Researchers At Cedars-Sinai Medical Center Develop Method To Detect A Deadly Complication Of Pediatric Transplantation

LOS ANGELES (April 20, 1999) -- A potentially catastrophic complication of transplantation that affects 10 to 15 percent of children who receive livers or other donated organs can now be detected and treated early.

Using a method of periodic testing devised by researchers at Cedars-Sinai Medical Center, physicians can monitor the progress of young transplant recipients to rapidly detect virally infected cells. With this information, they can quickly intervene in an effort to prevent progression to posttransplant lymphoproliferative disorder (PTLD), a type of cancer with an estimated mortality rate ranging from 40 to 70 percent of the children who develop it. Most of those who survive must endure long-term complications.

"We think the way this disorder works is that patients, especially pediatric patients who have not been exposed to the Epstein-Barr virus, have the virus transmitted to them when they receive the organs of adults," said Stanley C. Jordan, M.D., director of Pediatric Nephrology and Transplant Immunology, and medical director of the Renal Transplant Program at Cedars-Sinai. "The virus is often dormant in tissues but when we suppress the immune systems of patients, the virus starts to replicate. It can affect the immune cells, primarily B cells, of the recipient. Because the patient is immune-suppressed, they can't get rid of the virus. This eventually causes a malignant transformation of the cells."

Transplant specialists, using a variety of medications, intentionally suppress the immune system of a transplant recipient to prevent rejection of a new organ. One possible consequence of this immune suppression, however, is the patient's susceptibility to other invading organisms, in this case the Epstein-Barr virus. Dr. Jordan said common symptoms of PTLD include enlarged lymph nodes, swollen liver, spleen and other organs, and gastrointestinal bleeding. Once a patient becomes symptomatic, however, the disorder may have advanced too far

Contact: Sandra Van
Cedars-Sinai Medical Center

Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:

(Date:7/19/2019)... ... July 19, 2019 , ... Juvly Aesthetics has announced ... its Director of Marketing and Sales. In his role, Okuley will be leading ... growth while furthering the company’s mission of empowering clients to look and feel ...
(Date:7/18/2019)... ... July 18, 2019 , ... The Radiology Business Management Association ... bills to protect patients from unexpected out-of-network medical bills incurred while receiving care ... Act ( H.R. 3502 ), introduced in the U.S. House by Representatives Raul ...
(Date:7/18/2019)... ... July 18, 2019 , ... NeoTract, a ... the field of urology, today announced that Garrett Matsunaga, MD, Skyline Urology in ... recognizes that Dr. Matsunaga has achieved a high level of training and experience ...
(Date:7/18/2019)... (PRWEB) , ... July 18, 2019 , ... ... Dr. Mark Deutsch is featured in Atlanta, Magazine’s list of “Top Doctors” issue. ... of cosmetic and reconstructive surgery, experience. With specialized training from MD Anderson Cancer ...
(Date:7/18/2019)... ... July 18, 2019 , ... ... being nominated 2019 Texas Monthly Super Doctor Rising Star ! Each ... who they would trust for their own medical care. The Super Doctors research ...
Breaking Medicine News(10 mins):
(Date:7/18/2019)... ... July 18, 2019 , ... NeoTract, a wholly owned ... of urology, today announced that Timothy Lesser, MD, Skyline Urology in Torrance, CA ... Dr. Lesser has achieved a high level of training and experience with the ...
(Date:7/17/2019)... ... July 17, 2019 , ... Soliant, a leading healthcare staffing ... Family Clinic Avera as its 2019 Most Beautiful Hospital in the U.S. In Soliant’s ... million - were cast for the 96 hospitals nominated. Supporters from across the country ...
(Date:7/17/2019)... (PRWEB) , ... July 17, 2019 , ... ... up with the MDA for their fourth annual national “Be Their Muscle” philanthropic ... to transform the lives of kids and adults with muscular dystrophy, ALS and ...
Breaking Medicine Technology:
Cached News: