Researchers find better way to predict childhood brain tumor outcomes

(Boston, MA) A distinctive "signature" of genes turned on and off greatly improves predictions of who has the best chance of survival of the most common type of childhood malignant brain tumor, according to a new study by researchers at Childrens Hospital Boston and their colleagues. If verified by other studies over the next several years, the gene expression profile may help children survive the malignant brain tumor with fewer serious side effects. The study also shows that medulloblastoma has key molecular differences from other brain tumors, which eventually may help researchers find more targeted treatment. The study is published in the Jan. 24 issue of the weekly journal Nature.

"Over the past 20 years, survival from medulloblastomas has dramatically improved," says pediatric neurologist Scott Pomeroy, first author of the paper. "In modern clinical trials, more than 80 percent of good-risk patients survive. Nearly 100 percent of the survivors, however, have learning disabilities, most have hearing loss and cataracts, and the majority are unable to live independent of their families as adults. A major goal of current treatment trials, then, is to reduce the level of radiation to lessen toxicity without compromising survival in good-risk patients."

Now, risk is defined by clinical criteria, such as the presence of metastases on MRI scanning, excessive tumor remaining in the brain after surgery, and examination of tumor tissue under a microscope. "Our predictor is much more accurate than these clinical criteria," says Pomeroy, also an associate professor at Harvard Medical School.

About 2,000 children a year are diagnosed with medulloblastoma, with diagnosis verified at the time of surgery. For this study, researchers examined gene expression patterns from 99 patient tumor samples of three different types of brain tumors. In addition to distinguishing tumor types from each other, the study found strong expression of a signaling protei

Contact: Bess Andrews
Harvard Medical School

Page: 1 2 3

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:

(Date:10/9/2015)... ... October 09, 2015 , ... The American Osteopathic Foundation (AOF) ... Medical Education J. Michael Finley, DO, as the recipient of the 2015 W. ... impact on graduate medical education opportunities for osteopathic residents, and his dedication to ...
(Date:10/9/2015)... ... 09, 2015 , ... "My spouse and I rely on canes to walk, ... said an inventor from Buffalo, N.Y. "This is not only frustrating but it’s unsanitary. ... REST enables a user to keep a cane upright while it’s not in use. ...
(Date:10/9/2015)... (PRWEB) , ... October 09, 2015 , ... ... company, has announced the final product specifications for TRACTUS, the world’s first sterile ... in the United States in response to the FDA’s recent Unique Device Identifier ...
(Date:10/9/2015)... (PRWEB) , ... October 09, 2015 , ... "As a ... two inventors from Philadelphia, Pa. "They have to wear large diapers or pads. We ... , They developed the TROUSAFE to absorb urine leaking from the tip of the ...
(Date:10/9/2015)... (PRWEB) , ... October 09, 2015 , ... ... one of the oldest and largest recreational dispensaries in Colorado, says the latest ... business is growing rapidly and maturing into a legitimate industry. , Last ...
Breaking Medicine News(10 mins):
(Date:10/9/2015)... Maryland , October 9, 2015 ... Inc. (OTCQB: CNBX) has announced its execution of an Intellectual ... & Liabilities Agreement with Cannabics, Inc. a Delaware Corporation, related ... company. --> --> ... restructuring of the Company, whereby the Research and Development ...
(Date:10/9/2015)... ClinicalKey Nursing debuts at ANCC National ... Elsevier , a world-leading provider of scientific, technical and ... Nursing , a new clinical reference platform that will provide ... nursing professionals. Attendees of the ANCC National Magnet Conference ... have the opportunity to demo ClinicalKey Nursing at booth #1309. ...
(Date:10/9/2015)... 2015 Eli Lilly and Company (NYSE: LLY ... approximately 50 new jobs to its research and development presence ... York, New York . --> ... will include a translational immuno-oncology hub and a Lilly "portal," ... access to cutting-edge drug discovery capabilities, including chemistry and lead ...
Breaking Medicine Technology:
Cached News: