HOME >> MEDICINE >> NEWS
Researchers gain insight into function of memory enhancing drugs

Researchers at the National Institute of Child Health and Human Development (NICHD) and the Howard Hughes Medical Institute have come one step closer to understanding how experimental, memory-enhancing drugs affect the brain on a molecular level. The researchers published their results in the May 16 issue of Nature.

The finding provides an important insight into the mechanisms that regulate the sensitivity of brain cells to neurotransmitters, the chemical messengers that the cells use to communicate with one another.

"Learning how neurons respond to neurotransmitters is important not only to understanding basic brain functioning, but also may one day lead to new insight into a variety of new therapies," said Duane Alexander, Director of the NICHD.

Like a key fits into a lock, neurotransmitters fit into specific sites, or receptors, studding the surface of brain cells. In an elaborate relay system, a cell that is excited by one neurotransmitter will, in turn, release neurotransmitters of its own. These affect still other cells, which, in turn, release more neurotransmitters, and so on. In this way, messages are transmitted throughout the brain's various mental circuits.

The researchers studied one of the glutamate receptors, found throughout the brain and involved in numerous learning and memory processes. Whether in the brain or in laboratory cultures, many receptors show reduced activity when exposed to higher-than-normal amounts of a neurotransmitter, a process called desensitization. Essentially, the cells become less sensitive to the effects of neurotransmitters.

According to an NICHD author of the paper, Mark Mayer, head of the Laboratory of Cellular and Molecular Neurophysiology, the researchers biochemically isolated one part of the glutamate receptor and determined its structure at the atomic level. They then designed altered, or mutant, receptors and determined their atomic structures as well. By observing ho
'"/>

Contact: Bob Bock
rb96a@nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
15-May-2002


Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers gain insight into function memory enhancing drugs

(Date:8/28/2015)... ... August 28, 2015 , ... Altima Technologies, Inc., the maker ... data center assets and audio-video devices, recently released Visio Stencils for the following ... ProLiant Gen9, EMC VNX Series , Super Micro Computer SuperStorage, Hitachi Data Systems ...
(Date:8/28/2015)... ... ... Dr. Gregory K. Toumayan, D.C., Q.M.E., is now treating patients with back ... hip pain, neck pain, stiffness, muscle spasms, and numbness. , Dr. Toumayan received ... went on to earn his title of Doctor of Chiropractic from the Palmer College ...
(Date:8/28/2015)... ... August 28, 2015 , ... SharkNinja, an innovative ... connoisseur and Emmy-nominated actress, Sofia Vergara, and unveil the Ninja® brand’s new ... technology, which delivers a variety of sizes and styles while achieving the perfect ...
(Date:8/28/2015)... Indianapolis, IN (PRWEB) , ... August 28, 2015 ... ... employee benefits advisory organization, is pleased to welcome TJS Insurance Group as its ... to employees and clients guides them and keeps them focused on their goals. ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... A complimentary ... Centers for Medicare & Medicaid Services’ (CMS) proposal to mandate bundled payments through ... webinar , “Get Ready for Game Day: Comprehensive Care for Joint Replacement,” takes place ...
Breaking Medicine News(10 mins):Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 2Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 3Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 2Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 3Health News:Sofia Vergara Partners With SharkNinja® To Launch The Ninja Coffee Bar™ 2Health News:Sofia Vergara Partners With SharkNinja® To Launch The Ninja Coffee Bar™ 3Health News:TJS Insurance Group Is Latest Partner Firm To Join United Benefit Advisors 2Health News:TJS Insurance Group Is Latest Partner Firm To Join United Benefit Advisors 3Health News:PYA Offers Complimentary CCJR Webina — Game On 2Health News:PYA Offers Complimentary CCJR Webina — Game On 3
(Date:8/28/2015)... 2015 Research and ... the "Investigation Report on China,s Insulin Aspart ... Developed by Novo Nordisk, insulin aspart (under ... drug for the treatment of diabetes. Compared with ... insulin analog, starts working fast and reports higher ...
(Date:8/28/2015)... , August 28, 2015 The scientific ... collaboration with one of the leading academics in the field ... world record holder in life extension for model animals - ... biology of aging and age-related diseases, primarily, around the stability ... has just been published as "Stability analysis of a model ...
(Date:8/28/2015)... 28, 2015  Perrigo Company plc ("Perrigo") (NYSE: ... the acquisition of leading OTC brands from GSK in ... transaction is a clear demonstration of Perrigo,s unique ability ... distribution network spanning 36 countries.  Perrigo ... commented, "We are excited to complete this transaction, which ...
Breaking Medicine Technology:China Insulin Aspart Market Report 2010-2019 - Developed by Novo Nordisk 2Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 4
Cached News: