HOME >> MEDICINE >> NEWS
Rasagiline reduces disability for patients with advanced Parkinson's disease

This release is also available in German.

Giving Parkinson's patients on levodopa treatment an additional drug called rasagiline once daily can improve their motor function, concludes a study published in this week's issue of THE LANCET.

Most patients with established Parkinson's disease receiving long-term treatment with levodopa will eventually have motor fluctuations, defined as periods of the day with poor or absent motor response to their medication (off-time) alternating with periods of clearly improved motor function (on-time). Several drugs (pergolide, pramipexole, ropinirole, entacapone and tolcapone) when added to levodopa have been effective in the management of fluctuations but these drugs only provide partial improvement, leaving patients with clinically significant off-periods, while adding complexity to the treatment schedule. Preliminary data shows that the additional use of rasagiline may be useful in the treatment of advanced Parkinson's disease.

Olivier Rascol (University Hospital, Toulouse, France) and colleagues recruited 687 patients from 74 hospitals and centres in Israel, Argentina, and Europe. 231 individuals were assigned to receive 1mg of oral rasagiline once daily, 227 to entacapone (200mg with every levodopa dose) and 229 to a placebo. Both rasagiline and entacapone reduced average daily off-time (-1.18 hours for rasagiline and V1.2 hours for entacapone) when compared with placebo. Rasagiline had a safety profile similar to that of the placebo and its once daily regimen was convenient to administer. The drug was well tolerated in the old-age group (d70).

Professor Rascol states: "This study has shown that rasagiline is an effective, safe and simple treatment for Parkinson's disease when used in combination with levodopa. Rasagiline achieved the two main goals of treatment after levodopa -- reduced disability and decreased motor f
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
10-Mar-2005


Page: 1 2

Related medicine news :

1. Geodon effective in psychiatric emergencies; Sharply reduces time in restraints
2. Targeting mutant B-Raf protein reduces melanoma development
3. Breast cancer treatment reduces risk of heart disease
4. Carrot component reduces cancer risk
5. Sex hormone metabolite reduces stress, anxiety in female rats
6. Sunlight reduces risk of lymph gland cancer
7. Male circumcision reduces risk of HIV transmission from women to men
8. Surgical treatment of migraines reduces sick days and increases employee productivity ASPS study
9. Novel p53 gene-based therapy boosts immune system and reduces tumor size
10. VGTI researchers help uncover why aging reduces immune system function
11. Early detection reduces threat of foot injury in college basketball players

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 31, 2020 , ... Dentists Drs. ... The Dental Studio of Midland for groundbreaking laser dentistry treatment whether ... patients are able to experience the many advantages of laser dentistry including less ...
(Date:7/22/2020)... ... July 22, 2020 , ... With Covid-19 and ... the world has changed, and there’s no going back. In confronting our discomfort ... help us temporarily manage emotional struggles, healing is the approach we should strive ...
(Date:7/18/2020)... ... July 17, 2020 , ... HMI Performance Incentives’ ... Creative Awards, was a charitable push put together to help spread positivity in ... during the pandemic, HMI asked individuals in its audience to share stories, answering ...
(Date:7/18/2020)... ... July 18, 2020 , ... The Dentists, LLC is ... Jersey community for over 35 years. NJ Top Dentists, Dr. Georgette Bennardo-Meggelin and Dr. ... provide you with exceptional dentistry. , “We are committed to making our patients’ treatment ...
(Date:7/10/2020)... TROY, Mich. (PRWEB) , ... July 10, 2020 ... ... can be overwhelming for people with spinal cord disease or injury and social ... the COVID-19 pandemic can induce symptoms of anxiety, depression, distress, and PTSD amongst ...
Breaking Medicine News(10 mins):
(Date:7/18/2020)... ... July 17, 2020 , ... The Women’s Fund Miami-Dade has ... those who are experiencing abuse know that services are available 24/7, and to ... Miami-Dade County’s Coordinated Victim’s Assistance Center (CVAC) helpline. Although there hasn’t been an ...
(Date:7/10/2020)... ... July 10, 2020 , ... Precision ADM, Inc. ... solutions provider today announced that their CANSWAB™ nasopharyngeal swabs are the first Canadian-made ... a new 3D-printed swab design and has trademarked the name CANSWAB™ for distribution. ...
(Date:7/10/2020)... ... 09, 2020 , ... The team at The Keyhole Heart Clinic ... The new site offers a multitude of user enhancements and streamlined navigation for a ... easy to navigate menus which will allow patients to find the information they need ...
Breaking Medicine Technology:
Cached News: