HOME >> MEDICINE >> NEWS
Regeneration of insulin-producing islets may lead to diabetes cure

Cells from an unexpected source, the spleen, appear to develop into insulin-producing pancreatic islet cells in adult animals. This surprising finding from Massachusetts General Hospital (MGH) researchers, published in the Nov. 14 issue of Science, is a followup to the same team's 2001 report of a treatment that cures advanced type 1 diabetes in mice. In discovering the biological mechanism behind that accomplishment, the researchers also have opened a potential new approach to replacing diseased organs and tissues using adult precursor cells.

"We have found that it is possible to rapidly regrow islets from adult precursor cells, something that many thought could not be done," says Denise Faustman, MD, PhD, director of the MGH Immunobiology Laboratory and principal investigator of the study. "By accomplishing effective, robust and durable islet regeneration, this discovery opens up an entirely new approach to diabetes treatment."

David M. Nathan, MD, director of the MGH Diabetes Center, notes, "These exciting findings in a mouse model of Type 1 diabetes suggest that patients who are developing this disease could be rescued from further destruction of their insulin-producing cells. In addition, patients with fully established diabetes possibly could have their diabetes reversed." Nathan has developed a protocol to test this approach in patients, but additional grant support is needed before a clinical trial can begin. Type 1 diabetes develops when the body's immune cells mistakenly attack the insulin-producing islet cells of the pancreas. As islet cells die, insulin production ceases, and blood sugar levels rise, damaging organs throughout the body. In their earlier study, Faustman's team directly attacked this process by retraining the immune system not to attack islet cells. They first used a naturally occurring protein, TNF-alpha, to destroy the mistargeted cells. Then they injected the mice with donor spleen cells from nondiabet
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
13-Nov-2003


Page: 1 2 3 4

Related medicine news :

1. Hunter College Biologist Marie Filbin Identifies Mechanism That Blocks All Inhibitors Of Nerve Regeneration; Breakthrough Reported In Neuron Magazine
2. Early intervention stops damage to insulin-producing cells
3. Studies yield key insights in preventing destruction of insulin-producing cells
4. Waist size linked to diabetes risk in adult men
5. Employees with diabetes are not more tired
6. Compound may help prevent diabetes in fast-food fans
7. Drugs aid weight loss among type 2 diabetes patients
8. Single-donor islet transplantation procedure shows promise for patients with type 1 diabetes
9. Herb used to treat diabetes works like modern-day prescription drugs, study suggests
10. Study shows that diabetes increases risk of blood poisoning
11. Lifestyle changes especially effective at preventing type 2 diabetes in adults aged 60 and older

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2016)... ... 31, 2016 , ... Interest is on the rise for using the CRISPR-Cas9 ... tool for RNAi hit validation. A key reason may be that high-throughput synthesis—combined with ... CRISPR RNA (crRNA) collections in arrayed formats. , Arrayed crRNA screens ...
(Date:5/31/2016)... ... May 31, 2016 , ... Dr. Charles A. Ditta attained his Doctor of ... the class of 1986, where he graduated in the top ten percentile of his ... Livingston since 1989. He has been a member in good standing for thirty years ...
(Date:5/30/2016)... (PRWEB) , ... May 30, 2016 , ... As the ... for their children and their efforts to keep their households lice free. , ... Hawaii are enacting new policies that keep kids in the classroom despite the fact ...
(Date:5/29/2016)... ... 2016 , ... Whole Health Supply is happy to announce the favorable reception ... Amazon.com. This new style of nail clipper has a wider jaw opening that is ... and the actual handle is 2.5mm thick to accommodate the cutting force. This is ...
(Date:5/28/2016)... ... May 28, 2016 , ... May 26, 2016- In search ... Fighting Challenge with theme event of “K Warriors” on June 4, 2016 at Ashbury ... , The event is sponsored and hosted by Shaolin Institute and sanctioned by KSF ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... , May 26, 2016 ... Associated With Both Cost Savings and Overall ... plc (LSE: BTG), an international specialist healthcare company, ... at the 21st Annual Meeting of ISPOR (International ... treatment of hepatocellular carcinoma (HCC) using yttrium-90 glass ...
(Date:5/25/2016)... HILDEN , Deutschland und GERMANTOWN, ... Zusammenarbeit mit Therawis bedient ... Entscheidungen bei Brustkrebs   QIAGEN N.V. ... QIA) gab heute bekannt, eine Lizenz- und Entwicklungsvereinbarung ... prädiktiver Assays für die Onkologie eingegangen zu sein. ...
(Date:5/25/2016)... SPRINGS, Florida , May 25, 2016 ... Business Conference & Expo earlier this month, the numbers ... As revenues continue to climb into the billions, more ... the newly released 4th Edition State of Legal Marijuana ... Frontier, a cannabis-focused data-analysis firm, much of the increase ...
Breaking Medicine Technology:
Cached News: