HOME >> MEDICINE >> NEWS
Rat Studies At Yale University School Of Medicine Suggest A New Class Of Medications For Treating Schizophrenia

New Haven, Conn. -- A drug that lowers brain levels of the chemical glutamate -- one of the neurotransmitters responsible for relaying messages between neurons -- can reverse symptoms of a rat model of schizophrenia without apparent side effects, according to a Yale University School of Medicine study.

The research, published in the Aug. 28 issue of the journal Science, suggests a possible new class of medications that could be effective in treating schizophrenia and other psychiatric disorders, such as addiction, which are thought to be associated with abnormal glutamate-mediated neurotransmission.

The study was conduced by Bita Moghaddam, associate professor of psychiatry and neurobiology at Yale School of Medicine, and research associate Barbara W. Adams.

Rats under the influence of PCP, a hallucinogen also known as "angel dust" that causes schizophrenia-like symptoms in healthy people, developed symptoms such as frantic running, incessant head-rolling, and disturbances in memory and attention that are thought to parallel symptoms of schizophrenia in humans. By using a drug that stimulates a specific type of glutamate receptor, the Yale researchers succeeded in reversing these behavioral effects of PCP.

The promising new compound used in the Yale study, called LY354740, is being developed by Eli Lilly & Co. in Indianapolis for treating anxiety and other psychiatric disorders. The drug lowered abnormally high levels of glutamate in the PCP-treated rats by stimulating a subgroup of the metabotropic glutamate receptors (mGluRs). As glutamate levels fell, the rats showed improved working memory and reduced locomotion and head-rolling, Moghaddam reported. The drug worked at a dose that did not reduce brain levels of dopamine, an essential neurotransmitter that is the target of existing medications for schizophrenia.


'"/>

Contact: Cynthia Atwood
cynthia.atwood@yale.edu
203-432-1345
Yale University
27-Aug-1998


Page: 1 2

Related medicine news :

1. Studies underscore genetic involvement in nicotine addiction & aggressive hostility
2. Studies address issues of risk and survival in rapidly increasing GI cancers
3. Studies examine coffee drinking and risk of liver and colorectal cancers
4. Studies reveal physicians attitudes on end-of-life care
5. Studies from the November issue of The Archives of Dermatology, a theme issue on facial rejuvenation
6. Studies link obesity to increased frequency of heartburn symptoms; greater risk of esophageal cancer
7. Studies demonstrate positive data in treatment of hepatitis C
8. Studies examine risk factors and potential consequences associated with prehypertension
9. Studies show ACTOS(R) (pioglitazone HCl) has positive effects on various components of dyslipidemia
10. Studies identify risk factors for colon cancer
11. Studies indicate healthy eating may affect cancer development, improve digestive system

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... BluePearl Specialty and Emergency ... Prevention’s (AFSP) annual signature event, Out of the Darkness (OOTD), which unites more ... raise awareness of suicide prevention. To ensure Associate safety, BluePearl will not be ...
(Date:9/2/2020)... ... September 02, 2020 , ... RAM Technologies, Inc., the perennial ... and Special Needs plans, is proud to support the 2020 National Conferences on ... is supporting the event as a sponsor and exhibitor and will be showcasing ...
(Date:9/1/2020)... ... September 01, 2020 , ... Dr. Kiran Gill is ... surgery of the face, breast, and body. In 2018, she founded Aesthetics in ... surgery and aesthetic practice in Southwest Florida. Dr. Gill and her team offer ...
(Date:8/31/2020)... , ... August 31, 2020 , ... Want to get ... Cerebral Palsy Alliance Research Foundation (CPARF) is thrilled to launch its fourth annual STEPtember ... A fully virtual challenge, STEPtember meets everyone wherever they are at this moment — ...
(Date:8/31/2020)... ... ... “PTS” with Mediation & Hypnosis , At this very turbulent time in the world, ... immense stress, and right now are needing serious relief from a constant state of endless ... experiencing a great degree of emotional discomfort, be it fear or worrying about their income ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... ... September 03, 2020 , ... Using Analysis of Variance — A Practical ... 2020, 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/anova , How much would it help ... one can’t become one in 90 minutes, one can master a powerful statistical technique ...
(Date:9/1/2020)... SANTA CLARA, Calif. (PRWEB) , ... September 01, ... ... diagnostics, and analytical laboratory technologies, will host the Agilent Science and Technology ... , During this two-day symposium, Agilent will open a suite of Live webinars ...
(Date:9/1/2020)... ... ... September is National Ovarian Cancer Awareness Month. Ovarian cancer is the ... the female reproductive system. The American Cancer Society estimates that in 2020, about ... from this disease. Throughout the month of September, Women’s Excellence aims to increase ...
Breaking Medicine Technology:
Cached News: