HOME >> MEDICINE >> NEWS
Proteins found in urine of pregnant women could help diagnose preeclampsia

Researchers at Yale School of Medicine have found that specific substances in the urine of pregnant women could serve as a screening/diagnostic tool for preeclampsia (hypertension and proteinuria during pregnancy).

The study is published in March issue of American Journal of Obstetrics and Gynecology.

"Preeclampsia is one of the most common causes of maternal mortality in the United States, but establishing a correct diagnosis can be very difficult, especially in women with hypertension prior to pregnancy," said lead author Catalin Buhimschi, M.D., assistant professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine.

Buhimschi and his colleagues developed a new algorithm to calculate the ratio for the presence or absence of three specific proteins that are normally secreted by human placenta. They examined samples of urine and blood from 132 women, some of whom had other causes of hypertension. The ratio between two of the proteins correctly identified all the women who had severe preeclampsia.

"It will take several years to develop a new diagnostic test," said Buhimschi. "Many factors are present in the serum and blood, but only the relationship between them has diagnostic significance."

The proteins studied were vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their soluble VEGF receptor (sFlt1). The ratio of sFlt1 and PlGF had a high sensitivity (88 percent) and specificity (100 percent) for identifying severe preeclampsia, and was more accurate than proteinuria alone.

Buhimschi said current tests such as liver function, proteinuria and platelet count are neither accurate nor sensitive, and results can be confusing, placing women at risk of giving birth prematurely. The current treatment is delivery of the fetus regardless of gestational age. These results provide scientists with a better understanding of the mechanisms of preeclamp
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
7-Mar-2005


Page: 1 2

Related medicine news :

1. Wistar Scientist Awarded American Cancer Society Grant For Study Of Tumor Suppressor Proteins
2. Acupuncture found to lower elevations in blood pressure
3. Potential drug target for treating cocaine abuse found
4. Similar results found in both older and younger patients undergoing weight-loss surgery
5. Infectious agent linked to mad cow disease found in organs other than the brain
6. Generation gap found in chronic pain
7. A site for sore eyes: New target for allergies found under the eyelid
8. Chemicals found in cherries may help fight diabetes
9. Thanks for the memories: cinematic portrayal of amnesia is profoundly misleading
10. Very high prevalence of virus linked to cervical cancer found in adolescent women
11. Two-fisted assault on dopamine transport system may be foundation of Parkinsons disease

Post Your Comments:
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
(Date:1/14/2014)... -- Luminex Corporation (Nasdaq: LMNX ) today announced ... quarter of 2013 on Monday, February 3, 2014. A ... after the close of trading. (Logo: ... conference call to discuss the operating highlights and financial ... December 31, 2013 on February 3, 2014, at 5:00 ...
(Date:1/14/2014)... -- Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company of ... Home Medical Equipment, Inc. ("Progressive") of Clarion, PA ... acquisition were not disclosed. Progressive is a ... range of sleep, mobility, and respiratory products to customers in ... Pittsburgh markets. Progressive was founded in 2005 by ...
(Date:1/14/2014)... PLYMOUTH, Minn. , Jan. 14, 2014   NuAire ... for research, have come to agreement with Hitachi Koki ... service the Hitachi brand of centrifuges in North ... professionals throughout the United States and ... use, product benefits and features, options and accessories, training, pricing, ...
Breaking Medicine Technology:Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3NuAire announces sales and service of Hitachi Koki centrifuges in North America 2
Cached News: