HOME >> MEDICINE >> NEWS
Reducing side effects of retinoic acid cancer treatment

ITHACA, N.Y. -- For some time doctors have been using a vitamin A derivative, retinoic acid (RA), to treat several cancers, particularly prostate cancer and leukemia, and they are now experimenting with the drug to treat breast cancer. The great drawback to RA, however, is that it requires high levels of the medication in order to turn genes "on" and "off," often triggering devastating and potentially fatal side effects.

Now, a Cornell University biochemist has learned how to make tumor cells up to 1,000 times more sensitive to RA so that much smaller doses would be required to flick the "on" and "off" switch (a process known as the induction of gene expression).

"This novel strategy for regulating the anticarcinogenic activity of retinoic acid has potential not only for treating tumors but also, perhaps, for protecting high-risk patients preventively," says Noa Noy, a professor of nutritional sciences at Cornell. "We have discovered that a naturally occurring protein in the cell can dramatically enhance the ability of RA to inhibit the proliferation of breast cancer cells, so that much less RA -- perhaps even the amount naturally present in the body -- is required to suppress tumor development."

The new findings are described in two recent articles in Molecular and Cellular Biology (April and July 2002).

RA belongs to a class of compounds known as retinoids that play key roles in regulating gene transcription and, therefore, govern multiple functions in the body, such as cell division and differentiation, immune response and embryonic development. They also control the development and spread of cancer cells, and some, including RA, can inhibit tumor growth by preventing cancer cell proliferation. Retinoids are now in clinical trials for treatment of head, neck and breast cancers, as well as for diabetes, arteriosclerosis and emphysema.

In the body, RA activates a protein in cells known as retinoic acid receptor (RAR) that binds
'"/>

Contact: Susan S. Lang
SSL4@cornell.edu
607-255-3613
Cornell University News Service
13-Aug-2002


Page: 1 2 3

Related medicine news :

1. Reducing hostility in young coronary artery disease patients is important piece of rehabilitation
2. Reducing anti-rejection meds after transplant shows less complications
3. Reducing the number of walk-in patients wont help solve emergency department overcrowding: Study
4. Reducing hypertension in the elderly leads to a significant reduction in the incidence of stroke
5. Reducing antiepileptics in VNS (TM) patients does not impair seizure control
6. Reducing postoperative nausea and vomiting
7. Reducing the risk of medication errors: Announcing the Penn Center for Patient Safety Research and Practice
8. Reducing your risk of breast and ovarian cancer topic of womens cancer conference
9. Reducing the costs of diabetes in Europe: Preventing complications is the key
10. Nurse Practitioners Reducing Costs, Expanding Care
11. Paying Attention To High Blood Pressure Programs A Good Investment In Reducing Stroke Risk

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/24/2018)... ... September 24, 2018 , ... On September 15, Castle Dental® in Austin, ... need from their surrounding communities. Over 40 volunteers from neighboring Castle Dental offices arrived ... dentist in years. , Smiles for Everyone Foundation partnered with local nonprofit organizations ...
(Date:9/24/2018)... (PRWEB) , ... September 24, 2018 , ... As a ... help their respective patients, clients, and students improve their movement or mobility and strength ... Mike Moran to OS Instructor status. Mike is a Coach/Instructor at Tucson Strength ...
(Date:9/24/2018)... ... September 24, 2018 , ... Paris-based My Cuistot ... Its roster of talented chefs works constantly to create innovative, balanced meals, which ... to its standard weekly meals, My Cuistot is happy to customize its meal ...
(Date:9/22/2018)... ... September 21, 2018 , ... Liz Dudek, Director of Health Care Affairs for ... Chapter meeting of the Florida Assisted Living Association (FALA) at 10:00 a.m. at Tessera ... will provide an overview of the success of the first five years of Florida’s ...
(Date:9/22/2018)... ... September 22, 2018 , ... ... exclusively to funding innovative lymphoma research and serving the lymphoma community through a ... its 12th annual Lymphoma Research Ride, a cycling event held each year during ...
Breaking Medicine News(10 mins):
(Date:9/12/2018)... (PRWEB) , ... September 12, 2018 , ... Lifetime ... senior living communities, announces the launch of a new online store to offer exclusive ... all ages. , “We’re thrilled to open our online store to offer our ...
(Date:9/7/2018)... ... September 06, 2018 , ... CTL Medical ... purchase its commercial spine business, which includes its complete portfolio of spine-related patents ... that result from it. The deal will make CTL Medical the world’s exclusive ...
(Date:9/7/2018)... ... September 07, 2018 , ... New York City is currently the ... gather in hopes of claiming the fourth and final jewel in the 2018 grand ... and vicious volleys. Seldom, however, will the players’ footwork be highlighted. , “Today’s tennis ...
Breaking Medicine Technology:
Cached News: