HOME >> MEDICINE >> NEWS
Researchers discover link between insulin and Alzheimer's

Providence, RI Researchers at Rhode Island Hospital and Brown Medical School have discovered that insulin and its related proteins are produced in the brain, and that reduced levels of both are linked to Alzheimer's disease. The findings are reported in the March issue of the Journal of Alzheimer's Disease (http://www.j-alz.com), published by IOS Press.

"What we found is that insulin is not just produced in the pancreas, but also in the brain. And we discovered that insulin and its growth factors, which are necessary for the survival of brain cells, contribute to the progression of Alzheimer's," says senior author Suzanne M. de la Monte, a neuropathologist at Rhode Island Hospital and a professor of pathology at Brown Medical School. "This raises the possibility of a Type 3 diabetes."

It has previously been known that insulin resistance, a characteristic of diabetes, is tied to neurodegeneration. While scientists have suspected a link between diabetes and Alzheimer's disease, this is the first study to provide evidence of that connection.

By studying a gene abnormality in rats that blocks insulin signaling in the brain, researchers found that insulin and IGF I and II are all expressed in neurons in several regions in the brain.

Additionally, researchers determined that a drop in insulin production in the brain contributes to the degeneration of brain cells, an early symptom of Alzheimer's. "These abnormalities do not correspond to Type 1 or Type 2 diabetes, but reflect a different and more complex disease process that originates in the CNS (central nervous system)," the paper states.

By looking at postmortem brain tissue from people diagnosed with Alzheimer's disease, researchers discovered that growth factors are not produced at normal levels in the hippocampus the part of the brain responsible for memory. The absence of these growth factors, in turn, causes cells in other parts of the b
'"/>

Contact: Nicole Gustin
ngustin@lifespan.org
401-444-7299
Lifespan
7-Mar-2005


Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers model brains electrical storm during a seizure
5. Researchers track programs success in curbing aggressive behavior
6. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
7. Researchers offer emergency workers a lifeline
8. Researchers discover genetic variant that may explain why women develop M.S. more than men
9. Researchers map the sexual network of an entire high school
10. Researchers hope monkeys can provide new insights into depression
11. Researchers identify the link between heart failure and weight loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/20/2017)... ... August 20, 2017 , ... Are you an adult with gluten intolerance ... you may be interested in participating in a research study that focuses on family ... understand more about the relational aspects of adults who have gluten sensitivities who cohabitate ...
(Date:8/19/2017)... York (PRWEB) , ... August 19, 2017 , ... ... has announced that it is the first organization with pending recognition status from ... Diabetes Prevention Program (“DPP”) via group telehealth classes and live video conferencing. ...
(Date:8/19/2017)... Fla. (PRWEB) , ... August 19, 2017 , ... ... Taufiq Ahmed, M.D., has joined its Orlando location as an interventional pain management ... anesthesiology, a focus on the treatment of migraine headaches, and significant experience in ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... specialized asset-light logistics provider of complex transport solutions for mission-critical and non-discretionary ... Unitrans International Corporation, a division of Roadrunner Transportation Systems, Inc. (NYSE: RRTS). ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Dawn Johnson Insurance ... a new charity drive to generate community support for efforts to educate the local ... and treatments for all types of cancer. , Each day in America, roughly ...
Breaking Medicine News(10 mins):
(Date:8/14/2017)... N.J. and PETACH TIKVAH, Israel ... Inc. (NASDAQ: BCLI), a leading developer of adult stem ... the second quarter ending June 30, 2017. ... stages of preparing for our pivotal Phase 3 trial ... Chaim Lebovits , President and Chief Executive Officer of ...
(Date:8/8/2017)... Second-quarter 2017 revenues of $876 ... from continuing operations Second-quarter ... $110 million Second-quarter 2017 ... Second-quarter 2017 adjusted diluted ... percent to $0.93 Second-quarter ...
(Date:8/7/2017)... 7, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), the nation,s ... ended June 30, 2017.  All comparisons, unless otherwise noted, are ... Second Quarter 2017 Highlights include: ... million, an increase of 3.5% Total prescriptions ... margin of 7.5% versus 7.6% Gross ...
Breaking Medicine Technology:
Cached News: