HOME >> MEDICINE >> NEWS
Protein that promotes survival of stem cells might be key to poor leukemia prognosis

The complex and life-sustaining series of steps by which hematopoietic stem cells (HSC) give rise to all of the body's red and white blood cells and platelets has now been discovered to depend in large part on a single protein called Mcl-1. This finding, from an investigator at St. Jude Children's Research Hospital, is published in the February 18 issue of Science.

Mcl-1 blocks the biochemical cascade of reactions that trigger apoptosis ("cell suicide") of HSCs, according to Joseph Opferman, Ph.D., assistant member of St. Jude Biochemistry. Expression of Mcl-1 thus ensures that HSCs continue to thrive and multiply so they can complete the task of making huge numbers of blood cells. This process is extremely important during the initial development of the blood system before birth. Expression of Mc1-1 is also crucial for maintaining blood cells throughout life as red and white cells and platelets die and must be replaced. HSCs are also needed to rebuild the blood system of patients undergoing chemotherapy and radiation for cancer. Opferman completed work on this project while a member of Stanley Korsmeyer's laboratory at the Dana-Farber Cancer Institute (Boston).

Mcl-1 belongs to the Bcl-2 family of proteins. Some of these family members promote apoptosis, while others prevent it. "Other researchers have previously shown that members of the Bcl-2 family that block apoptosis are involved in regulating the number of HSCs and progenitor cells," Opferman said. "But our study showed for the first time that a single such Bcl-2 family protein--Mcl-1--is essential for promoting the survival of these cells."

Progenitor cells are precursors arising from HSCs; these cells produce daughter cells that become increasingly specialized and then produce specific types of blood cells, such as B lymphocytes--immune cells that produce antibodies.

"Understanding the role of Mcl-1 in apoptosis and how this gene is regulated will help my lab at St. Jude unde
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
23-Feb-2005


Page: 1 2 3

Related medicine news :

1. Protein that helps skin cancer spread identified by Stanford researchers
2. Proteins found in urine of pregnant women could help diagnose preeclampsia
3. Protein key could aid search for cancer drugs
4. Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
5. Protein not only aids nerve development, but promotes blood vessel growth, too
6. Protein marker predicts possible heart damage after chemotherapy
7. Protein promotes cancer metastasis and survival
8. Protein helps immune system mount instant strike against deadly flu viruses
9. Protein that predicts tamoxifen resistance is identified
10. Protein identified that may play central role in inflammatory bowel disease
11. Protein implicated in decline of aging hearts

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor ... on sciatica in a new episode of "Success Files," which is an award-winning ... innovation and investigates each subject in-depth with passion and integrity. , Sciatica occurs ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a missionary ... Journey: From the Mountains to the Mission Field” is the creation of published author, ... ages and currently teaches a class of ladies at her church, which she has ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
(Date:10/2/2017)... 2, 2017 The Rebound mobile app is poised ... reverse the tide of prescription drug addiction. The app empowers ... intake and stepping down their dosage in a safe, controlled ... December 2017; the first 100,000 people to sign up will ... http://www.rebound-solution.com/ ...
(Date:9/27/2017)... their devotion to personalized service, SMP Pharmacy Solutions announces their ... South Florida Business Journal,s 50 Fastest-Growing Companies, and listed for ... specialty pharmacy has found its niche.  To that end, the ... by SFBJ as the 2017 Power Leader in Health Care. ... award in October, Bardisa said of the three achievements, "It,s ...
Breaking Medicine Technology:
Cached News: