HOME >> MEDICINE >> NEWS
Resistin integral part of the inflammatory response

(Philadelphia, PA) Chronic inflammation is being implicated in diseases as widespread as cancer, heart disease, Alzheimer's disease, and most recently, diabetes and obesity. The role of the hormone resistin in people with these diseases has been questioned because it is primarily secreted by immune cells called macrophages in humans rather than fat cells, as in mice. Nevertheless, resistin is elevated in some people with diabetes and obesity. Higher levels of resistin are associated with insulin resistance. But what is the connection among inflammation, insulin resistance, and obesity?

Insulin resistance, which occurs when muscle, fat, and liver cells fail to use insulin effectively to regulate blood sugar, usually precedes type-2 diabetes and is part of metabolic syndrome. A new study from the laboratory of Mitch Lazar, MD, PhD, Chief of the Division of Endocrinology, Diabetes and Metabolism at the University of Pennsylvania School of Medicine, has found that by simulating inflammation in human macrophages and patients levels of resistin substantially increase. In people, the resistin level in blood increases by about 400 percent. "This suggests that resistin is part of the inflammatory process," says Lazar. "This leads us to hypothesize that human resistin also contributes to insulin resistance." He and colleagues published their findings in the November 30 issue of PloS, Medicine.

Since several inflammatory molecules called cytokines are increased in the blood of people with obesity, the human body seems to react in the same way to wounds and infections as it does to obesity. This may mean that obesity in humans causes immune cells like macrophages to overproduce resistin in reaction to the cytokines, thereby promoting diabetes through insulin resistance.

The Lazar team also treated human macrophages with endotoxin, a product of bacteria that stimulates inflammation. Resistin levels increased forty-fold in cell cultures of these imm
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
29-Nov-2004


Page: 1 2

Related medicine news :

1. Biochip for detection of inflammatory bowel disease
2. Generic anti-inflammatory causes significantly fewer GI complications than branded medications
3. Twenty-Year prospective study of pregnant women with inflammatory bowel disease finds healthy babies
4. Proinflammatory mononuclear cells in obese found to contribute to diabetes, heart disease
5. COX-2 inhibitor could be safest anti-inflammatory drug for older people
6. Hopkins researchers find MRI useful tool in diagnosing inflammatory bowel diseases in children
7. A pair of discoveries helps unravel complex genetics of inflammatory bowel disease
8. Anti-inflammatory drugs speed brain recovery in Stanford animal study
9. Protein identified that may play central role in inflammatory bowel disease
10. Experts to discuss the affects of non-steroidal anti-inflammatory drugs (NSAIDs)
11. Existing anti-inflammatory drug could help children suffering from an inherited bone disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... MemoryCare.com, a comprehensive resource ... Memory Care Facilities in Louisville, KY. The guide identifies 17 memory care communities ... to the Alzheimer’s Association , 5.6 million people age 65 and older ...
(Date:9/2/2020)... ... 02, 2020 , ... RAM Technologies, Inc., the perennial leader ... Special Needs plans, is proud to support the 2020 National Conferences on Medicare, ... supporting the event as a sponsor and exhibitor and will be showcasing their ...
(Date:9/1/2020)... ... , ... KitoTech Medical, a Seattle-based medical device company, announced ... used to accelerate the commercialization of its microMend® family of wound closure products. ... expand its customer base of healthcare systems as well as independent hospitals and ...
(Date:9/1/2020)... COSTA MESA, Calif. (PRWEB) , ... September 01, 2020 , ... ... on the “safe side”, the Cohn Health Institute has taken this time ... decades. In celebration of its 30th Anniversary, the Cohn Health Institute will be relaunching ...
(Date:8/31/2020)... ... August 31, 2020 , ... Cardiothoracic surgeons at Allegheny General ... Carnegie Mellon University (CMU) to develop a new heart monitoring device designed to ... surgery. , The AGH/CMU team was recently awarded a “Trailblazer” grant from the ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... August 27, 2020 , ... The GHT Companies ... its fundraising initiative for Feeding San Diego with a press conference at ... Companies presents the final check of $5,000.00+ representing an overall donation result exceeding $30,000 ...
(Date:8/26/2020)... CHARLES, Mo. (PRWEB) , ... ... ... Services, a member of Eurofins BioPharma Services, Laboratory Testing division, expands its ... the existing suite of Flow Cytometry platforms available. With industry-leading biomarker solutions, ...
(Date:8/26/2020)... ... ... As the U.S. struggles in its 6th month of fighting Covid-19, Americans are ... keep your distance, wash your hands. Prevention is the best tool for now. Noted ... much better it is to prevent disease than to cure it.” , Part of ...
Breaking Medicine Technology:
Cached News: