HOME >> MEDICINE >> NEWS
Researchers identify brain pathway to explain how Fenfluramine causes weight loss

Because d-FEN targeted multiple serotonin pathways and receptors, for some patients the result was a serotonin surplus. Unfortunately, for some of these individuals, cardiac side effects developed and, consequently, the drug was removed from the market.

"Obesity is a growing problem in need of solutions," says Elmquist. "d-Fenfluramine worked very well to help patients reduce food intake and body weight. Therefore our group, headed by Lora Heisler, Ph.D., set out to identify the specific pathways and mechanisms through which d-FEN mediates its effect on food intake in the hope of more precisely understanding how appetite suppressant drugs exert their effects."

The researchers began by investigating which of the brain's neurons were being activated during d-FEN treatment and discovered activity in a region of the hypothalamus called the arcuate nucleus (ARC), the region of the brain associated with satiety or feelings of "fullness."

To determine which ARC cells were involved, coauthors Michael Cowley, Ph.D., Malcolm Low, M.D., Ph.D., and Roger Cone, Ph.D., of Oregon Health & Science University used electrophysiology methods in transgenic mice, and "tracked" d-FEN's effects in a subset of ARC cells that expressed pro-opiomelanocortin (POMC). They discovered that d-FEN significantly increased activity of these neurons.

"The technique we had earlier developed with Dr. Low for measuring the activity of the POMC neurons allowed us, for the first time, to test the direct effects of hormones, neurotransmitters and drugs on feeding circuits in the brain," explains Cone.

"In other research, we had shown that these neurons sense and respond to a variety of other signals of energy stores, including fat mass and nutrient digestion signals from the gut," adds Cowley. "This study shows how crucial these circuits are for the brain to integrate signals from the body, and shows how fenfluramine can change the interpretation of those signals."
'"/>

Contact: Bonnie Prescott
bprescot@caregroup.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
25-Jul-2002


Page: 1 2 3

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... process to promote standards of excellence for the field of eating disorders, announces ... 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/12/2017)... Francisco, CA (PRWEB) , ... October 12, 2017 ... ... Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent ... apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... -- AVACEN Medical , Inc. (AVACEN) announced that Frost ... Product Innovation Award for Its fibromyalgia pain management device. ... device market research by Frost & Sullivan,s industry experts. ... relief product, the AVACEN 100, offers a safe and effective ... ...
(Date:10/11/2017)... , Oct. 11, 2017  True Health, ... has amplified its effort during National Breast Cancer ... hereditary cancer risks. ... Clinical Oncology calculated that more than 10 million ... inherited mutations in BRCA1 or BRCA2 and have not ...
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
Breaking Medicine Technology:
Cached News: