Researchers seek women with premature ovarian failure for testosterone replace...( it at the National Institutes of Health...),Health

Women who volunteer for the study will have the opportunity to come to NIH to be evaluated by a team of physician experts in premature ovarian failure. The evaluation will be provided at no charge, and, in most cases, patients will be reimbursed for their travel expenses.

"By participating, study volunteers will help answer questions about how best to treat patients with premature ovarian failure," Dr. Nelson said. "We also take patient education seriously, and will do our utmost to help volunteers develop a thorough understanding of their condition."

The researchers plan to recruit three groups of 55 women each. The first group of women with premature ovarian failure will wear an experimental skin patch that delivers the amount of testosterone normally produced by the ovary in healthy young women. These women will be compared to a second group of women with premature ovarian failure who will wear a placebo patch (a patch that delivers no hormone). Women in both groups will also wear a patch that delivers estrogen and take tablets containing the hormone progestin. These two groups of women will be compared with a third group of women who have normal ovarian function. All the women in the study will receive periodic scans to measure bone density as well as tests of cognition, mood, well being, sexual function, dry eye, and body composition.

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Contact: Bob Bock
rb96a@nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
15-Feb-2001