HOME >> MEDICINE >> NEWS
Researchers find better way to predict childhood brain tumor outcomes

(Boston, MA) A distinctive "signature" of genes turned on and off greatly improves predictions of who has the best chance of survival of the most common type of childhood malignant brain tumor, according to a new study by researchers at Childrens Hospital Boston and their colleagues. If verified by other studies over the next several years, the gene expression profile may help children survive the malignant brain tumor with fewer serious side effects. The study also shows that medulloblastoma has key molecular differences from other brain tumors, which eventually may help researchers find more targeted treatment. The study is published in the Jan. 24 issue of the weekly journal Nature.

"Over the past 20 years, survival from medulloblastomas has dramatically improved," says pediatric neurologist Scott Pomeroy, first author of the paper. "In modern clinical trials, more than 80 percent of good-risk patients survive. Nearly 100 percent of the survivors, however, have learning disabilities, most have hearing loss and cataracts, and the majority are unable to live independent of their families as adults. A major goal of current treatment trials, then, is to reduce the level of radiation to lessen toxicity without compromising survival in good-risk patients."

Now, risk is defined by clinical criteria, such as the presence of metastases on MRI scanning, excessive tumor remaining in the brain after surgery, and examination of tumor tissue under a microscope. "Our predictor is much more accurate than these clinical criteria," says Pomeroy, also an associate professor at Harvard Medical School.

About 2,000 children a year are diagnosed with medulloblastoma, with diagnosis verified at the time of surgery. For this study, researchers examined gene expression patterns from 99 patient tumor samples of three different types of brain tumors. In addition to distinguishing tumor types from each other, the study found strong expression of a signaling protei
'"/>

Contact: Bess Andrews
elizabeth.andrews@TCH.Harvard.edu
617-355-6420
Harvard Medical School
24-Jan-2002


Page: 1 2 3

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... , ... Ellevate Network, the leading network for professional women, brought together some ... at their inaugural Summit in New York City in June. The event was livestreamed ... over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of ... Philippines. “The Journey: From the Mountains to the Mission Field” is the creation of ... taught all ages and currently teaches a class of ladies at her church, which ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has ... today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula ... the highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. ... recently contributed a medical article to the newly revamped Cosmetic Town journal ... spotlights the hair transplant procedure known as Follicular Unit Extraction (FUE). ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... nation's first interactive health literacy software tool, and the Cancer Patient Education Network ... cancer patient education, today announce a new strategic alliance. , As CPEN’s ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... Sept. 25, 2017  EpiVax, Inc., a leader ... and immune-engineering today announced the launch of EpiVax ... of personalized therapeutic cancer vaccines. EpiVax has provided ... access to enabling technologies to the new precision ... lead EpiVax Oncology as Chief Executive Officer. Gad ...
(Date:9/19/2017)... Sept. 19, 2017   ZirMed Inc ., a recognized ... announced that it has been ranked #1 by its users ... Rankings 2017 User Survey. ZirMed was recognized as the ... hospitals and medical centers over 200 beds and holds one ... technology user survey history. ...
(Date:9/12/2017)... Sept. 12, 2017  Consumer reviews on the independent review site ... the number one company for hearing aids, ranking it higher than ... brands. ... #1 by Consumers For Hearing Aids ... Hearing is an online store that provides high performance, state-of-the-art, German-engineered ...
Breaking Medicine Technology:
Cached News: