Research leads to more effective methods of treating drug addictions

Jonathan Freedman, Associate Professor of Pharmacology in the Department of Pharmaceutical Sciences at Northeastern Universitys Bouve College of Health Sciences, has discovered why people who suffer from drug addictions or chronic severe pain crave larger dosages of drug treatments over time.

The findings of Professor Freedman and his team resulted from a three-year project funded by the National Institute on Drug Abuse in Bethesda, Maryland. Freedman and his team discovered a specific molecular change in the brain, using a research method called "patch-clamp electrophysiology" on the surface of rat brain cells, one molecule at a time. They found that rats treated with morphine eventually needed higher dosages of drugs to achieve the same effect. Freedman and team hope this understanding will later give way to practical applications in human patients.

"Scientists have been looking for almost 30 years for the molecular mechanism of opiate drug tolerance," says Professor Freedman. "I hope that our discovery will be a significant step towards understanding it. Eventually, we may be better able to treat heroin addicts, and better able to help people like cancer patients who have chronic severe pain."

Professor Freedmans article, "Altered Gating of Opiate Receptor-Modulated K+ Channels on Amygdala Neurons of Morphine-Dependent Rats," was co-authored with Northeastern graduate students Xueguang Chen and Yong-Jian Lin and postdoctoral fellows Hector Marrero and Ricardo Murphy. The article was published in this weeks Proceedings of the National Academy of Sciences.

Boston-based Northeastern University, a private research institution, is a world leader in practice-orientated education. Building on its flagship co-operative education program, Northeastern links classroom learning with workplace experience and integrates professional preparation with study in the liberal arts and sciences.

Representing a wide variety of cultural and ethnic gr

Contact: Laura Schmidt
Northeastern University

Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Research offers hope of new treatments for liver damage
3. Research suggests possible blood test for multiple sclerosis
4. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
5. 2005 Award for Basic Research in Biological Mineralization
6. 2005 Craniofacial Biology Research Award
7. 2005 Research in Dental Caries Award
8. 2005 Research in Prosthodontics and Implants Award
9. 2005 Basic Research in Periodontal Disease Award
10. 2005 Research in Oral Biology Award
11. 2005 Pulp Biology Research Award

Post Your Comments:

(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/28/2020)... ... 28, 2020 , ... Ernst & Young LLP (EY US) ... Of The Year® 2020 Florida Award finalist. Now in its 34th year, the ... growth and prosperity as they build and sustain successful businesses that transform our ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Integrated ... Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air ... airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the filtration ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to increase across ... and community organizations remain closed. Because about 80% of blood donations are made at ... blood donors and blood drive hosts to ensure blood products are readily available for ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... If you live in New York City ... real estate part makes sense, it’s the law of supply and demand, but are plastic ... has a significant percentage of their patients that make the four-hour trip to have ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Dr. ... reproductive and endoscopic surgeon and serves as a clinical professor in the Department of ... of the American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical ...
Breaking Medicine Technology:
Cached News: