Promising new treatment preserves bone mass in mice; May help women and men with osteoporosis

A completely new type of therapy, using a unique class of synthetic compounds, may someday protect both men and women from the bone-weakening disease osteoporosis. Researchers reported in the October 25 issue of Science that early studies of one of these compounds called estren successfully preserved and even restored bone mass in an animal model without the side effects associated with sex hormone therapies.

The group found that estren protected bone mass in both female and male mice as well as estrogen or testosterone did, but without the changes in reproductive organs associated with sex hormone therapy. They call this new class of compounds, ANGELS (Activators of Non-Genomic Estrogen-Like Signalling).

"The sex hormones estrogen and testosterone play a role in building bone throughout life as well as protecting the reproductive health of both sexes. To safeguard the bone mass often lost as women age, doctors may give estrogen. This is quite effective at preserving bone, but can have serious side effects," explained Jill Carrington, Ph.D., from the Biology of Aging Program at the National Institute on Aging (NIA). "This study suggests a new direction in research toward treating the disabling disease osteoporosis in both men and women." The NIA and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) supported the study by Stavros Manolagas, M.D., Ph.D., and colleagues at the University of Arkansas for Medical Sciences (UAMS) and the Central Arkansas Veterans Health Care System (CAVHCS), Little Rock, AR.

This new therapy evolved out of our knowledge of the role that sex hormones play in bone remodeling. Based on earlier work by Dr. Manolagas, he and his associates hypothesized that thebone building actions of sex hormones could be separated from their effects on the reproductive system; a different process seemed to be involved. If so, they proposed that it should be possible to trigger the bone building activit

Contact: Karin Kolsky
NIH/National Institute on Aging

Page: 1 2 3

Related medicine news :

1. Promising new strategy for Swedish medical research
2. Promising treatments for Huntingtons disease identified in UCI study
3. Promising results for malaria vaccine trial
4. Promising diagnostic test for sleeping sickness
5. Promising new treatment options for people with co-existing alcohol-use and psychiatric disorders
6. Promising drug fails to thwart fatal lung disease in large trial
7. Promising drug proves ineffective as treatment for hearing loss
8. Promising West Nile virus vaccine protects monkeys
9. Promising vaccine may provide long-lasting protection against malaria
10. Promising new research on schizophrenia causes
11. UI Study Suggests Promising Treatment For Diabetic Pregnancies

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a ... has been awarded a contract by the Center for Medicare and Medicaid Services ... accelerate the enterprise use of Agile methodologies in a consistent and high value ...
(Date:10/13/2017)... ... , ... “America On The Brink”: the Christian history of the United States ... creation of published author, William Nowers. Captain Nowers and his wife, Millie, have ... thirty years in the Navy. Following his career as a naval aviator and ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has ... today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula ... the highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, ...
(Date:10/12/2017)... ... 12, 2017 , ... The American College of Medical Informatics (ACMI) will present ... the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... Collen, a pioneer in the field of medical informatics, this prestigious award is presented ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... IRVING, Texas , Oct. 6, 2017   ... industry with more than $100 billion in purchasing power, ... industry news and information. The Newsroom is ... chain and industry trends, infographics, expert bios, news releases, ... Besides having access to a wealth of resources at ...
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
(Date:10/2/2017)... -- Halo Labs announces the European launch of their new low ... MIBio 2017 in Cambridge, U.K on October ... biopharmaceutical samples with unprecedented speed and sensitivity while using far less ... Imaging. ... analysis system ...
Breaking Medicine Technology:
Cached News: