HOME >> MEDICINE >> NEWS
Researchers discover alcohol-sensitive membrane channel

Site found while examining ethanol's effect on potassium channels

A study reported in the December issue of Nature Neuroscience (Volume 2, Number 12, pages 1084-1090) identifies a new cell membrane channel where ethanol, the alcohol found in intoxicating beverages, may act. Neurobiologists from the Waggoner Center for Alcohol and Addiction Research and Section on Neurobiology, and the Department of Pharmacology and Toxicology, College of Pharmacy, University of Texas (UT) at Austin discovered actions of alcohol while studying a subtype of potassium channels, a diverse family of ion channels that perform many central nervous system functions. Identification of the alcohol-sensitive channel has significant implications because of its key role in brain function.

"Molecular analysis of this cell memberane channel ultimately will increase our knowledge of how alcohol affects the brain and, thereby, the way a person functions," said Enoch Gordis, M.D., Director, National Institute on Alcohol Abuse and Alcoholism (NIAAA), a component of the National Institutes of Health.

Joanne M. Lewohl, Ph.D., and her associates identified the effect of ethanol on the G-protein-coupled inwardly rectifying potassium channel (GIRK). GIRKs are widely distributed in the brain and play a major role in regulating inhibitory responses in the central nervous system. They act by regulating neuron-to-neuron communication and the rate of this information transfer.

Whereas most potassium channels are either unaffected or inhibited by ethanol and other alcohols, GIRK channels were shown to be sensitive to ethanol at a concentration below the legal level for intoxication (10mM), the researchers found. This high sensitivity to relatively minor changes may influence substantially the capability of neurons to communicate. The researchers conclude that ethanol enhances or exaggerates the effect of normal neurotransmitter action, producing profound physiological effe
'"/>

Contact: Ann Bradley
abradley@willco.niaaa.nih.gov
301-443-3860
NIH/National Institute on Alcohol Abuse and Alcoholism
21-Nov-1999


Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... Little Rock, AR (PRWEB) , ... October 13, ... ... owned firm with locations throughout Arkansas that offers insurance and financial preparation services, ... to benefit the Rock City Rescue organization. , Rock City Rescue is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading ... Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly ... CBD form that can be easily incorporated into liquid products, while reducing costs to ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  True Health, a ... amplified its effort during National Breast Cancer Awareness ... cancer risks. ... Oncology calculated that more than 10 million American ... mutations in BRCA1 or BRCA2 and have not had ...
(Date:10/10/2017)... COUNTY, Calif. , Oct. 10, 2017  NDS received FDA ... Mobile  — a medical-grade battery-powered display stand specifically designed for endoscopy ... to transform technology into a clinical solution to support the improvement ... Innovative Design ... ZeroWire Mobile Wireless Solution ...
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on Provistaco.com ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
Breaking Medicine Technology:
Cached News: