HOME >> MEDICINE >> NEWS
Researchers Gain Insights Into Drugs Used For Manic-Depression

Many people who suffer from bipolar disorder, or manic-depression, seem to respond best to a two-drug combination treatment. Researchers at the University of Wisconsin Medical School now believe they understand why.

In the current Proceedings of the National Academy of Sciences, the scientists show that both drugs stimulate release of a chemical that triggers brain cell activity responsible for helping control the wild mood swings of bipolar disorder. Used together, the drugs may achieve a desired outcome without causing dangerous side effects.

Some three million Americans suffer from bipolar disorder, consisting of major bouts of depression followed by episodes of mania that may lead to disastrous decisions and actions. As many as one in five manic-depressives commits suicide.

Until recently, lithium was the best medication available for the disease, but because of undesirable side effects many people discontinue its use. In the past few years, an anticonvulsant drug prescribed for epilepsy, called valproate, was also found to be effective. Clinicians discovered that best results often occurred by using a combination of both drugs, especially in patients who have a form of the disease that recurs frequently.

"Lithium can be very effective but it can cause gastrointestinal and kidney problems, weight gain and grogginess, making many people want to stop using it. At higher levels the drug can be highly toxic," said UW Medical School professor of pharmacology Lowell Hokin. "Valproate does not produce the same toxicity."

Hokin and his team have studied lithium for years in an effort to understand how it could control depression and mania at the same time.

Their earlier research revealed that lithium increases release of the neurotransmitter glutamate, in turn activating a receptor, NMDA, through which calcium must travel to enter a brain cell. Activation of the NMD
'"/>

Contact: Dian Land
dianland@macc.wisc.edu
608-263-9893
University of Wisconsin-Madison
30-Apr-1997


Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... that we intend to develop to enable prevention of a major side effect ... hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader ... a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were ... 11, 2017. , The annual award competition recognizes editorial and design excellence across a ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... IRVING, Texas , Oct. 11, 2017  Caris ... science focused on fulfilling the promise of precision medicine, ... Institute has joined Caris, Precision Oncology Alliance™ (POA) as ... leading cancer centers, the St. Jude Crosson Cancer Institute ... to advance the use of tumor profiling, making cancer ...
(Date:10/10/2017)... ORANGE COUNTY, Calif. , Oct. 10, 2017  NDS received ... Mobile  — a medical-grade battery-powered display stand specifically designed for ... aims to transform technology into a clinical solution to support the ... costs. Innovative Design ... NDS ZeroWire Mobile Wireless Solution ...
(Date:10/5/2017)... , Oct. 5, 2017  In response to ... Oral and Maxillofacial Surgeons (AAOMS) released prescribing recommendations ... to be used as a first-line therapy to ... Recognizing the value ... White Paper "Opioid Prescribing: Acute and Postoperative Pain ...
Breaking Medicine Technology:
Cached News: