HOME >> MEDICINE >> NEWS
Regeneration of insulin-producing islets may lead to diabetes cure

Cells from an unexpected source, the spleen, appear to develop into insulin-producing pancreatic islet cells in adult animals. This surprising finding from Massachusetts General Hospital (MGH) researchers, published in the Nov. 14 issue of Science, is a followup to the same team's 2001 report of a treatment that cures advanced type 1 diabetes in mice. In discovering the biological mechanism behind that accomplishment, the researchers also have opened a potential new approach to replacing diseased organs and tissues using adult precursor cells.

"We have found that it is possible to rapidly regrow islets from adult precursor cells, something that many thought could not be done," says Denise Faustman, MD, PhD, director of the MGH Immunobiology Laboratory and principal investigator of the study. "By accomplishing effective, robust and durable islet regeneration, this discovery opens up an entirely new approach to diabetes treatment."

David M. Nathan, MD, director of the MGH Diabetes Center, notes, "These exciting findings in a mouse model of Type 1 diabetes suggest that patients who are developing this disease could be rescued from further destruction of their insulin-producing cells. In addition, patients with fully established diabetes possibly could have their diabetes reversed." Nathan has developed a protocol to test this approach in patients, but additional grant support is needed before a clinical trial can begin. Type 1 diabetes develops when the body's immune cells mistakenly attack the insulin-producing islet cells of the pancreas. As islet cells die, insulin production ceases, and blood sugar levels rise, damaging organs throughout the body. In their earlier study, Faustman's team directly attacked this process by retraining the immune system not to attack islet cells. They first used a naturally occurring protein, TNF-alpha, to destroy the mistargeted cells. Then they injected the mice with donor spleen cells from nondiabet
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
13-Nov-2003


Page: 1 2 3 4

Related medicine news :

1. Hunter College Biologist Marie Filbin Identifies Mechanism That Blocks All Inhibitors Of Nerve Regeneration; Breakthrough Reported In Neuron Magazine
2. Early intervention stops damage to insulin-producing cells
3. Studies yield key insights in preventing destruction of insulin-producing cells
4. Waist size linked to diabetes risk in adult men
5. Employees with diabetes are not more tired
6. Compound may help prevent diabetes in fast-food fans
7. Drugs aid weight loss among type 2 diabetes patients
8. Single-donor islet transplantation procedure shows promise for patients with type 1 diabetes
9. Herb used to treat diabetes works like modern-day prescription drugs, study suggests
10. Study shows that diabetes increases risk of blood poisoning
11. Lifestyle changes especially effective at preventing type 2 diabetes in adults aged 60 and older

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Regeneration insulin producing islets may lead diabetes cure

(Date:3/3/2015)... US Air Purifiers LLC , an ... is pleased to announce that all Rabbit brand air purifiers ... to the west coast port strikes. This news comes just ... , The port strikes, which have caused ... quarter economic growth by as much as 1%, have hindered ...
(Date:3/3/2015)... Rhinebeck, NY (PRWEB) March 03, 2015 Topical ... held as a webinar streamed live on Tuesday, March 10th, ... workshops will be archived and accessible 24/7. ... the public. The topic for the March 10th workshop is ... timely discussion, considering that the U.S. represents 5% of the ...
(Date:3/3/2015)... 03, 2015 The combinatorial, multi-gene ... antidepressant treatment outcomes for patients with depression, and ... of the individual genes that comprise the test, ... the Mayo Clinic and Assurex Health, and published ... The proprietary technology of the GeneSight Psychotropic test ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 -- vRad ( Virtual Radiologic ... today announced that Arlene Sussman, MD, a highly regarded ... live webinar to explore how telemedicine best practices allow ... services for women virtually anywhere. Click here ... Line” on March 4, 2015 at 1:00 pm CT. ...
(Date:3/3/2015)... In a segment that aired Monday, March ... Vedantam shared research from the Wharton School ... hand-hygiene compliance that occurs over the course of a healthcare ... in part by alerts on healthcare workers’ badges that remind ... a patient’s room. , “Over the course of a ...
Breaking Medicine News(10 mins):Health News:Rabbit Air Purifiers Back In Stock at US Air Purifiers LLC 2Health News:Rabbit Air Purifiers Back In Stock at US Air Purifiers LLC 3Health News:Topical BioMedics Hosts March Pain Management Webinar 2Health News:Topical BioMedics Hosts March Pain Management Webinar 3Health News:Topical BioMedics Hosts March Pain Management Webinar 4Health News:Topical BioMedics Hosts March Pain Management Webinar 5Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 2Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 3Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 4Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 5Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 6Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 2Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 3Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 4Health News:BIOVIGIL Hygiene Technologies Answers Call for Hand Hygiene Alerts on Badges 2Health News:BIOVIGIL Hygiene Technologies Answers Call for Hand Hygiene Alerts on Badges 3
(Date:3/3/2015)... , Mar. 03, 2015 Research and Markets ... addition of the "Telemedicine and Mobile Healthcare ... 2015 - 2020" report to their offering. ... Health are all terms that pertain to the ... to provide remote clinical/non-clinical healthcare services. They form ...
(Date:3/3/2015)... -- Cyberonics, Inc. (NASDAQ: CYBX ), a global ... of epilepsy, today announced it will participate in the ... in Miami . ... will speak at 1:05 PM Eastern Time.  The session ... no formal materials will be presented.  A live audio ...
(Date:3/3/2015)... , March 3, 2015 Today, the ... sponsored by America,s biopharmaceutical research companies, unveiled a ... functionality to provide patients and caregivers with faster, ... public and private patient assistance programs. ... provided a platform to engage, educate and empower ...
Breaking Medicine Technology:Global Telemedicine and Mobile Healthcare Solutions, Services, and Devices: Market Analysis and Forecasts 2015 - 2020 2Global Telemedicine and Mobile Healthcare Solutions, Services, and Devices: Market Analysis and Forecasts 2015 - 2020 3Partnership for Prescription Assistance Relaunches Website with New Features for Patients and Caregivers 2
Cached News: