HOME >> MEDICINE >> NEWS
Researchers identify brain pathway to explain how Fenfluramine causes weight loss

Because d-FEN targeted multiple serotonin pathways and receptors, for some patients the result was a serotonin surplus. Unfortunately, for some of these individuals, cardiac side effects developed and, consequently, the drug was removed from the market.

"Obesity is a growing problem in need of solutions," says Elmquist. "d-Fenfluramine worked very well to help patients reduce food intake and body weight. Therefore our group, headed by Lora Heisler, Ph.D., set out to identify the specific pathways and mechanisms through which d-FEN mediates its effect on food intake in the hope of more precisely understanding how appetite suppressant drugs exert their effects."

The researchers began by investigating which of the brain's neurons were being activated during d-FEN treatment and discovered activity in a region of the hypothalamus called the arcuate nucleus (ARC), the region of the brain associated with satiety or feelings of "fullness."

To determine which ARC cells were involved, coauthors Michael Cowley, Ph.D., Malcolm Low, M.D., Ph.D., and Roger Cone, Ph.D., of Oregon Health & Science University used electrophysiology methods in transgenic mice, and "tracked" d-FEN's effects in a subset of ARC cells that expressed pro-opiomelanocortin (POMC). They discovered that d-FEN significantly increased activity of these neurons.

"The technique we had earlier developed with Dr. Low for measuring the activity of the POMC neurons allowed us, for the first time, to test the direct effects of hormones, neurotransmitters and drugs on feeding circuits in the brain," explains Cone.

"In other research, we had shown that these neurons sense and respond to a variety of other signals of energy stores, including fat mass and nutrient digestion signals from the gut," adds Cowley. "This study shows how crucial these circuits are for the brain to integrate signals from the body, and shows how fenfluramine can change the interpretation of those signals."
'"/>

Contact: Bonnie Prescott
bprescot@caregroup.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
25-Jul-2002


Page: 1 2 3

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/28/2017)... ... July 28, 2017 , ... The United ... budget on nutrition assistance programs. , Right now the most public debate is ... changes to other programs are under consideration, including WIC (Women, Infants, and Children), ...
(Date:7/28/2017)... OR (PRWEB) , ... July 28, 2017 , ... Date ... http://www.GlobalDragonTV.com , Like millions of first generation immigrants before her, Rose Hong ... beneficiary of generosity and sacrifice on the part of loving parents who made sure ...
(Date:7/28/2017)... ... , ... As many parents, students, and teachers are getting ready to focus ... and address mental fatigue that can accompany long study hours, homework sessions, and grading ... only helps with school work but also in day-to-day functions on the job and ...
(Date:7/28/2017)... ... ... For over 20 years Sealy Baby has been creating crib mattresses that help ... in using some of nature’s best materials while integrating today’s latest comfort technologies to ... and crib bedding for infants and toddlers. We are thrilled that ...
(Date:7/28/2017)... ... July 28, 2017 , ... ... financial planning assistance to families and business owners in and around the greater ... held in honor of the Make-A-Wish Foundation. , The Make-A-Wish Foundation is an ...
Breaking Medicine News(10 mins):
(Date:7/28/2017)... 2017 EnvoyHealth, a Diplomat company, has partnered with ... CleverCap LITE, a technology designed to improve patient medication ... health technology solutions and services that help track and ... CleverCap LITE offers medication monitoring and control for ... Records date and time ...
(Date:7/26/2017)... a leading medical aesthetic clinic in Singapore ... conditions from the inside. The natural process of aging ... becomes more transparent due to the thinning of the epidermis. Over the ... sun contributes to aging skin, causing age spots and other types ... ...
(Date:7/25/2017)... Foundation: Curing Stomach Cancer (DDF) is excited to host its 3 rd ... & Spa in Weston, Florida beginning at 10:30 a.m.   ... Luncheon Committee Co-chair and DDF ... Co-chair Sabrina Kurzman. ... Aura Morales-Guzman, Angela Perez, DDF Board Member John Nash (of ...
Breaking Medicine Technology:
Cached News: