HOME >> MEDICINE >> NEWS
Proteins found in urine of pregnant women could help diagnose preeclampsia

Researchers at Yale School of Medicine have found that specific substances in the urine of pregnant women could serve as a screening/diagnostic tool for preeclampsia (hypertension and proteinuria during pregnancy).

The study is published in March issue of American Journal of Obstetrics and Gynecology.

"Preeclampsia is one of the most common causes of maternal mortality in the United States, but establishing a correct diagnosis can be very difficult, especially in women with hypertension prior to pregnancy," said lead author Catalin Buhimschi, M.D., assistant professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine.

Buhimschi and his colleagues developed a new algorithm to calculate the ratio for the presence or absence of three specific proteins that are normally secreted by human placenta. They examined samples of urine and blood from 132 women, some of whom had other causes of hypertension. The ratio between two of the proteins correctly identified all the women who had severe preeclampsia.

"It will take several years to develop a new diagnostic test," said Buhimschi. "Many factors are present in the serum and blood, but only the relationship between them has diagnostic significance."

The proteins studied were vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their soluble VEGF receptor (sFlt1). The ratio of sFlt1 and PlGF had a high sensitivity (88 percent) and specificity (100 percent) for identifying severe preeclampsia, and was more accurate than proteinuria alone.

Buhimschi said current tests such as liver function, proteinuria and platelet count are neither accurate nor sensitive, and results can be confusing, placing women at risk of giving birth prematurely. The current treatment is delivery of the fetus regardless of gestational age. These results provide scientists with a better understanding of the mechanisms of preeclamp
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
7-Mar-2005


Page: 1 2

Related medicine news :

1. Wistar Scientist Awarded American Cancer Society Grant For Study Of Tumor Suppressor Proteins
2. Acupuncture found to lower elevations in blood pressure
3. Potential drug target for treating cocaine abuse found
4. Similar results found in both older and younger patients undergoing weight-loss surgery
5. Infectious agent linked to mad cow disease found in organs other than the brain
6. Generation gap found in chronic pain
7. A site for sore eyes: New target for allergies found under the eyelid
8. Chemicals found in cherries may help fight diabetes
9. Thanks for the memories: cinematic portrayal of amnesia is profoundly misleading
10. Very high prevalence of virus linked to cervical cancer found in adolescent women
11. Two-fisted assault on dopamine transport system may be foundation of Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/7/2020)... ... January 07, 2020 , ... Twenty-six people, all but one who live ... others living with YOPD attend the 6th World Parkinson Congress. The participants, representing ... back to cover all 52 weeks in 2020. The group aims to raise at ...
(Date:1/7/2020)... (PRWEB) , ... January 06, 2020 , ... ... adults living with memory impairment, has announced the Best Memory Care Facilities in ... to experts, facility features and amenities. , According to the Alzheimer’s ...
(Date:1/7/2020)... ... , ... R3 Stem Cell is now offering access to all regenerative training ... 24/7 and includes all the stem cell and exosome courses. , For several years, ... For the online regenerative training courses, R3 assembled all of the presentations and procedures ...
(Date:1/5/2020)... ... January 04, 2020 , ... Urban Air, the premier family-friendly indoor trampoline ... company known for endless hours of trampolining, rock climbing, dodge-balling and more, has announced ... Creek, Frederick, MD. , “We know families are looking for ways to spend time ...
(Date:1/3/2020)... ... January 03, 2020 , ... Liz ... Association® Board of Directors (ALCA). Aging Life Care Professionals® have advanced degrees and ... adults and the disabled, and work with the family to provide recommendations for ...
Breaking Medicine News(10 mins):
(Date:1/2/2020)... ... , ... In an age of the current mental health crisis, it’s a ... to embrace acceptance and understanding of the needs of atypical’s that are one of ... train, a new story that represents the Children’s First Mental Health Primer. Come aboard ...
(Date:1/1/2020)... ... 2020 , ... Wireless Zone®, a Verizon authorized retailer and ... Foundation through its philanthropic Wireless Zone Foundation for Giving®. The check presentation took ... on October 7, 2019. The Children’s Tumor Foundation is one of the Wireless ...
(Date:12/31/2019)... ... December 31, 2019 , ... NeoTract, a wholly ... field of urology, today announced that Dr. Vi Hua MD Valley Urologic Associates ... designation recognizes that Dr. Hua has achieved a high level of training and ...
Breaking Medicine Technology:
Cached News: