HOME >> MEDICINE >> NEWS
Researchers Gain Insights Into Drugs Used For Manic-Depression

Many people who suffer from bipolar disorder, or manic-depression, seem to respond best to a two-drug combination treatment. Researchers at the University of Wisconsin Medical School now believe they understand why.

In the current Proceedings of the National Academy of Sciences, the scientists show that both drugs stimulate release of a chemical that triggers brain cell activity responsible for helping control the wild mood swings of bipolar disorder. Used together, the drugs may achieve a desired outcome without causing dangerous side effects.

Some three million Americans suffer from bipolar disorder, consisting of major bouts of depression followed by episodes of mania that may lead to disastrous decisions and actions. As many as one in five manic-depressives commits suicide.

Until recently, lithium was the best medication available for the disease, but because of undesirable side effects many people discontinue its use. In the past few years, an anticonvulsant drug prescribed for epilepsy, called valproate, was also found to be effective. Clinicians discovered that best results often occurred by using a combination of both drugs, especially in patients who have a form of the disease that recurs frequently.

"Lithium can be very effective but it can cause gastrointestinal and kidney problems, weight gain and grogginess, making many people want to stop using it. At higher levels the drug can be highly toxic," said UW Medical School professor of pharmacology Lowell Hokin. "Valproate does not produce the same toxicity."

Hokin and his team have studied lithium for years in an effort to understand how it could control depression and mania at the same time.

Their earlier research revealed that lithium increases release of the neurotransmitter glutamate, in turn activating a receptor, NMDA, through which calcium must travel to enter a brain cell. Activation of the NMD
'"/>

Contact: Dian Land
dianland@macc.wisc.edu
608-263-9893
University of Wisconsin-Madison
30-Apr-1997


Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/11/2018)... ... 10, 2018 , ... TopConsumerReviews.com recently awarded a five-star rating ... This painful, persistent condition originates in the liver and is characterized by pain ... Other contributing factors may be medication side effects, overweight, and unhealthy diet. The ...
(Date:8/9/2018)... ... August 09, 2018 , ... Thousands ... have ruptured, according to cross-referenced data from The American Society of Plastic Surgeons ... rupture rates monitored by the FDA. As an MRI is recommended by FDA ...
(Date:8/9/2018)... , ... August 09, 2018 , ... ... been engaged as an Operating Partner and will have an exclusive relationship with ... role in the firm’s strategic planning, human capital sourcing, and deal origination, evaluation ...
(Date:8/7/2018)... ... August 07, 2018 , ... Today Springfield Creamery added six ... rich, cream-on-top-style yogurts are made with milk from grass-fed cows who enjoy a ... fatty acids. Nancy’s sources the milk from organic family-owned farms, all within 60 ...
(Date:8/3/2018)... ... 2018 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... the Bible meant only to be understood in this current generation. Yisrayl says he ... decode passages that he says scholars have struggled with for generations. Yisrayl says the ...
Breaking Medicine News(10 mins):
(Date:8/14/2018)... , ... August 14, 2018 , ... ... Academy, their first-ever summer harvest employment and hands-on educational program developed for students ... in a high school, junior college or university, spent a minimum of 6 ...
(Date:8/11/2018)... ... August 10, 2018 , ... Last month, Dr. Tim Herman, Lead Dentist at ... care in underserved communities surrounding its capital of Asunción. Along with a team of ... his time to help deliver care to over 550 individuals in need. , Outreaches ...
(Date:8/9/2018)... ... ... Autism is a developmental disorder affecting more than 3.5 million Americans’ ability ... 68 people have the disorder), chances are you know someone on the autism spectrum! ... autism methods of communication and tactics to interact with others. These options help set ...
Breaking Medicine Technology:
Cached News: