Raloxifene following tamoxifen may offer no more reduction in breast cancer risk

A new study done in mice suggests that taking raloxifene after 5 years of tamoxifen therapy may not further prevent the growth of breast cancers. What's more, raloxifene may stimulate the growth of endometrial tumors, conclude Ruth M. O'Regan, M.D., and V. Craig Jordan, Ph.D., D.Sc., of Northwestern University Medical School, Chicago, and their colleagues in the Feb. 20 issue of the Journal of the National Cancer Institute.

Adjuvant therapy with the selective estrogen receptor modulator tamoxifen helps some women with early-stage breast cancer reduce their risk of recurrence. But some studies have suggested this benefit levels off after 5 years, and further treatment with tamoxifen not only doesn't help, it may increase a woman's risk of endometrial cancer.

To get around this, researchers have suggested following a 5-year tamoxifen treatment with the SERM raloxifene, a drug used to prevent osteoporosis in postmenopausal women. Results from a large randomized clinical trial of raloxifene suggested that the drug may decrease a woman's risk of breast cancer without increasing her risk of endometrial cancer.

However, the new study suggests that raloxifene after tamoxifen may not be beneficial. O'Regan and her colleagues exposed breast and endometrial tumors in mice to combinations of estrogen, tamoxifen, and raloxifene or nothing at all. The authors found that raloxifene did not further prevent the growth of breast tumors previously exposed to more than 5 years of tamoxifen. Furthermore, raloxifene did not block the growth of endometrial tumors caused by low-dose estrogen. The authors conclude that treatment with raloxifene after 5 years of tamoxifen treatments may not further decrease breast cancer recurrence and may increase the incidence of endometrial cancer.

These findings "do not support an optimistic future for the use of raloxifene as a replacement for tamoxifen after 5 years of adjuvant therapy," says Michael B. Sporn, M

Contact: Linda Wang
Journal of the National Cancer Institute

Page: 1 2

Related medicine news :

1. Raloxifene after tamoxifen not beneficial
2. University of Pittsburgh-led study confirms that Raloxifene protects post-menopausal women from invasive breast cancer
3. Osteoporosis Drug Evista (Raloxifene) Cuts Newly Diagnosed, Invasive Breast Cancer Risk By More Than 60 Percent
4. V. Craig Jordan Will Present Results Of Raloxifene Breast Cancer Study At American Society For Clinical Oncology Meeting
5. US FDA grants full approval to DOXIL(R) following submission of phase III data
6. Patients with abdominal trauma at risk for intra-abdominal infections following surgery
7. Guidelines for following pediatric cancer survivors aim to reduce medical complications
8. Can the standard course of radiation therapy following lumpectomy be shortened?
9. Higher incidence of rejection following early steroid withdrawal
10. Impaired neuromotor function following cancer treatment can improve
11. Significant pain relief following gastric bypass surgery

Post Your Comments:

(Date:8/31/2020)... , ... August 31, 2020 , ... ... Network (AHN), are joining biomedical engineers from Carnegie Mellon University (CMU) to develop ... cardiac patients who have undergone open heart surgery. , The AGH/CMU team was ...
(Date:8/31/2020)... ... August 31, 2020 , ... Just found out your dear friend has cancer? , It’s ... friend or family member shares their diagnosis. Once the shock wears off, the questions and ... thing? What are the best ways to help? Words are failing me. I’m scared. I ...
(Date:8/31/2020)... ... , ... Want to get moving, break up your routine, and make a ... to launch its fourth annual STEPtember campaign in the United States to raise funds ... they are at this moment — encouraging people to move in the ways that ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... higher-learning opportunities through high-quality, career-relevant, and affordable online education – is proud to ... , Among the first of its kind in the nation, the 60-credit ...
(Date:8/31/2020)... LAWRENCEVILLE, Ga. (PRWEB) , ... August 31, 2020 , ... The pandemic and topsy-turvy economic ... to examine our budgets and look for ways to trim the fat from our monthly ... stabilize your finances, but it’s also important that you have a financial safety net in ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... Neil Oberfeld ... as Secretary to the Board of Trustees and committee chair of the Governance ... is a Denver-based nonprofit organization that fights for the education, health, and financial ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... today announced that they have invested $400,000 in PopBase, one of two start-ups ... with the Global Wellness Institute (GWI). , The competition was part of ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... primary care medical centers in Florida and San Antonio is happy to announce ... Texas medical centers. , In this capacity he will serve as community advisor, ...
Breaking Medicine Technology:
Cached News: