at the time of diagnosis, before patients receive treatment," says pediatric oncologist Todd Golub, senior author of this paper. "It is important not only for medulloblastoma, but because it suggests that such signatures are likely to be detectable for other cancers as well." Golub is an assistant professor of Pediatrics at Harvard Medical School and holds joint appointments at Childrens Hospital Boston, Dana-Farber Cancer Institute and the Whitehead Institute.

"The clinical implementation of genomics-based outcome predictors must await confirmation in independent data sets, and the models may need to be modified as treatment regimens evolve," says Pomeroy. "Nevertheless, this work illustrates how genomic technologies have the potential to advance treatment planning beyond the empiric, toward a more molecularly defined, individualized approach to medicine."

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Contact: Bess Andrews
elizabeth.andrews@TCH.Harvard.edu
617-355-6420
Harvard Medical School
24-Jan-2002

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