HOME >> MEDICINE >> NEWS
Protein helps immune system mount 'instant strike' against deadly flu viruses

Researchers at the University of Rochester have identified a protein in the immune system that appears to play a crucial role in protecting against deadly forms of influenza, and may be particularly important in protecting against emerging flu viruses like the avian flu. The researchers believe that a vaccine made with a live but weakened strain of flu virus such as the inhaled flu vaccine introduced last year may activate this part of the immune system and offer the best defense against avian flu.

In a paper being published in the February 20 issue of Immunity, the researchers report that a protein called VLA-1 enables the immune system to develop "peripheral immunity" by anchoring millions of virus-killing cells to tissues along the airways and lungs, where flu enters the body. The protein holds the cells in place and helps them survive there for long periods sometimes years where they stand ready to mount an immediate attack on the flu virus.

In a series of experiments, mice whose T cells were able to make the protein were able to develop peripheral immunity, and 90 percent of them survived after being infected with a potentially deadly strain of flu. Mice with T-cells engineered to lack the protein failed to develop peripheral immunity, and only 60 percent of them survived after being infected with the same flu virus.

The findings demonstrate that when confronted by a potentially deadly flu strain, an effective first strike by T cells in the lungs can mean the difference between life and death. To immunologist David Topham, Ph.D., assistant professor of Microbiology and Immunology at the University of Rochester and lead author of the study, the findings reveal something else: a shortcoming in the world's most widely administered flu vaccines. Those vaccines, made with fragments of "killed" viruses, help the immune system make antibodies against the flu virus but do not induce peripheral immunity.

The trouble with anti
'"/>

Contact: Chris DiFrancesco
chris_difrancesco@urmc.rochester.edu
585 273-4790
University of Rochester Medical Center
19-Feb-2004


Page: 1 2

Related medicine news :

1. Protein that helps skin cancer spread identified by Stanford researchers
2. Proteins found in urine of pregnant women could help diagnose preeclampsia
3. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
4. Protein key could aid search for cancer drugs
5. Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
6. Protein not only aids nerve development, but promotes blood vessel growth, too
7. Protein marker predicts possible heart damage after chemotherapy
8. Protein promotes cancer metastasis and survival
9. Protein that predicts tamoxifen resistance is identified
10. Protein identified that may play central role in inflammatory bowel disease
11. Protein implicated in decline of aging hearts

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2020)... ... 2020 , ... Representatives with Bay-Bay Water today announced that the company has launched ... company logo as part of the ongoing evolution of our company’s brand,” said Osmay Gonzalez, ... company is expanding its national reach. , “We have refreshed our logo to reflect who ...
(Date:2/20/2020)... ... , ... R3 Medical Training announced its next joint injection training courses scheduled ... injections for all large and small joints along with ultrasound needle guidance. , Performing ... opportunity is to perform injections in a supervised setting. R3 Medical Training's joint ...
(Date:2/19/2020)... MONROE, Conn. (PRWEB) , ... February 19, 2020 ... ... respected periodontists at Advanced Periodontics and Dental Implant Center of Connecticut, celebrate 30 ... all new patients with the same low fees that they charged in 1989, ...
(Date:2/19/2020)... (PRWEB) , ... February 19, 2020 , ... ... quality and consistency of healthcare delivery, announced that it will participate in the ... in Orlando, Florida. BPM+ Health will engage healthcare professionals and other stakeholders at ...
(Date:2/16/2020)... ... 2020 , ... Canadian digital healthcare portal Ask The Doctor has ... about the Coronavirus. , "It is our duty and it is our responsibility to ... said Prakash Chand, CEO of Ask The Doctor. , Doctors and nurses around the ...
Breaking Medicine News(10 mins):
(Date:2/20/2020)... ... 2020 , ... NeoTract, a wholly owned subsidiary of Teleflex ... announced that Jayant Uberoi, MD, Chesapeake Urology in Baltimore MD, has been designated ... achieved a high level of training and experience with the UroLift® System and ...
(Date:2/19/2020)... ... February 19, 2020 , ... Aspire Regenerative, a leader ... with Cortex Wellness Pharmacy for a free weight-loss event on March 1, 2020. It ... Ave., #100, La Jolla, CA, 92037. , During the event, physicians and pharmacists will ...
(Date:2/19/2020)... ... February 19, 2020 , ... The Team Type 1 Foundation, ... medicine for everyone affected by diabetes, announced a partnership with VeloCity, a fundraising ride ... third annual VeloCity event takes place on May 2nd and begins on the Mercedes-Benz ...
Breaking Medicine Technology:
Cached News: