HOME >> MEDICINE >> NEWS
Researchers gain insight into function of memory enhancing drugs

Researchers at the National Institute of Child Health and Human Development (NICHD) and the Howard Hughes Medical Institute have come one step closer to understanding how experimental, memory-enhancing drugs affect the brain on a molecular level. The researchers published their results in the May 16 issue of Nature.

The finding provides an important insight into the mechanisms that regulate the sensitivity of brain cells to neurotransmitters, the chemical messengers that the cells use to communicate with one another.

"Learning how neurons respond to neurotransmitters is important not only to understanding basic brain functioning, but also may one day lead to new insight into a variety of new therapies," said Duane Alexander, Director of the NICHD.

Like a key fits into a lock, neurotransmitters fit into specific sites, or receptors, studding the surface of brain cells. In an elaborate relay system, a cell that is excited by one neurotransmitter will, in turn, release neurotransmitters of its own. These affect still other cells, which, in turn, release more neurotransmitters, and so on. In this way, messages are transmitted throughout the brain's various mental circuits.

The researchers studied one of the glutamate receptors, found throughout the brain and involved in numerous learning and memory processes. Whether in the brain or in laboratory cultures, many receptors show reduced activity when exposed to higher-than-normal amounts of a neurotransmitter, a process called desensitization. Essentially, the cells become less sensitive to the effects of neurotransmitters.

According to an NICHD author of the paper, Mark Mayer, head of the Laboratory of Cellular and Molecular Neurophysiology, the researchers biochemically isolated one part of the glutamate receptor and determined its structure at the atomic level. They then designed altered, or mutant, receptors and determined their atomic structures as well. By observing ho
'"/>

Contact: Bob Bock
rb96a@nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
15-May-2002


Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers gain insight into function memory enhancing drugs

(Date:5/29/2015)... Abington Hospital – Jefferson Health ... hospitals in the nation to join the ... and work toward achieving the Baby-Friendly USA© designation. ... on maternity care practices leading to Baby-Friendly designation. ... Prevention, EMPower is aimed at increasing breastfeeding rates ...
(Date:5/29/2015)... On May 21, 2015, Elle Magazine in article titled ... Botox ?” reported on the four most commonly searched beauty ... to determine these results and then sought expert help to ... example, is how to keep neck skin tight . ... the appropriate age to start receiving Botox injections . ...
(Date:5/29/2015)... The Healthcare Delivery Institute at HORNE ... Training Program (ATP) in Healthcare Delivery Improvement. The ... health care organization ranging from clinicians to CFOs, ... quality improvement in the health care environment. The ... internationally recognized Advanced Training Program at Intermountain Healthcare. ...
(Date:5/29/2015)... 29, 2015 The print component of ... circulation of approximately 250,000 and an estimated readership of ... vast social media strategy, and across a network of ... digital version of the campaign, click here. ... publication. Inside, the actress, model and producer details her ...
(Date:5/29/2015)... Shaila Jiwa, a physiotherapist from Burnaby ... stated in a new announcement that patients of urinary ... commonly seen as a tabooed topic to talk about ... like Shaila Jiwa try to encourage people to come ... is a condition that can be classified under two ...
Breaking Medicine News(10 mins):Health News:Abington Hospital Selected to Join Baby-Friendly Hospital Initiative 2Health News:Botox, Wrinkles and Double Chins: The Most-Asked Beauty Problems According to Google 2Health News:HORNE LLP’s Healthcare Delivery Institute Graduates Class from the Advanced Training Program 2Health News:Patients of Urinary Incontinence Should Not "Hide And Suffer," States Physiotherapist from Burnaby Physiotherapy Clinic 2
(Date:5/29/2015)... 29, 2015  The annual customer satisfaction survey of ... EMR as #1 across all specialties. Every year, ... conducts a poll of EHR users and publishes an ... Praxis EMR topped 348 other systems, ... based criteria used by Black Book. In addition to ...
(Date:5/29/2015)... 2015 /CNW/ - Covalon Technologies Ltd. (the "Company" or ... is delighted to announce its financial results for ... includes revenue for three months of $2,180,276 and ... advanced wound care product sales for the three ... to $1,742,672 compared to $1,400,065 for the same ...
(Date:5/29/2015)... 2015 Amgen (NASDAQ: AMGN ) ... 3, global, randomized, placebo-controlled trials evaluating AMG 416, ... hyperparathyroidism (SHPT) in patients with chronic kidney disease ... endpoint, demonstrating that a greater proportion of patients ... than 30 percent reduction in parathyroid hormone (PTH) ...
Breaking Medicine Technology:Praxis EMR Ranks #1 for Physician Satisfaction in Black Book's 2015 Survey of Solo and Small Practices 2Covalon Announces Strong Second Quarter Results 2Covalon Announces Strong Second Quarter Results 3Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 2Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 3Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 4Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 5Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 6Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 7
Cached News: