HOME >> MEDICINE >> NEWS
Proteins found in urine of pregnant women could help diagnose preeclampsia

Researchers at Yale School of Medicine have found that specific substances in the urine of pregnant women could serve as a screening/diagnostic tool for preeclampsia (hypertension and proteinuria during pregnancy).

The study is published in March issue of American Journal of Obstetrics and Gynecology.

"Preeclampsia is one of the most common causes of maternal mortality in the United States, but establishing a correct diagnosis can be very difficult, especially in women with hypertension prior to pregnancy," said lead author Catalin Buhimschi, M.D., assistant professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine.

Buhimschi and his colleagues developed a new algorithm to calculate the ratio for the presence or absence of three specific proteins that are normally secreted by human placenta. They examined samples of urine and blood from 132 women, some of whom had other causes of hypertension. The ratio between two of the proteins correctly identified all the women who had severe preeclampsia.

"It will take several years to develop a new diagnostic test," said Buhimschi. "Many factors are present in the serum and blood, but only the relationship between them has diagnostic significance."

The proteins studied were vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their soluble VEGF receptor (sFlt1). The ratio of sFlt1 and PlGF had a high sensitivity (88 percent) and specificity (100 percent) for identifying severe preeclampsia, and was more accurate than proteinuria alone.

Buhimschi said current tests such as liver function, proteinuria and platelet count are neither accurate nor sensitive, and results can be confusing, placing women at risk of giving birth prematurely. The current treatment is delivery of the fetus regardless of gestational age. These results provide scientists with a better understanding of the mechanisms of preeclamp
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
7-Mar-2005


Page: 1 2

Related medicine news :

1. Wistar Scientist Awarded American Cancer Society Grant For Study Of Tumor Suppressor Proteins
2. Acupuncture found to lower elevations in blood pressure
3. Potential drug target for treating cocaine abuse found
4. Similar results found in both older and younger patients undergoing weight-loss surgery
5. Infectious agent linked to mad cow disease found in organs other than the brain
6. Generation gap found in chronic pain
7. A site for sore eyes: New target for allergies found under the eyelid
8. Chemicals found in cherries may help fight diabetes
9. Thanks for the memories: cinematic portrayal of amnesia is profoundly misleading
10. Very high prevalence of virus linked to cervical cancer found in adolescent women
11. Two-fisted assault on dopamine transport system may be foundation of Parkinsons disease

Post Your Comments:
(Date:11/22/2014)... 2014 Cancer researchers in New York ... intercellular communication tunnels and the growth and spread of ... on the Surviving Mesothelioma website. , Doctors ... of Minnesota have just released their study on tunneling ... between cells. They found that mesothelioma cells ...
(Date:11/22/2014)... BambooFlooringChina.com is a famous brand in the ... new collection of bamboo mats ; the new models ... , According to the sales manager of BambooFlooringChina.com, ... a highly renewable resource. Their bamboo mats are 100% made ... comes from natural bamboo with caramel bamboo strips. ...
(Date:11/22/2014)... In order to provide better services, LunaDress has ... dresses. The business knows that a suitable cocktail party dress ... , Now, the party dresses supplier’s high quality items are ... leading company in fashion industry, LunaDress understands that it is ... So it always raises the professional level and innovation ability. ...
(Date:11/22/2014)... SATURDAY, Nov. 22, 2014 (HealthDay News) -- The wide ... can pose a threat for people with food allergies, ... there are so many types of food allergies that ... over the holidays," Dr. Guha Krishnaswamy, director of allergy ... said in a hospital news release. "If you ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 Recently, UWDress.com ... wedding guest dresses . In addition, the company ... products. , As a leading online supplier of ... of beautiful outfits. The unusual best wedding guest gowns ... Besides the amazing designs, this new selection is famous ...
Breaking Medicine News(10 mins):Health News:Study Links Cellular ‘Tunnels’ to Mesothelioma Proliferation, According to Surviving Mesothelioma 2Health News:Trendy Bamboo Mats Online Now By BambooFlooringChina.com 2Health News:LunaDress Unveils Fabulous Cocktail Party Dresses 2Health News:'Tis the Season of Challenges for Those With Food Allergies 2Health News:Best Wedding Guest dresses Introduced by UWDress.com 2
(Date:11/21/2014)... , Nov. 21, 2014 In September ... Performance Scrubs carried out a new product development plan ... very first "limited edition" lab coat , aptly ... professors of surgery in the world. The new women,s ... unisex predecessors, with a sleek envelope collar, vertical princess ...
(Date:11/21/2014)... MARCOS, Texas , Nov. 21, 2014  World ... hemp containing low THC, announces they are now offering ... comparable to Charlotte,s Web type strains grown in medical ... from other neurological disorders, such as Parkinson,s, MS, and ... for US laws to pass, because imported CBD Oil ...
(Date:11/21/2014)...  Abaxis, Inc. (NasdaqGS: ABAX ), a ... the medical, research, and veterinary markets worldwide and providing ... in the United States , announced ... acquire 100% of QCR & Trio Diagnostics Limited, a ... The transaction closed on November 17, 2014. ...
Breaking Medicine Technology:Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 2New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 3Abaxis Acquires UK-based Distribution Organization 2Abaxis Acquires UK-based Distribution Organization 3Abaxis Acquires UK-based Distribution Organization 4
Cached News: