HOME >> MEDICINE >> NEWS
Protein identified that may play central role in inflammatory bowel disease

CHARLOTTESVILLE, Va., Nov. 10 Researchers at the University of Virginia Health System have discovered that a protein expressed by the immune system, called TL1A, is linked to inflammatory bowel disease (IBD) in patients, especially Crohn's disease. This is the first time TL1A has been linked to Crohn's. In a study involving fifty patients at U.Va., published in the Nov. 1 issue of The Journal of Immunology, the research team found that TL1A was expressed in patients suffering from IBD, but not in control patients who are disease free. The finding could lead to new treatments for people who suffer from IBD, the general name for two diseases that cause inflammation in the intestines.

Ulcerative colitis causes inflammation and ulcers in the top layer of the intestinal lining, usually in the lower part of the large intestine, while in Crohn's, the inflammation extends deep into the lining, usually in the small intestine. Over one million adults and children in the U.S. suffer from inflammatory bowel disease, with about 30,000 new cases diagnosed each year, according to the Crohn's and Colitis Foundation of America. Adolescents and young adults are most susceptible to IBD and there is no cure.

"What we have discovered here at U.Va. is a cytokine, a key protein that regulates the immune response, that could be an important target for therapy in IBD patients who are not responding to current treatments for ulcerative colitis and Crohn's disease," said Dr. Fabio Cominelli, principal investigator of the study, professor of internal medicine and microbiology and director of the Digestive Health Center of Excellence at U.Va. "Blocking the interaction between TL1A and its receptor in the immune response, called DR3, could be beneficial to the thousands of people suffering from chronic intestinal inflammation."

TL1A is a newly discovered member of the tumor necrosis factor (TNF) family of proteins thought to be expressed primarily in the e
'"/>

Contact: Bob Beard
reb8e@virginia.edu
434-982-4490
University of Virginia Health System
10-Nov-2003


Page: 1 2

Related medicine news :

1. Protein that helps skin cancer spread identified by Stanford researchers
2. Proteins found in urine of pregnant women could help diagnose preeclampsia
3. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
4. Protein key could aid search for cancer drugs
5. Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
6. Protein not only aids nerve development, but promotes blood vessel growth, too
7. Protein marker predicts possible heart damage after chemotherapy
8. Protein promotes cancer metastasis and survival
9. Protein helps immune system mount instant strike against deadly flu viruses
10. Protein that predicts tamoxifen resistance is identified
11. Protein implicated in decline of aging hearts

Post Your Comments:
(Date:7/23/2014)... Steven Reinberg HealthDay ... -- Many obese and overweight American children and teens ... is fine, U.S. health officials reported Wednesday. "Being ... such as high blood pressure, high cholesterol and diabetes," ... the U.S. Centers for Disease Control and Prevention,s National ...
(Date:7/23/2014)... 2014 Home Care Assistance Calgary ... seniors, is proud to announce the next installment in ... a wide range of health and wellness-related fields. The ... award-winning author Nancy Kriseman, and will cover the most ... burnout by becoming more self-aware. In particular, Nancy will ...
(Date:7/23/2014)... new study supports a growing body of research ... steroid hormones in treating postmenopausal breast cancer, with ... than with standard anti-hormone therapies. The study will ... open-access journal Reproductive Biology and Endocrinology . ... cancer in women in the United States. Approximately ...
(Date:7/23/2014)... DC (PRWEB) July 23, 2014 ... for ATA 2015, ATA’s twentieth annual meeting and ... The meeting, expected to attract over 5,000 attendees ... will take place May 3-5, 2015, in Los ... most renowned healthcare technology professionals from researchers, clinicians, ...
(Date:7/23/2014)... X syndrome ( FXS ) is a genetic disorder ... on the autistic spectrum, as well as cognitive deficits. ... impairment and the most common cause of autism. , ... have published a study that sheds light ... online today (July 23) in the Journal of ...
Breaking Medicine News(10 mins):Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 2Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 3Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 2Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5Health News:ATA Seeks Speakers to Present at the World’s Largest Telemedicine, mHealth and Telehealth Conference 2Health News:Study links enzyme to autistic behaviors 2Health News:Study links enzyme to autistic behaviors 3
(Date:7/23/2014)... 23, 2014 Pharmavite LLC announced that Timothy ... officer effective immediately. Toll recently served as Pharmavite,s executive ... category management, private label and sales administration in ... global role, Toll will expand his responsibilities to include ... "Toll,s appointment to chief customer officer is part ...
(Date:7/23/2014)... 23, 2014 Research and Markets ... "Global Electrophysiology Ablation Catheters Market 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 Catheter ablation is a ... faulty electrical pathways from sections of the heart ... cardiac arrhythmias). Cardiac arrhythmias can be of several ...
(Date:7/23/2014)... , July 23, 2014 PositiveID ... Fla. , is an emerging player in ... systems for bio-threat detection and rapid medical testing. ... M-BAND (Microfluidic Bio-agent Autonomous Networked Detector), was developed ... Security ("DHS") Science & Technology directorate, and $30 ...
Breaking Medicine Technology:Global Electrophysiology Ablation Catheters Market 2014-2018: Key Vendors are Boston Scientific, Johnson & Johnson, Medtronic and St. Jude Medical 2Global Electrophysiology Ablation Catheters Market 2014-2018: Key Vendors are Boston Scientific, Johnson & Johnson, Medtronic and St. Jude Medical 3PositiveID Analyst Inspection: Emerging Contender in BioThreat Detection - First Ever Revenue Guidance and Backlog Position Company for Increased Visibility and Traction - by SmallCapTraders.com 2
Cached News: