HOME >> MEDICINE >> NEWS
Researchers discover link between insulin and Alzheimer's

Providence, RI Researchers at Rhode Island Hospital and Brown Medical School have discovered that insulin and its related proteins are produced in the brain, and that reduced levels of both are linked to Alzheimer's disease. The findings are reported in the March issue of the Journal of Alzheimer's Disease (http://www.j-alz.com), published by IOS Press.

"What we found is that insulin is not just produced in the pancreas, but also in the brain. And we discovered that insulin and its growth factors, which are necessary for the survival of brain cells, contribute to the progression of Alzheimer's," says senior author Suzanne M. de la Monte, a neuropathologist at Rhode Island Hospital and a professor of pathology at Brown Medical School. "This raises the possibility of a Type 3 diabetes."

It has previously been known that insulin resistance, a characteristic of diabetes, is tied to neurodegeneration. While scientists have suspected a link between diabetes and Alzheimer's disease, this is the first study to provide evidence of that connection.

By studying a gene abnormality in rats that blocks insulin signaling in the brain, researchers found that insulin and IGF I and II are all expressed in neurons in several regions in the brain.

Additionally, researchers determined that a drop in insulin production in the brain contributes to the degeneration of brain cells, an early symptom of Alzheimer's. "These abnormalities do not correspond to Type 1 or Type 2 diabetes, but reflect a different and more complex disease process that originates in the CNS (central nervous system)," the paper states.

By looking at postmortem brain tissue from people diagnosed with Alzheimer's disease, researchers discovered that growth factors are not produced at normal levels in the hippocampus the part of the brain responsible for memory. The absence of these growth factors, in turn, causes cells in other parts of the b
'"/>

Contact: Nicole Gustin
ngustin@lifespan.org
401-444-7299
Lifespan
7-Mar-2005


Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers model brains electrical storm during a seizure
5. Researchers track programs success in curbing aggressive behavior
6. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
7. Researchers offer emergency workers a lifeline
8. Researchers discover genetic variant that may explain why women develop M.S. more than men
9. Researchers map the sexual network of an entire high school
10. Researchers hope monkeys can provide new insights into depression
11. Researchers identify the link between heart failure and weight loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance Group, a ... Miami, and Raleigh regions, is organizing an extended charity drive to benefit the ... chromosome abnormality. , After struggling since birth with several health challenges, T.J. was ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's ... President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. ... 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Lori R. ... a member of ElderCounsel, a national organization of elder law and special needs planning ... laws and rules. It also provides a forum to network with elder law attorneys ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the ... analysis system called the HORIZON at MIBio 2017 in ... subvisible and visible particulate matter in biopharmaceutical samples with unprecedented speed ... of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/27/2017)... CAESAREA, Israel and NEW YORK , Sept. ... company with mobile health and big data solutions, today announced that its ... today. Please check your local TV listings for when The Dr. Oz ... ... ninth season this month. ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical ... device is now successfully helping those with the widespread ... Fibromyalgia diagnosed Amanda in Essex, England ... and washing my hair, experiencing no sleep at all, ... painful spasm… I cannot recommend [the AVACEN 100] enough, ...
Breaking Medicine Technology:
Cached News: