HOME >> MEDICINE >> NEWS
Protein marker predicts possible heart damage after chemotherapy

DALLAS, May 18 High levels of troponin I (TNI) protein in the blood helps identify possible heart damage after cancer treatment, according to a report in today's rapid access issue of Circulation: Journal of the American Heart Association.

The report also suggests that tracking TNI levels can help doctors form a heart disease prevention plan for some chemotherapy patients. "Damage to the heart is one of the most worrisome long-term side effects of high-dose chemotherapy," said lead author Daniela Cardinale, M.D., deputy director of the cardiology unit at the European Institute of Oncology in Milan, Italy. "Therefore, it is important to identify biochemical markers that might indicate which patients are at greatest risk and how severe their heart disease might be."

TNI is a protein present exclusively in heart cells. The TNI blood concentration is a well-established marker of heart muscle injury that's widely used to diagnose and treat heart attacks and other acute coronary syndromes.

"Our study is the first to clearly show, in an adult population, that the risk of cardiac events in cancer patients can be predicted by evaluating the TNI release pattern after chemotherapy," Cardinale said.

In cancer patients who have had chemotherapy, physicians usually use extensive testing and expensive monitoring equipment to identify which patients may have cardiac toxicity, Cardinale said. These methods "have low sensitivity, poor predictive value and, in some cases, technical limitations. Moreover, these methods identify cardiac damage only when it has already occurred and, in most cases, is not reversible," she said. "Evaluating TNI value after chemotherapy is an easy, non-invasive, low-cost method that allows us to categorize the risk of cardiac events in cancer patients in the three years following chemotherapy."

Researchers took blood samples of 703 cancer patients to measure TNI soon after high-dose chemotherapy and one month later.
'"/>

Contact: Carole Bullock
carole.bullock@heart.org
214-706-1279
American Heart Association
17-May-2004


Page: 1 2

Related medicine news :

1. Protein that helps skin cancer spread identified by Stanford researchers
2. Proteins found in urine of pregnant women could help diagnose preeclampsia
3. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
4. Protein key could aid search for cancer drugs
5. Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
6. Protein not only aids nerve development, but promotes blood vessel growth, too
7. Protein promotes cancer metastasis and survival
8. Protein helps immune system mount instant strike against deadly flu viruses
9. Protein that predicts tamoxifen resistance is identified
10. Protein identified that may play central role in inflammatory bowel disease
11. Protein implicated in decline of aging hearts

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... AUSTIN, Texas (PRWEB) , ... August 04, 2020 ... ... and older adults living with memory impairment, has announced the Best Memory Care ... location, access to experts, facility features and amenities. , According to the ...
(Date:8/3/2020)... Texas (PRWEB) , ... August 03, 2020 , ... ... today announced enrollment of the first patients with first-line advanced pancreatic cancer in ... phase 1/2 1801 trial of 9-ING-41, (NCT03678883, EudraCT#:2018-003739-32). 9-ING-41 is Actuate’s proprietary ...
(Date:7/22/2020)... ... 22, 2020 , ... Whatever we call them – sunspots, age spots, liver ... glow,” notes Angie Seelal, a Certified Registered Physician Assistant specializing in Dermatology with ... later and make us look older.” , In terms of the name, ‘sunspots’ or ...
(Date:7/22/2020)... (PRWEB) , ... July 22, 2020 , ... ... announced the launch of its new Data Curation as a Service (DCaaS) solution ... case modules focus on specific clinical data curation parameters and are custom tailored ...
(Date:7/18/2020)... ... 17, 2020 , ... Nader Sanai, M.D., director of the Ivy Brain Tumor ... second annual Glioblastoma Awareness Day (#GBMDay) on July 22, 2020 to raise national consciousness. ... glioblastoma , the most common and aggressive form of brain cancer. It also ...
Breaking Medicine News(10 mins):
(Date:8/3/2020)... ... August 03, 2020 , ... PMI Advisors, a ... services for small business owners. These plans help ensure that companies actually ... their teams for 30-90 days as a result of sickness or injury. , ...
(Date:8/3/2020)... ... August 03, 2020 , ... LaVoieHealthScience (LHS), an integrated investor ... that Donna L. LaVoie, President, CEO and Founder of LHS, has been named to ... Since 2005, the PharmaVOICE 100 has honored more than 1,500 industry executives for their ...
(Date:7/31/2020)... ... July 31, 2020 , ... ... for reprocessing the St. Jude Medical BRK Transseptal Needle and the Baylis Medical ... a milestone in single-use device reprocessing, as no other company is able to ...
Breaking Medicine Technology:
Cached News: