Radically new anti-rejection drug shown to offer safe control of immune system in Stanford study

me. They identified a promising molecule and then chemically modified it to produce CP-690,550, which turned out to be extremely potent in blocking JAK3 with little effect on closely related enzymes.

Pfizer has found that the drug is well-tolerated in healthy human volunteers, and has begun testing it as a treatment for psoriasis, an autoimmune condition in which skin cells grow more quickly than normal. "If we verify in humans that the side effects are minimal, then it may turn out that the drug could be used to treat a variety of autoimmune diseases in which the immune system needs to be controlled, and not just organ transplant recipients," Borie said.


Contact: Mitzi Baker
Stanford University Medical Center

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