HOME >> MEDICINE >> NEWS
Promising new treatment preserves bone mass in mice; May help women and men with osteoporosis

A completely new type of therapy, using a unique class of synthetic compounds, may someday protect both men and women from the bone-weakening disease osteoporosis. Researchers reported in the October 25 issue of Science that early studies of one of these compounds called estren successfully preserved and even restored bone mass in an animal model without the side effects associated with sex hormone therapies.

The group found that estren protected bone mass in both female and male mice as well as estrogen or testosterone did, but without the changes in reproductive organs associated with sex hormone therapy. They call this new class of compounds, ANGELS (Activators of Non-Genomic Estrogen-Like Signalling).

"The sex hormones estrogen and testosterone play a role in building bone throughout life as well as protecting the reproductive health of both sexes. To safeguard the bone mass often lost as women age, doctors may give estrogen. This is quite effective at preserving bone, but can have serious side effects," explained Jill Carrington, Ph.D., from the Biology of Aging Program at the National Institute on Aging (NIA). "This study suggests a new direction in research toward treating the disabling disease osteoporosis in both men and women." The NIA and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) supported the study by Stavros Manolagas, M.D., Ph.D., and colleagues at the University of Arkansas for Medical Sciences (UAMS) and the Central Arkansas Veterans Health Care System (CAVHCS), Little Rock, AR.

This new therapy evolved out of our knowledge of the role that sex hormones play in bone remodeling. Based on earlier work by Dr. Manolagas, he and his associates hypothesized that thebone building actions of sex hormones could be separated from their effects on the reproductive system; a different process seemed to be involved. If so, they proposed that it should be possible to trigger the bone building activit
'"/>

Contact: Karin Kolsky
kolskyk@nia.nih.gov
301-496-1752
NIH/National Institute on Aging
24-Oct-2002


Page: 1 2 3

Related medicine news :

1. Promising new strategy for Swedish medical research
2. Promising treatments for Huntingtons disease identified in UCI study
3. Promising results for malaria vaccine trial
4. Promising diagnostic test for sleeping sickness
5. Promising new treatment options for people with co-existing alcohol-use and psychiatric disorders
6. Promising drug fails to thwart fatal lung disease in large trial
7. Promising drug proves ineffective as treatment for hearing loss
8. Promising West Nile virus vaccine protects monkeys
9. Promising vaccine may provide long-lasting protection against malaria
10. Promising new research on schizophrenia causes
11. UI Study Suggests Promising Treatment For Diabetic Pregnancies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... Calif. (PRWEB) , ... September 01, 2020 , ... ... a new practice in Glendale. While the office will be the ... as breast augmentation, tummy tucks, buttock augmentation (Brazilian butt lift), as well as ...
(Date:8/31/2020)... ... August 31, 2020 , ... Cardiothoracic ... joining biomedical engineers from Carnegie Mellon University (CMU) to develop a new heart ... have undergone open heart surgery. , The AGH/CMU team was recently awarded a ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... cloud-based business management solution for chiropractors, announced today the launch of its integrated, ... professionals can start running their virtual practice in under 90 seconds. , ...
(Date:8/31/2020)... CHICAGO (PRWEB) , ... August 31, 2020 , ... In ... Chicago West Loop is donating 10 percent of each hotel room booked with ... House Charities® of Chicagoland & Northwest Indiana (RMHC-CNI) , effective immediately. Donations will ...
(Date:8/28/2020)... ... 28, 2020 , ... WHAT , Hespiro™ is a new ... conditions, including COVID-19, while reducing the need for scarce mechanical ventilators. It not ... and scrubs it free of carbon dioxide in a completely closed “rebreather” system, ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... ... 26, 2020 , ... Unscrupulous sellers across the country are ... purification technologies, including GreenTech Environmental’s proprietary methods, have been used successfully to curb ... has published results of singular and scientific testing against the coronavirus. , As ...
(Date:8/26/2020)... ... ... As the U.S. struggles in its 6th month of fighting Covid-19, Americans ... mask, keep your distance, wash your hands. Prevention is the best tool for now. ... “How much better it is to prevent disease than to cure it.” , Part ...
(Date:8/26/2020)... ... ... Hero Life Sciences announced today that it will be setting up ... masks and N95 respirators in its manufacturing plant located in the City of Corona, ... facing in trying to find quality disposable face masks during the COVID-19 pandemic and ...
Breaking Medicine Technology:
Cached News: