HOME >> MEDICINE >> NEWS
Protein identified that may play central role in inflammatory bowel disease

CHARLOTTESVILLE, Va., Nov. 10 Researchers at the University of Virginia Health System have discovered that a protein expressed by the immune system, called TL1A, is linked to inflammatory bowel disease (IBD) in patients, especially Crohn's disease. This is the first time TL1A has been linked to Crohn's. In a study involving fifty patients at U.Va., published in the Nov. 1 issue of The Journal of Immunology, the research team found that TL1A was expressed in patients suffering from IBD, but not in control patients who are disease free. The finding could lead to new treatments for people who suffer from IBD, the general name for two diseases that cause inflammation in the intestines.

Ulcerative colitis causes inflammation and ulcers in the top layer of the intestinal lining, usually in the lower part of the large intestine, while in Crohn's, the inflammation extends deep into the lining, usually in the small intestine. Over one million adults and children in the U.S. suffer from inflammatory bowel disease, with about 30,000 new cases diagnosed each year, according to the Crohn's and Colitis Foundation of America. Adolescents and young adults are most susceptible to IBD and there is no cure.

"What we have discovered here at U.Va. is a cytokine, a key protein that regulates the immune response, that could be an important target for therapy in IBD patients who are not responding to current treatments for ulcerative colitis and Crohn's disease," said Dr. Fabio Cominelli, principal investigator of the study, professor of internal medicine and microbiology and director of the Digestive Health Center of Excellence at U.Va. "Blocking the interaction between TL1A and its receptor in the immune response, called DR3, could be beneficial to the thousands of people suffering from chronic intestinal inflammation."

TL1A is a newly discovered member of the tumor necrosis factor (TNF) family of proteins thought to be expressed primarily in the e
'"/>

Contact: Bob Beard
reb8e@virginia.edu
434-982-4490
University of Virginia Health System
10-Nov-2003


Page: 1 2

Related medicine news :

1. Protein that helps skin cancer spread identified by Stanford researchers
2. Proteins found in urine of pregnant women could help diagnose preeclampsia
3. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
4. Protein key could aid search for cancer drugs
5. Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
6. Protein not only aids nerve development, but promotes blood vessel growth, too
7. Protein marker predicts possible heart damage after chemotherapy
8. Protein promotes cancer metastasis and survival
9. Protein helps immune system mount instant strike against deadly flu viruses
10. Protein that predicts tamoxifen resistance is identified
11. Protein implicated in decline of aging hearts

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2016)... ... 30, 2016 , ... Powerful tools of hypnosis, hypnotherapy ... What is hypnosis and hypnotherapy and why after centuries, it is now ... (chronic and acute), birthing processes and medical procedures, depression, anxiety, fear reactions, anxiety ...
(Date:4/30/2016)... ... April 30, 2016 , ... ... and CEO of EMED, today signed a multifaceted agreement which will allow for ... Northern Caribbean University Department of Natural and Applied Sciences, Allied Health and Nursing ...
(Date:4/30/2016)... Indianapolis, Indiana (PRWEB) , ... April 30, 2016 , ... ... USA Wrestling as they go for gold in Rio. Under the care of ... including two golds! , In an unprecedented showing, Maximized Living is sending the largest ...
(Date:4/29/2016)... ... ... In an article published April 16th on the New York ... injections, which she underwent in order to feel more at home at this year’s ... article explains that Ms. Mirmelli’s situation is not unique; many plastic surgeons say they’ve ...
(Date:4/29/2016)... ... 29, 2016 , ... Shamangelic Healing, Sedona Arizona's Premier ... Alpha BRAIN and New Mood Daily-Stress Formula for brain optimization and wellness to ... the store is just one more way Shamangelic Healing supports people’s quest for ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 2016 Shire plc (LSE: SHP, NASDAQ: ... Chief Financial Officer, will present at the Deutsche Bank 41st ... on Wednesday, May 04, 2016, 10:00 am EDT (15:00 ... on the Presentations and Webcasts section of Shire,s Investor website ... will be available on this same website for approximately 90 ...
(Date:4/27/2016)... FRANCISCO , April 27, 2016 ... reach over USD 2.14 billion by 2022, according ... Inc.       (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ... technological advancement affecting the efficiency and accuracy delivered ... the persistent demand for novel urinalysis instruments and ...
(Date:4/26/2016)... Diplomat Pharmacy, Inc. (NYSE: DPLO) is pleased ... Pharm D., to Vice President of Education and Quality. ... will continue to lead and oversee Diplomat University, an ... and training to Diplomat employees and external professionals on ... also houses the quality assurance department, which focuses on ...
Breaking Medicine Technology:
Cached News: