HOME >> MEDICINE >> NEWS
Researchers discover link between insulin and Alzheimer's

Providence, RI Researchers at Rhode Island Hospital and Brown Medical School have discovered that insulin and its related proteins are produced in the brain, and that reduced levels of both are linked to Alzheimer's disease. The findings are reported in the March issue of the Journal of Alzheimer's Disease (http://www.j-alz.com), published by IOS Press.

"What we found is that insulin is not just produced in the pancreas, but also in the brain. And we discovered that insulin and its growth factors, which are necessary for the survival of brain cells, contribute to the progression of Alzheimer's," says senior author Suzanne M. de la Monte, a neuropathologist at Rhode Island Hospital and a professor of pathology at Brown Medical School. "This raises the possibility of a Type 3 diabetes."

It has previously been known that insulin resistance, a characteristic of diabetes, is tied to neurodegeneration. While scientists have suspected a link between diabetes and Alzheimer's disease, this is the first study to provide evidence of that connection.

By studying a gene abnormality in rats that blocks insulin signaling in the brain, researchers found that insulin and IGF I and II are all expressed in neurons in several regions in the brain.

Additionally, researchers determined that a drop in insulin production in the brain contributes to the degeneration of brain cells, an early symptom of Alzheimer's. "These abnormalities do not correspond to Type 1 or Type 2 diabetes, but reflect a different and more complex disease process that originates in the CNS (central nervous system)," the paper states.

By looking at postmortem brain tissue from people diagnosed with Alzheimer's disease, researchers discovered that growth factors are not produced at normal levels in the hippocampus the part of the brain responsible for memory. The absence of these growth factors, in turn, causes cells in other parts of the b
'"/>

Contact: Nicole Gustin
ngustin@lifespan.org
401-444-7299
Lifespan
7-Mar-2005


Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers model brains electrical storm during a seizure
5. Researchers track programs success in curbing aggressive behavior
6. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
7. Researchers offer emergency workers a lifeline
8. Researchers discover genetic variant that may explain why women develop M.S. more than men
9. Researchers map the sexual network of an entire high school
10. Researchers hope monkeys can provide new insights into depression
11. Researchers identify the link between heart failure and weight loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/13/2019)... , ... July 12, 2019 , ... The American Med ... This report is designed to help medical aesthetic and medical spa professionals understand the ... providers across the industry. , “It’s been two years since AmSpa released the 2017 ...
(Date:7/12/2019)... ... July 12, 2019 , ... Rebecca Baxt, M.D., F.A.A.D. and Saida Baxt, M.D., ... 2019. Located in Paramus, BAXT CosMedical is a renowned facility that believes in honest ... for the past 45 years. , NJ Top Docs, Dr. Rebecca Baxt and Dr. ...
(Date:7/11/2019)... (PRWEB) , ... July 11, 2019 , ... ... new knowledge tools and educational resources with a range of features to further ... across the global pharmaceutical industry in manufacturing quality medicines for patients worldwide. The ...
(Date:7/10/2019)... , ... July 10, 2019 , ... Foggiare --the ... for this unique and effective beauty and wellness technology. Developed by Sauna Italia ... system that is already a proven success in over 180 locations in Europe and ...
(Date:7/10/2019)... (PRWEB) , ... July 10, 2019 , ... HMP, a ... an official partner of the Oncology Clinical Pathways Congress, taking place October 11-13, 2019 ... Journal of Clinical Pathways and focuses on the expansion of clinical pathways as a ...
Breaking Medicine News(10 mins):
(Date:7/11/2019)... ... July 11, 2019 , ... Healthy Hemp ... in line with TSA guidelines for domestic airline flights. , Previously, all ... changed its guidelines to allow some forms of cannabinoid (CBD) oil and ...
(Date:7/11/2019)... ... July 11, 2019 , ... Nobility RCM, ... partnership with Palmer College of Chiropractic, the first and largest chiropractic college in ... specially selected to handle its billing and revenue cycle for the institution’s clinical ...
(Date:7/10/2019)... ... July 10, 2019 , ... ... clinical study from Ohio State University Wexner Medical Center for PrimaVie®, its ... acid, and micro minerals. Natreon is committed to continued scientific investment and ...
Breaking Medicine Technology:
Cached News: