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Researchers at Cincinnati Children's link a strain of E. coli to diarrhea in children

SAN FRANCISCO Researchers at Cincinnati Children's Hospital Medical Center have determined that a bacterium called enteroaggregative E. coli, is responsible for 10 percent of cases of diarrhea in children. The discovery could one day lead to new treatment for children who suffer from diarrhea.

A number of strains of E. coli have been linked to diarrhea, but this is the first time that enteroaggregative E. coli has been linked to the illness in the United States. One of the most important aspects of the new study was the use of genetic technology to look for the presence of specific patterns of E. coli DNA. This in turn led to the identification of genes associated with diarrhea.

Other tests that look for E. coli infections are based on the use of tissue culture cells, which is not always a reliable way to identify specific strains of E. coli, according to Mitchell B. Cohen, M.D., a professor of pediatrics at Cincinnati Children's who led the research team.

Once confirmed in follow-up studies, the new research could eventually lead to the availability of testing for enteroaggregative E. coli, he said.

"The lack of having a test is, in part, why medical professionals have never really before linked enteroaggregative E. coli to diarrhea in children in the United States," Dr. Cohen said. "The identification of a different etiology allows us to focus on the question of whether diarrhea caused by viruses or bacteria should be treated differently. The strength of the study is that we can now look at these children and decide if we should develop therapies to target bacterial or viral infections."

Mary A. Staat, M.D, M.P.H., an associate professor of infectious diseases and study co-author, will present the results of the study on May 2 in San Francisco at the annual meeting of the Pediatric Academic Societies.

E. coli is a foodborne pathogen and a bacterium that normally resides in the lower intestine. There are hundreds o
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Contact: Amy Reyes
amy.reyes@cchmc.org
513-636-9684
Cincinnati Children's Hospital Medical Center
2-May-2004


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