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Proposed addiction treatment successful, safe in second small trial

the past year, it is remarkable that 16 of 30 avoided using these highly addictive drugs for approximately four consecutive weeks while on GVG," Dewey said.

"Of course, the conclusive demonstration of treatment efficacy can only be provided by an appropriately blinded randomized study, where some patients are given GVG and others a placebo, and neither the researchers nor the subjects know which is which until after the results are analyzed," said Brodie.

With the lack of visual side effects observed for the doses used in this study -- a factor that has been viewed as an impediment to getting GVG approved in the U.S. -- the scientists hope to see such a large-scale study conducted soon.

"We are unaware of any pharmacologic strategy that has been useful in treating methamphetamine dependence, making these findings with GVG unique both in terms of safety and efficacy," Brodie said.


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Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
15-Nov-2004


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