HOME >> MEDICINE >> NEWS
Randomisation phase of the DIRECT programme (DIabetic REtinopathy Candesartan Trials) completed

The randomisation of patients into the landmark DIabetic REtinopathy Candesartan Trials (DIRECT) was completed in February. A total of 5238 patients in around 300 investigational sites in 30 EU countries have now been randomised into the 3 trial/studies that comprise the DIRECT Programme. The DIRECT Programme is the first Programme designed to establish whether treatment with an angiotensin II type 1 (AT1) receptor blocker, candesartan cilexetil, targeting the renin angiotensin system (RAS), can provide effective treatment against the onset and progression of diabetic retinopathy. In this double-blind programme, patients are assigned to receive 32 mg of candesartan cilexetil or placebo.

The DIRECT programme, launched on Nov. 1, 2000, is being coordinated through EURODIAB, a European diabetes research network, based at University College, London, and Imperial College, London, and overseen by an independent Steering Committee, chaired by Professor Anne-Katrin Sjolie, University of Southern Denmark, Odense. The Steering Committee consists of leading ophthalmologists, diabetologists and epidemiologists, and has scientific responsibility for the DIRECT programme.

"We are very pleased to have completed this initial phase of the DIRECT Programme, with more patients than originally planned. DIRECT represents an important step forward in the fight against visual loss caused by diabetic retinopathy", said Professor Sjolie. "This important Programme will tell us more about the potential for using a drug such as candesartan to halt progression of, and possibly prevent, diabetic retinopathy, a common and frightening condition among people with diabetes. We look forward to the results from the DIRECT Programme, which will hopefully identify candesartan as a new addition to current treatment and help to limit retinal damage and, in some patients, preserve vision."

Retinopathy can ultimately lead to blindness in both type 1 and type 2 diabetic patients. I
'"/>

Contact: Takashi Kikuchi
Kikuchi_Takashi@takeda.co.jp
81-66-204-2258
Japan Corporate News Network
2-Mar-2004


Page: 1 2 3

Related medicine news :

1. US FDA grants full approval to DOXIL(R) following submission of phase III data
2. Less risks for patients participating in early phase cancer drug trials
3. Zengen reports positive phase I/II trial results of its peptide molecule for vaginal yeast infection
4. Exemestane beats tamoxifen in first phase III head to head trial in advanced breast cancer
5. New vaccine for herpes in final trial phase
6. Antiepileptic drug developed at Hebrew University to undergo phase three clinical trials
7. Exanta - pivitol data from largest ever phase III stroke prevention trial announced at ACC
8. Results of NUVANCE phase I/II asthma trial presented
9. Circulation publishes phase I study of ENBREL in patients with chronic heart failure
10. Influenza vaccination programmes for children in USA and Canada based on little evidence
11. New programme will train the next generation of health leaders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2019)... ... June 25, 2019 , ... ... providing business support services to more than 400 affiliated offices across 17 states, ... Mission Viejo, California. , Smile Brands will provide full-service administrative support to the ...
(Date:6/24/2019)... , ... June 24, 2019 , ... Cibo Vita, Inc., ... its new Nature’s Garden functional and healthy indulgence snack line at the 65th annual ... 23-25. , Find Cibo Vita at booth #5721. , The company’s expansive ...
(Date:6/24/2019)... ... ... Exercising on hard, solid surfaces can be extremely difficult on joints and ... softer surfaces, such as on a treadmill that has built-in shock absorption, or on ... to have shock-absorption benefits with a step platform too? With Billy’s Boomboxing ...
(Date:6/20/2019)... OKLAHOMA CITY, Okla. (PRWEB) , ... June 20, ... ... provider, is pleased to announce their partnership with Physical Therapy Solutions in Lawton, ... Street, Suite C, the clinic is the group’s 28th clinic in the state. ...
(Date:6/19/2019)... ... June 19, 2019 , ... The number of public ... national standards of performance continues to climb. Today, the Public Health Accreditation ... local governmental public health departments. With this week's accreditation decisions, tens of thousands ...
Breaking Medicine News(10 mins):
(Date:6/19/2019)... ... June 19, 2019 , ... Center for Vein Restoration (CVR) CEO and ... Top CEOs in 2019 . Glassdoor , one of the world’s largest ... world-class leaders that employees love working for throughout North America and parts of Europe. ...
(Date:6/19/2019)... ... 19, 2019 , ... A new survey by The Senior Citizens League ... on healthcare costs. If that doesn’t sound like enough of a challenge, at ... survey participants reported spending $1,000 per month or more. The same survey also ...
(Date:6/18/2019)... LOS ANGELES (PRWEB) , ... June 18, 2019 ... ... doors of its new facilities at 11500 W Olympic Blvd Suite 350 Los ... functioning disorders through research-backed methodologies. , MY Education Guru has created ...
Breaking Medicine Technology:
Cached News: