Prostate cancer program at UCLAs Jonsson Cancer Center designated a site of research ...( therapies that inhibit the growth of pr...),Health

therapies that inhibit the growth of prostate cancer. Their laboratory studies currently are evaluating the effectiveness of drugs that target and turn off a key growth-signaling pathway called the epidermal growth factor receptor (EGFR). The EGFR is a part of the HER kinase family of proteins that regulate cell growth and can stimulate the spread of tumors when over-expressed on cancer cells. Ultimately, these studies will lead to an understanding of the molecular mechanisms involved in the growth and treatment of prostate cancer. Other studies in the laboratory and in clinical trials will examine the effectiveness of using a monoclonal antibody to target a protein called HER-2/neu that controls cell growth. Drs. Aronson, Cohen, John Glaspy and nutritionist and researcher Dilprit Bagga will investigate whether a low-fat diet with fish-oil supplements can be used to prevent and/or treat prostate cancer. Researchers believe the type of dietary fat is likely to be important in prostate cancer development, and their strategy calls for a decrease in omega-6 fatty acids found in animal and vegetable fats and an increase in omega-3 fatty acids delivered through dietary fish and fish-oil supplements. Laboratory studies at UCLA have shown that a low-fat diet and omega-3 fatty acids inhibit the growth of prostate cancer cells in test tubes and in animal models. Human studies will focus on men with prostate cancer and will determine if and how this diet works to prevent or treat the disease.

There are a lot of reasons to think that the risk for prostate cancer can be lowered through diet, said Glaspy, who also has studied a low-fat diet with fish-oil supplements in women with breast cancer. Men in Japan, where they eat more omega-3 fatty acids, have a much lower incidence of prostate cancer than men in American, where we consume more omega-6 fatty acids. That cant be a coincidence.

Sawyers, who has been investigating prostate cancer for nearly a de
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Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
22-Oct-2002

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