HOME >> MEDICINE >> NEWS
Results from first clinical trial using GVG to treat addiction

UPTON, NY -- Using an experimental addiction treatment first investigated at the U.S. Department of Energy's Brookhaven National Laboratory, a team of scientists from Brookhaven, the New York University (NYU) School of Medicine, and a national addiction treatment center in Mexico report prolonged abstinence and the elimination of drug craving in eight out of 20 hard-core, long-term cocaine addicts who enrolled in the study. This is the first human clinical data showing that gamma vinyl-GABA (GVG, vigabatrin) holds promise as a pharmacological treatment for cocaine addiction. The results will appear in the December 1, 2003, issue of the journal Synapse, available online September 22, 2003 (http://www3.interscience.wiley.com/cgi-bin/jissue/104552849).

"It is extremely gratifying to see these early human results bear out what we've observed in our extensive preclinical animal studies with GVG," said Brookhaven neuroanatomist Stephen Dewey, who has been using animal models and brain imaging techniques to investigate GVG's effects on neurochemistry and addictive behavior for more than ten years. These animal experiments have shown that GVG can block drug-induced increases in brain dopamine (a chemical associated with reward and pleasure, which is elevated by all addictive drugs), drug-seeking behavior, drug self-administration and sensitization, and drug craving -- even that triggered by environmental cues (see http://www.bnl.gov/PET/GVG/).

"This promising work on a potential treatment for drug addiction illustrates the value of the Department of Energy's basic research in physics, chemistry, and imaging sciences," said Secretary of Energy Spencer Abraham. "The advanced technologies developed in the DOE laboratories are being applied to a number of critical national health issues, including the problem of drug abuse."

Said lead autho
'"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
22-Sep-2003


Page: 1 2 3

Related medicine news :

1. Heart transplant survival: Results may be key to rejection prevention, detection, treatment
2. Docetaxel versus paclitaxel in breast cancer Results of worlds first head to head trial
3. Results of first chronic treatment study with oral EXANTA(TM) (ximelagatran)
4. Media Advisory-- Results of California autism epidemiology study to be unveiled
5. Results of Yale study confirm aspirin helpful in preventing a first heart attack
6. Results of NUVANCE (IL-4 receptor) in Phase I/II study in asthma patients featured at AAAAI Late-Breaker Abstract and Asthma Therapy Sessions
7. Yale study shows way to re-stimulate brain cell growth: Results could boost understanding of Alzheimers, other brain disorders
8. Results of NUVANCE phase I/II asthma trial presented
9. ILEX Oncology & LeukoSite report results from pivotal Phase II CAMPATH (R) trial; Results suggest new hope for refractory chronic lymphocytic leukemia
10. UI Study Yields Encouraging Results For New Breast Cancer Treatment
11. Ph.D. Degree Research Results In Patent For Low-Cost Pharmaceutical Filters Made From Seafood Waste

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2018)... ... December 06, 2018 , ... The University of ... install LED light fixtures containing Indigo-Clean continuous environmental disinfection. The lights are ... the forefront of collegiate gymnastics programs across the nation by providing this new, proven ...
(Date:12/5/2018)... DALLAS, Texas (PRWEB) , ... December 05, 2018 ... ... proved its leading SkinPen Precision device is setting a new standard as the ... Aesthetics Everything win. , Each year this award is presented at the renowned ...
(Date:12/5/2018)... ... December 05, 2018 , ... ... patient and family engagement with the use of the Precision Virtual Reality® ... provides Children’s National’s world-renowned neurosurgeons and physicians with a never-before view of ...
(Date:12/5/2018)... ... December 05, 2018 , ... Marking its seventh year, ... celebration “A Toast Heard ‘Round the World” on New Year’s Eve. Each year ... global community (alumni, students, faculty members, staff, families, and friends of the institution) to ...
(Date:12/5/2018)... Ill. (PRWEB) , ... December 05, 2018 , ... ... CRO, FSP, Strategic Resourcing, and Consulting services, announced its new office location in ... will accommodate organic growth of clinical trial operations in Europe and additional in-country ...
Breaking Medicine News(10 mins):
(Date:12/5/2018)... ... 05, 2018 , ... NDA Partners Chairman Carl Peck, ... Laboratory Integration at the United States Pharmacopeial Convention (USP), has joined the firm ... experience in domestic and international operations harmonization, compendial affairs, and the development and ...
(Date:11/29/2018)... Fla. (PRWEB) , ... November 29, 2018 , ... ... practitioner-channel dietary supplement company – announced today the launch of the Annatto-E™ product ... annatto plant (Bixa orellana). Backed by clinical research, DFH’s new Annatto-E™ products are ...
(Date:11/29/2018)... ... ... Windsor Gardens Healthcare Center of the Valley (“Windsor Gardens”), a skilled ... selected by the California Association of Health Facilities (CAHF) as only one of 20 ... California Department of Public Health awarded a grant of $700,000 to CAHF to develop ...
Breaking Medicine Technology:
Cached News: