HOME >> MEDICINE >> NEWS
Proteins found in urine of pregnant women could help diagnose preeclampsia

Researchers at Yale School of Medicine have found that specific substances in the urine of pregnant women could serve as a screening/diagnostic tool for preeclampsia (hypertension and proteinuria during pregnancy).

The study is published in March issue of American Journal of Obstetrics and Gynecology.

"Preeclampsia is one of the most common causes of maternal mortality in the United States, but establishing a correct diagnosis can be very difficult, especially in women with hypertension prior to pregnancy," said lead author Catalin Buhimschi, M.D., assistant professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine.

Buhimschi and his colleagues developed a new algorithm to calculate the ratio for the presence or absence of three specific proteins that are normally secreted by human placenta. They examined samples of urine and blood from 132 women, some of whom had other causes of hypertension. The ratio between two of the proteins correctly identified all the women who had severe preeclampsia.

"It will take several years to develop a new diagnostic test," said Buhimschi. "Many factors are present in the serum and blood, but only the relationship between them has diagnostic significance."

The proteins studied were vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their soluble VEGF receptor (sFlt1). The ratio of sFlt1 and PlGF had a high sensitivity (88 percent) and specificity (100 percent) for identifying severe preeclampsia, and was more accurate than proteinuria alone.

Buhimschi said current tests such as liver function, proteinuria and platelet count are neither accurate nor sensitive, and results can be confusing, placing women at risk of giving birth prematurely. The current treatment is delivery of the fetus regardless of gestational age. These results provide scientists with a better understanding of the mechanisms of preeclamp
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
7-Mar-2005


Page: 1 2

Related medicine news :

1. Wistar Scientist Awarded American Cancer Society Grant For Study Of Tumor Suppressor Proteins
2. Acupuncture found to lower elevations in blood pressure
3. Potential drug target for treating cocaine abuse found
4. Similar results found in both older and younger patients undergoing weight-loss surgery
5. Infectious agent linked to mad cow disease found in organs other than the brain
6. Generation gap found in chronic pain
7. A site for sore eyes: New target for allergies found under the eyelid
8. Chemicals found in cherries may help fight diabetes
9. Thanks for the memories: cinematic portrayal of amnesia is profoundly misleading
10. Very high prevalence of virus linked to cervical cancer found in adolescent women
11. Two-fisted assault on dopamine transport system may be foundation of Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2016)... ... April 30, 2016 , ... Create an abstract ... can distort and manipulate three-dimensional shapes with ease all within Apple Motion ... lines, polygons, polygon texture animation, opacity texture animation, overall shape texture displacement, twist, ...
(Date:4/30/2016)... ... April 30, 2016 , ... Dr. ... CEO of EMED, today signed a multifaceted agreement which will allow for the ... Caribbean University Department of Natural and Applied Sciences, Allied Health and Nursing will ...
(Date:4/29/2016)... , ... April 30, 2016 , ... ... of patented products, announces the Pick Up Springboard, an automotive invention that improves ... Truck Manufacturing industry is worth $162 billion," says Scott Cooper, CEO and Creative ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... Accreditation Council for Graduate Medical Education (ACGME) that it has received accreditation for ... first accreditation of three residency programs that Memorial is currently pursuing, including Pediatrics ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... of our nation’s productivity, stability, even security. Most importantly, employees are the single ... Then why are American workers so unhappy? , Just under half of American ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 27, 2016 Global  urinalysis ... billion by 2022, according to a new report ... (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... efficiency and accuracy delivered by the new generation ... novel urinalysis instruments and consumables. For instance, the ...
(Date:4/27/2016)... -- At the Sachs CEO forum in ... 2 clinical study of its lead drug candidate, STR001, ... (CI) surgery. This large, placebo-controlled, double-blind, phase 2 study ... and France . STR001 is ... of surgery. "Despite advances in cochlear implant technology, a ...
(Date:4/26/2016)... , April 26, 2016 Hill-Rom Holdings, Inc. ... a management presentation at the Deutsche Bank 41 st ... 2:50 p.m. EDT. You are invited to listen ... http://ir.hill-rom.com/events.cfm or access it directly at http://edge.media-server.com/m/p/mr4uxgas . ... hour after conclusion of the live event and accessible at ...
Breaking Medicine Technology:
Cached News: