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Researchers discover link between insulin and Alzheimer's

rain to die. Reserachers found that insulin and IGF I were significantly reduced in the frontal cortex, hippocampus and hypothalamus all areas that are affected by the progression of Alzheimer's. Conversely, in the cerebellum, which is generally not affected by Alzheimer's, scientists did not see the same drop in insulin and IGF I.

"Now that scientists have pinpointed insulin and its growth factors as contributors to Alzheimer's, this opens the way for targeted treatment to the brain and changes the way we view Alzheimer's disease," de la Monte says.

In an accompanying review article, de la Monte and accompanying author Jack Wands, MD, of Rhode Island Hospital and Brown Medical School, write that "there is a genuine need for thorough and comprehensive study of the neuropathological changes associated with diabetes mellitus, in the presence or absence of superimposed Alzheimer's Disease or vascular dementia."


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Contact: Nicole Gustin
ngustin@lifespan.org
401-444-7299
Lifespan
7-Mar-2005


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