Research questions transplant safety procedure

Lyophilization, a method once thought to inactivate retroviruses such as HIV from bones and connective tissues used in transplant procedures, may not be quite as effective as originally thought, researchers at Michigan State University have concluded.

In a paper to be presented at an upcoming meeting of the American Orthopaedic Society for Sports Medicine, MSU scientists said their research shows the method, known as lyophilization or freeze-drying, does not improve the safety of bones and tissues for transplantation, something that could affect thousands of transplant recipients.

"We were able to demonstrate that this type of tissue processing does not inactivate systemically infected tendon and bone tissues," said Steven P. Arnoczky, the Wade O. Brinker Endowed Professor of Surgery in MSU's College of Veterinary Medicine and one of the lead researchers in the project. "Contrary to currently held clinical beliefs, lyophilization should not be relied upon as an extra measure of security for processing connective tissue allografts."

Bones, ligaments and other tissues that will be used for orthopedic transplants frequently are treated with gamma irradiation or a chemical "cocktail" in an effort to remove any bacteria or viruses which may have evaded the rigorous donor-screening process.

However, these methods can create additional problems, as they sometimes change the tissue's biological and biomechanical properties.

A clinical study published in 1985 suggested that lyophilization may inactivate HIV. Therefore, many surgeons who were seeking an extra measure of protection for their patients would specifically request tissues that had gone through the lyophilization process.

"This has completely changed a long-held belief," Arnoczky said, "and it's a very important contribution, as it got rid of the false sense of security people had with that process."

In their experiment,

Contact: Tom Oswald
Michigan State University

Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Research offers hope of new treatments for liver damage
3. Research suggests possible blood test for multiple sclerosis
4. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
5. 2005 Award for Basic Research in Biological Mineralization
6. 2005 Craniofacial Biology Research Award
7. 2005 Research in Dental Caries Award
8. 2005 Research in Prosthodontics and Implants Award
9. 2005 Basic Research in Periodontal Disease Award
10. 2005 Research in Oral Biology Award
11. 2005 Pulp Biology Research Award

Post Your Comments:
TAG: Research questions transplant safety procedure

(Date:10/9/2015)... ... October 09, 2015 , ... "My spouse and I rely on canes to ... something," said an inventor from Buffalo, N.Y. "This is not only frustrating but it’s ... CANE REST enables a user to keep a cane upright while it’s not in ...
(Date:10/9/2015)... ... October 09, 2015 , ... Matrix IT Medical ... specifications for TRACTUS, the world’s first sterile field scanner. , The ... to the FDA’s recent Unique Device Identifier (UDI) Final Rule, which will require ...
(Date:10/9/2015)... PA (PRWEB) , ... October 09, 2015 , ... "As ... of two inventors from Philadelphia, Pa. "They have to wear large diapers or pads. ... solutions." , They developed the TROUSAFE to absorb urine leaking from the tip of ...
(Date:10/9/2015)... ... October 09, 2015 , ... ... oldest and largest recreational dispensaries in Colorado, says the latest figures on the ... rapidly and maturing into a legitimate industry. , Last month, according to ...
(Date:10/9/2015)... ... October 09, 2015 , ... ... staffing franchise, was recognized by Cabarrus County Active Living and Parks for its ... home care company’s dedication to consistently going above and beyond the call ...
Breaking Medicine News(10 mins):
(Date:10/9/2015)... and CINCINNATI , Oct. 9, 2015 ... two Design Thinking labs with Konica Minolta Medical Imaging ... CFI to utilize Design Thinking to help healthcare providers ... future using a visual roadmap that they can customize ... --> Primary Imaging is the initial procedure, or ...
(Date:10/9/2015)... 9, 2015 RedRick Technologies, a ... solutions and reading room design guidance, is ... Radiology realize their vision of a reading ... design guidance and radiologist reading workstations that ... George Bisset , radiologist-in-chief and ...
(Date:10/9/2015)... , October 9, 2015 ... --> The report summarizes key ... overall status of the manufacturers making ... and direction for companies and individuals ... http://www.lifescienceindustryresearch.com/global-and-chinese-cochlear-implant-industry-2015-market-research-report.html . --> ...
Breaking Medicine Technology:
Cached News: