Results of NUVANCE phase I/II asthma trial presented

Once-a-Week Inhaled Treatment Helped Stabilize Lung Function and Was Generally Well Tolerated

MADRID, SPAIN - Results of a Phase I/II trial of NUVANCE (soluble IL-4 receptor), an investigational once-a-week inhaled asthma treatment, suggest the drug was generally well tolerated and helped stabilize lung function for up to 12 weeks following discontinuation of inhaled corticosteroids, Immunex Corporation (NASDAQ: IMNX) announced today. These results were presented today at the European Respiratory Society meeting in Madrid, Spain.

"Asthma has reached epidemic growth levels. IL-4 inhibition may change the way physicians think about asthma," said Dr. Larry Borish, associate professor in medicine, University of Virginia Medical Center and principal investigator for the NUVANCE trial. "The data presented today provide the foundation for further study of NUVANCE and IL-4 inhibition in asthma."

NUVANCE, a recombinant human version of a naturally occurring protein, represents a novel investigational approach to treating asthma. NUVANCE acts by binding to Interleukin-4 (IL-4), a protein that is present in asthmatic lungs. The binding of NUVANCE to IL-4 renders the bound IL-4 biologically inactive, which may reduce the IL-4 driven signs and symptoms of asthma.

This placebo-controlled, randomized, double-blind, Phase I/II trial was conducted in 62 adults with moderate persistent asthma, in which symptoms such as wheezing, shortness of breath and coughing occur regularly. Prior to the study, all patients were dependent on inhaled corticosteroids, daily medication intended to relieve inflammation of the airways. All patients discontinued inhaled corticosteroids when study treatment was started.

The study assessed the safety and pharmacokinetics (absorption, distribution and elimination) of inhaled NUVANCE following discontinuation of inhaled corticosteroids. Investig

Contact: Tim Warner
Immunex Corporation

Page: 1 2 3 4

Related medicine news :

1. Heart transplant survival: Results may be key to rejection prevention, detection, treatment
2. Docetaxel versus paclitaxel in breast cancer Results of worlds first head to head trial
3. Results from first clinical trial using GVG to treat addiction
4. Results of first chronic treatment study with oral EXANTA(TM) (ximelagatran)
5. Media Advisory-- Results of California autism epidemiology study to be unveiled
6. Results of Yale study confirm aspirin helpful in preventing a first heart attack
7. Results of NUVANCE (IL-4 receptor) in Phase I/II study in asthma patients featured at AAAAI Late-Breaker Abstract and Asthma Therapy Sessions
8. Yale study shows way to re-stimulate brain cell growth: Results could boost understanding of Alzheimers, other brain disorders
9. ILEX Oncology & LeukoSite report results from pivotal Phase II CAMPATH (R) trial; Results suggest new hope for refractory chronic lymphocytic leukemia
10. UI Study Yields Encouraging Results For New Breast Cancer Treatment
11. Ph.D. Degree Research Results In Patent For Low-Cost Pharmaceutical Filters Made From Seafood Waste

Post Your Comments:

(Date:2/12/2019)... OMAHA, Neb. (PRWEB) , ... ... ... leading healthcare market research and consulting organization, devoted to helping hospital leaders, ... designed website at http://www.prccustomresearch.com . The website now features a streamlined ...
(Date:2/12/2019)... ... February 12, 2019 , ... A ... to a brief, office-based visit, won the top award at the 9th annual ... Brittany Berry-Pusey presented the winning pitch, nabbing a combined first prize of $15,000. ...
(Date:2/12/2019)... ... 12, 2019 , ... Accreditation Commission for Health Care (ACHC) ... Care. This agreement allows Rhode Island Partnership for Home Care members to receive ... well as discounts on ACHCU educational resources that help prepare association members for ...
(Date:2/11/2019)... ... February 11, 2019 , ... ... SmartLinx Solutions because the integrated suite could more effectively manage its ... Ready, Time Systems International, and Paycom client, Caring Health chose SmartLinx to automate ...
(Date:2/6/2019)... ... February 06, 2019 , ... ... system partners have contracted to offer Krames On FHIR®. Using SMART On FHIR® ... and seamlessly into the clinician’s workflow. Its connectivity enables access to award-winning patient ...
Breaking Medicine News(10 mins):
(Date:2/13/2019)... ... 13, 2019 , ... Researchers from the Icahn School of Medicine at Mount ... part of the National Institutes of Health (NIH), for a five-year program called the ... goals are to establish follicle-stimulating hormone (FSH), an important part of the reproductive system ...
(Date:2/13/2019)... ... ... According to the National Health and Nutrition Survey of the CDC, the ... overweight (the healthy range is 18.4-24.9). [1] This steadily increasing trend toward obesity picked ... news outlets are regularly reporting it as a crisis. [2] With this increased focus ...
(Date:2/13/2019)... DALLAS (PRWEB) , ... February 13, 2019 , ... The ... Association of Staff Physician Recruiters (ASPR). “The Medicus Firm has been a vocal ... years. Industry stewardship and support of educational programs are part of our DNA ...
Breaking Medicine Technology:
Cached News: