The best time to get a flu shot is by the ...
(Date:10/2/2017)... 2, 2017 Halo Labs announces the European launch of ... the HORIZON at MIBio 2017 in Cambridge, U.K ... particulate matter in biopharmaceutical samples with unprecedented speed and sensitivity while ... technique Backgrounded Membrane Imaging. ... HORIZON subvisible particle analysis system ...
Breaking Medicine Technology:
Cached News: