HOME >> MEDICINE >> NEWS
Protein that helps skin cancer spread identified by Stanford researchers

STANFORD, Calif. - A protein that normally helps hold the skin intact is also needed by skin cancer cells as they spread to other regions of the body, researchers at the Stanford University School of Medicine have discovered. Identifying this protein's role opens the door for stopping the spread of this deadly cancer-the second most common cancer type in the United States.

The work, which appears in the March 18 issue of Science, is the first published research implicating the protein, collagen VII, in cancer.

The finding came about because roughly two-thirds of children with a blistering skin disorder called recessive dystrophic epidermolysis bullosa, or RDEB - caused by a mutation that leads to an altered or missing collagen VII protein - develop a type of skin cancer called squamous cell carcinoma. This led Paul Khavari, MD, PhD, the Carl J. Herzog Professor in Dermatology, to suspect that the protein had something to do with cancer formation.

What Khavari and postdoctoral scholar Susana Ortiz-Urda, MD, PhD, found is that a fragment of collagen VII is required for the skin cancer cells to break free from the neighboring skin tissue and spread - a step that turns an otherwise benign tumor into a killer. "When we blocked this sequence we also blocked the cancer from spreading," said Khavari, who is also chief of dermatology at the Veterans Affairs Palo Alto Health Care System.

The group found this sequence by studying skin samples from 12 children with RDEB. They used laboratory tools to activate molecular switches that normally turn skin cells cancerous. What they found was surprising. Four of the 12 samples never turned cancerous, no matter what cancer-promoting molecular switches the researchers had flicked. The remaining eight samples became cancerous much like normal skin cells that the researchers had studied previously.

It turns out that the difference in cancer formation had to do with the type of alterati
'"/>

Contact: Amy Adams
amyadams@stanford.edu
650-723-3900
Stanford University Medical Center
17-Mar-2005


Page: 1 2 3

Related medicine news :

1. Proteins found in urine of pregnant women could help diagnose preeclampsia
2. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
3. Protein key could aid search for cancer drugs
4. Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
5. Protein not only aids nerve development, but promotes blood vessel growth, too
6. Protein marker predicts possible heart damage after chemotherapy
7. Protein promotes cancer metastasis and survival
8. Protein helps immune system mount instant strike against deadly flu viruses
9. Protein that predicts tamoxifen resistance is identified
10. Protein identified that may play central role in inflammatory bowel disease
11. Protein implicated in decline of aging hearts

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... The American Medical Spa ... April 7, to Saturday, April 10, 2021, at Wynn Las Vegas. The event ... national trade show for non-invasive medical aesthetic practices that brings together owners, physicians, ...
(Date:9/1/2020)... , ... September 01, 2020 , ... ... new practice in Glendale. While the office will be the first to ... augmentation, tummy tucks, buttock augmentation (Brazilian butt lift), as well as rhinoplasty, facial ...
(Date:9/1/2020)... ... September 01, 2020 , ... Dr. Kiran Gill ... aesthetic surgery of the face, breast, and body. In 2018, she founded Aesthetics ... plastic surgery and aesthetic practice in Southwest Florida. Dr. Gill and her team ...
(Date:8/31/2020)... ... August 31, 2020 , ... Ocean ... face masks to medical first responders across the United States. Since the start ... personal protective equipment (PPE) medical centers , hospitals , firefighters ...
(Date:8/31/2020)... ... 31, 2020 , ... Smile Brands Inc., one of the ... States, today announced the grand opening of another affiliated Bright Now! Dental ... convenient hours, a comfortable office, and full-service care at the new Beaumont location. ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... ... 2020 , ... ScripHessco has announced the release of their ... ways that chiropractors can help heal sports injuries and get athletes on the ... unusual amount of pressure and stress on their bodies, so checkups to maintain ...
(Date:8/26/2020)... , ... August 26, 2020 ... ... company today announced that it has entered into definitive agreement to acquire ... primarily focused on pharmacists and pharmacy technicians. , CEA represents a ...
(Date:8/26/2020)... ... August 26, 2020 , ... ... to funding innovative lymphoma research and serving the lymphoma community through education programs, ... special virtual LRF Gala and Charity Auction on Wednesday, Sept. 30 . ...
Breaking Medicine Technology:
Cached News: