HOME >> MEDICINE >> NEWS
Protein that helps skin cancer spread identified by Stanford researchers

STANFORD, Calif. - A protein that normally helps hold the skin intact is also needed by skin cancer cells as they spread to other regions of the body, researchers at the Stanford University School of Medicine have discovered. Identifying this protein's role opens the door for stopping the spread of this deadly cancer-the second most common cancer type in the United States.

The work, which appears in the March 18 issue of Science, is the first published research implicating the protein, collagen VII, in cancer.

The finding came about because roughly two-thirds of children with a blistering skin disorder called recessive dystrophic epidermolysis bullosa, or RDEB - caused by a mutation that leads to an altered or missing collagen VII protein - develop a type of skin cancer called squamous cell carcinoma. This led Paul Khavari, MD, PhD, the Carl J. Herzog Professor in Dermatology, to suspect that the protein had something to do with cancer formation.

What Khavari and postdoctoral scholar Susana Ortiz-Urda, MD, PhD, found is that a fragment of collagen VII is required for the skin cancer cells to break free from the neighboring skin tissue and spread - a step that turns an otherwise benign tumor into a killer. "When we blocked this sequence we also blocked the cancer from spreading," said Khavari, who is also chief of dermatology at the Veterans Affairs Palo Alto Health Care System.

The group found this sequence by studying skin samples from 12 children with RDEB. They used laboratory tools to activate molecular switches that normally turn skin cells cancerous. What they found was surprising. Four of the 12 samples never turned cancerous, no matter what cancer-promoting molecular switches the researchers had flicked. The remaining eight samples became cancerous much like normal skin cells that the researchers had studied previously.

It turns out that the difference in cancer formation had to do with the type of alterati
'"/>

Contact: Amy Adams
amyadams@stanford.edu
650-723-3900
Stanford University Medical Center
17-Mar-2005


Page: 1 2 3

Related medicine news :

1. Proteins found in urine of pregnant women could help diagnose preeclampsia
2. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
3. Protein key could aid search for cancer drugs
4. Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
5. Protein not only aids nerve development, but promotes blood vessel growth, too
6. Protein marker predicts possible heart damage after chemotherapy
7. Protein promotes cancer metastasis and survival
8. Protein helps immune system mount instant strike against deadly flu viruses
9. Protein that predicts tamoxifen resistance is identified
10. Protein identified that may play central role in inflammatory bowel disease
11. Protein implicated in decline of aging hearts

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... ... flu shots to a Halloween costume parade and crafts for kids, the Steward Urgent Care ... of all ages. , The Steward Urgent Care Center in Lehi opened in July and ... the clinic will offer flu immunizations all day from 7 a.m. to 8 p.m. No ...
(Date:10/5/2018)... ... 05, 2018 , ... Newsom Eye, an ophthalmology ... Grimm specializes in comprehensive eye exams and advanced contact lens fittings including soft, ... Dr. Grimm treats patients for their pre-operative and post-operative cataract and LASIK care, ...
(Date:10/3/2018)... ... October 03, 2018 , ... The overall medical laboratory workforce ... employees in the profession are retiring, according to the results of the ... of Clinical Pathology (AJCP). , “The survey results encourage laboratory professionals to ...
(Date:10/3/2018)... , ... October 03, 2018 , ... ... Hospital Los Angeles in their mission to help children fight cancer. Co-founded by ... boxes, that launched with a purpose to raise awareness for children's healthcare. A ...
(Date:10/2/2018)... ... October 02, 2018 , ... The new website design ... This tool allows visitors to configure standard workbenches Basix™ and ... workbench to match their space with different frame colors, worksurface material options, sizes, ...
Breaking Medicine News(10 mins):
(Date:10/6/2018)... ... 06, 2018 , ... Number One On The List has ... services improve search engine ranking - clients get found and get business. Services ... Email Newsletters, SEO, Packages of Services and more. , Phoenix Physical Therapy Rehabilitation ...
(Date:10/5/2018)... ... 05, 2018 , ... Shango Las Vegas dispensary will team with Ink Ribbon ... has created pink merchandise to raise funds for the Las Vegas nonprofit group that ... a challenge for Shango. After being spurned by three national and a few local ...
(Date:10/5/2018)... ... October 05, 2018 , ... The International Association ... for its annual “Imagine Me Beyond What You See” Body Image Mannequin Art ... The competition incorporates mannequins to help create a unique and realistic palette ...
Breaking Medicine Technology:
Cached News: