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Reduced risk of institutionalisation in patients with dementia

s long as possible is very important. This retrospective study suggests that long-term treatment with galantamine may significantly delay the need for residential or nursing home care, prolonging independence and the time patients can spend at home with their families."

Unlike previous pharmaco-economic studies of galantamine, which were based on long-term projections from results of short-term clinical trials, these analyses employed data from long-term studies. The results of this retrospective study are consistent with a similar study on nursing home admission carried out in the USA, suggesting that long-term treatment with galantamine may be associated with a reduced risk of institutionalisation.

Dementia, a progressive brain dysfunction, leads to a gradual loss of the ability to carry out daily activities. The most common and well-known type of dementia is Alzheimer's disease, affecting cognitive function (ability to think, reason and learn), personality and behaviour. Alzheimer's disease is the fourth-leading cause of death in Western countries, preceded only by myocardial infarction, cancer and stroke.6

Alzheimer patients are often admitted to a nursing home when they have become totally reliant on a caregiver, often a family member for day-to-day care. At this stage, the burden of care is so extensive that caregivers can no longer cope with the day-to-day commitment required for such an emotionally and physically demanding job.

Experts believe the long-term clinical efficacy of galantamine may be a result of its unique dual mode of action: like other Alzheimer's disease treatments, galantamine enhances levels of the neurotransmitter acetylcholine (a chemical 'messenger' responsible for sending signals between nerve cells in the brain), which is typically deficient in Alzheimer's disease. However, unlike other treatments, galantamine also has a unique modulating effect on the brain's nicotinic receptor
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Contact: Hayley Baruch
hayley.baruch@resolutecommunications.com
Resolute Communications
9-Nov-2004


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