Researchers closer to delivering new insulin pill for diabetics

WEST LAFAYETTE, Ind. Chemical engineers are getting closer to developing a method for taking insulin and other medications orally instead of by injection, research that would benefit hundreds of thousands of diabetics in the United States alone.

Purdue University researchers, in findings to be discussed Aug. 26 during a national meeting of the American Chemical Society, have demonstrated that the method works in a chemical environment that mimics the stomach and upper small intestine.

The method might be used to treat insulin-dependent diabetes and other conditions for which medicines, such as insulin, currently cannot be administered orally because they are broken down in the acidic environment of the stomach.

To get around this complication, the engineers have made microscopic particles for drug delivery about a millionth of a meter in diameter, or roughly one-hundredth the width of a human hair. The particles protect medicines from the harsh environment of the stomach until they can be released in the intestines and absorbed into the blood.

In the most recent lab experiments, and in animal research, when the particles enter the less-acidic environment of the upper small intestine they expand and use chemical tethers to latch onto "mucosal" areas and cells that line the intestine.

The tethers serve two roles: They help prevent stomach enzymes from breaking down the particles. And once the particles enter the intestines, the tethers keep the particles anchored long enough for the medication to be released into the upper small intestine, where the medication is absorbed by capillaries into the blood.

"If we don't have these 'anchors' to stick in the upper small intestine and hold the particles for a little while, they will pass through and the medication will never release in the upper small intestine," said Nicholas A. Peppas, Purdue's Showalter Distinguished Professor of Chemical and Biomedical Engineering. <

Contact: Emil Venere
Purdue University

Page: 1 2 3

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:

(Date:7/10/2020)... ... 10, 2020 , ... Inversion therapy is defined by Healthline.com, as a technique ... back pain.” Ergo, the theory is that if the body’s point of gravity is ... spine using the head and upper body as the "weights" needed to stretch the ...
(Date:7/10/2020)... ... July 09, 2020 , ... CellTrak, the leading ... announces that Ohio Department of Medicaid has awarded CellTrak Phase 2 EVV certification ... Ohio already rely on CellTrak for EVV – both as a point-of-care solution ...
(Date:7/10/2020)... ... 10, 2020 , ... NeoTract, a wholly owned subsidiary of ... today announced that Carl Meyer, M.D., The Iowa Clinic in West Des Moines, ... that Dr. Meyer has achieved a high level of training and experience with ...
(Date:7/7/2020)... ... ... Mediaplanet recently launched an awareness initiative to inspire more people to pursue ... the spotlight and, as a result, the Bureau of Labor Statistics predicts job growth ... University — which offers a Master’s in Public Health degree program both online ...
(Date:7/7/2020)... ... July 07, 2020 , ... The Germ-Fogger™ disinfecting ... to efficiently sanitize large surfaces is now available in Mexico and Latin America. ... in that region. , In this era of worldwide pandemic, the ability to ...
Breaking Medicine News(10 mins):
(Date:7/7/2020)... ... 2020 , ... With projects ranging from nourishing people in ... who received the latest ISA Foundation grants will make a significant ... grants totaling $838,527 to the U.S.-based 501(c)(3) nonprofit organizations. , Operated by ...
(Date:7/4/2020)... CANCÚN QUINTANA ROO, México (PRWEB) , ... July ... ... beaches and hotels of the Riviera Maya began to welcome visitors at approved ... which include careful cleaning and sanitizing, among other preventive actions. , The most ...
(Date:7/2/2020)... ... ... Exercise.com, the fitness industry’s leading tech company specializing in all-in-one business software for ... during the months of May and June. This announcement highlights the growing demand for ... giants like 24 Hour Fitness and Gold’s Gym are unsafe ...
Breaking Medicine Technology:
Cached News: