Researchers Identify Candidate Immunosuppressant With Fewer Side Effects

BOSTON-April 22, 1998--Researchers at Harvard Medical School and the Center for Blood Research have identified a peptide that may serve as a template for a drug that can suppress the immune response with fewer side effects than immunosuppressants currently available. In addition to benefiting people who receive organ transplants, a drug based on this agent potentially could be used to treat chronic conditions caused by excessive or inappropriate immune responses, such as asthma, inflammation, allergies, and rheumatoid arthritis. Their findings are published in the April 24 Molecular Cell.

The two main immunosuppressant drugs used today, cyclosporin A and FK506, prevent the rejection of foreign organs or bone marrow by disrupting the signaling pathway that activates T cells. But both drugs can cause kidney and nervous system damage, making them unsuitable for wider clinical application. The newly identified peptide prevents a single, specific step in the immune system's signaling pathway, so researchers anticipate that it will not cause serious side effects.

Anjana Rao, professor of pathology, Patrick Hogan, investigator, and their colleagues at Harvard Medical School and the Center for Blood Research made a peptide that binds to calcineurin, a key molecule in the pathway that transmits signals from the T cell receptor to the nucleus. The key difference between how the peptide and the drugs cyclosporin A and FK506 work is the region on calcineurin where each of these agents bind. Cyclosporin A and FK506 block the active site of calcineurin and prevent it from acting on any other molecules within the cell. The peptide, on the other hand, only blocks specific binding between calcineurin and NFAT (nuclear factor of activated T cells). Other calcineurin functions are unimpeded.

With the peptide in place, calcineurin is unable to bind to the transcription factor NFAT and the signaling pa

Contact: Peta Gillyatt
Harvard Medical School

Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:

(Date:9/1/2020)... ... September 01, 2020 , ... KitoTech Medical, a Seattle-based medical ... which will be used to accelerate the commercialization of its microMend® family of ... will continue to expand its customer base of healthcare systems as well as ...
(Date:9/1/2020)... MESA, Calif. (PRWEB) , ... September 01, 2020 , ... ... the “safe side”, the Cohn Health Institute has taken this time to ... In celebration of its 30th Anniversary, the Cohn Health Institute will be relaunching its ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... (AHN), are joining biomedical engineers from Carnegie Mellon University (CMU) to develop a ... patients who have undergone open heart surgery. , The AGH/CMU team was recently ...
(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... Want to ... 1, Cerebral Palsy Alliance Research Foundation (CPARF) is thrilled to launch its fourth annual ... research. A fully virtual challenge, STEPtember meets everyone wherever they are at this moment ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... ... Austin Oral Surgery – an oral and maxillofacial surgery practice with 11 ... has joined the practice. An accomplished oral and maxillofacial surgeon, Dr. Szalay’s primary responsibility ... open this fall. The new office is slated for 1601 E. Pflugerville Parkway, Building ...
(Date:8/27/2020)... ... August 27, 2020 , ... The GHT Companies , a leading developer ... Feeding San Diego with a press conference at its manufacturing facility in ... check of $5,000.00+ representing an overall donation result exceeding $30,000 to Feeding San Diego, ...
(Date:8/26/2020)... (PRWEB) , ... August 26, ... ... Holdings company today announced that it has entered into definitive agreement to ... CME/CE, primarily focused on pharmacists and pharmacy technicians. , CEA represents ...
Breaking Medicine Technology:
Cached News: