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Prostate cancer screening practices examined

arallel many medical recommendations and reassure us that good judgment is being applied to the evaluation of the initial screen," Andriole says. "We are confident that when the study is ultimately completed, it will truly measure the effect of current medical practices."

In men with suspicious PSA readings, regardless of DRE findings, biopsy revealed cancer almost half the time, while in men with suspicious DRE tests, regardless of PSA levels, biopsy found cancer about a third of the time.

The majority of men with cancer had localized cancers. About ten percent had more serious advanced forms. These advanced cancers were linked to higher PSA numbers and suspicious DRE results.

Overall, 1.4 percent of the approximately 34,000 men screened were subsequently diagnosed with prostate cancer by tissue biopsy. This rate of detection is lower than in two previous studies of prostate cancer screening, which found cancer in 4.2 and 3.2 percent of patients, respectively.

This lower rate of detection more accurately reflects the contemporary standards of practice, because biopsy and diagnosis took place outside of the PLCO study, according to the authors.


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Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
15-Mar-2005


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