HOME >> MEDICINE >> NEWS
Retrospective Statistical Analysis Corroborates Early Results Of Randomized Breast Cancer Trials

randomized trials can be replaced, but careful statistical analysis of patient registries, databases of patient characteristics and treatment information, can provide information to direct further inquiry, he said.

"There are circumstances, in which 'non-randomized' comparisons can be informative, and they can be even more informative when the sample sizes are large," Berry said. "These circumstances are present when assessing possible benefits of bone marrow transplant in metastatic breast cancer." Berry's statistical analysis compared metastatic breast cancer patients who participated in four clinical trials conducted by the Cancer and Leukemia Group B (CALGB) with that of metastatic breast cancer patients included in the Autologous Blood and Marrow Transplant Registry (ABMTR). The 663 CALGB patients included had been treated with various conventional chemotherapy regimens from 1980 to 1992, while the 638 ABMTR patients were treated with various regimens of high-dose chemotherapy with bone marrow or stem cell transplants from 1989 to 1995.

The CALGB trials were initially conducted to compare various chemotherapy regimens, but no survival differences were seen for patients with metastatic breast cancer, within each trial or across the trials. Berry looked for treatment-related differences within ABMTR, but found none. Thus the two separate patient groups were compared to see if the high dose chemotherapy used in ABMTR provided any survival benefit for metastatic breast cancer patients.

As the standard for evaluating new treatments, randomized clinical trials usually pit a new cancer treatment against the standard treatment to see if one is more effective or has fewer or more-tolerable side effects. Patients who meet requirements and agree to enter the trials are randomly assigned into the group getting the standard therapy or the group getting the experimental therapy.

Hundreds of patients are usually needed for researchers to
'"/>

Contact: Joanna Downer
downe010@mc.duke.edu
919-684-4148
Duke University Medical Center
15-May-1999


Page: 1 2 3

Related medicine news :

1. Analysis of tamoxifen studies reveals slight increase of stroke risk
2. Analysis finds drug improves odds of complete stroke recovery
3. Analysis of study looks at why quitters return to smoking
4. Analysis suggests women treated for breast cancer do better with axillary node dissection
5. New U-M Analysis Of Brain At Work
6. Meta-Analysis Of The Efficacy Of Sildenafil (ViagraTM) In The Treatment Of Severe Erectile Dysfunction
7. Digital Speech Analysis Tests Sobriety
8. Early onset of puberty the EU gets serious
9. Early HIV screening prolongs life and is affordable, Stanford study shows
10. Early supported discharge services can reduce long term dependency for stroke patients
11. Early surgical treatment not always necessary for patients with brain haemorrhage

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/19/2019)... ... August 19, 2019 , ... Professional Enrollment ... Antonio, Texas, proudly announces they have ranked #3056 on the 2019 Inc. 5000 ... a unique look at the most successful companies within the American economy's most ...
(Date:8/19/2019)... ... August 18, 2019 , ... ... its third product, Aqua+, adding two SKUs to its line of functional offerings. ... more effectively than water alone. Distinguishing Aqua+ from other rehydration solutions is the ...
(Date:8/16/2019)... ... August 16, 2019 , ... Inc. magazine today revealed that ... prestigious ranking of the nation’s fastest-growing private companies. The list represents a unique ... independent small businesses. Microsoft, Dell, Domino’s Pizza, Pandora, Timberland, LinkedIn, Yelp, Zillow, and ...
(Date:8/16/2019)... HYDE PARK, N.Y. (PRWEB) , ... August 16, ... ... designed, fabricated, and donated a custom handcrafted, one-of-a-kind children’s aircraft to Ronald McDonald ... was designed to give children residents undergoing medical treatments and their family ...
(Date:8/15/2019)... ... 15, 2019 , ... Inc. magazine revealed yesterday that Georgetown ... prestigious ranking of the nation’s fastest-growing private companies. The list represents a unique ... independent small businesses. Microsoft, Dell, Domino’s Pizza, Pandora, Timberland, LinkedIn, Yelp, Zillow, and ...
Breaking Medicine News(10 mins):
(Date:8/19/2019)... ... August 19, 2019 , ... Physician Partners ... will join its Richardson, Texas location, starting Monday, Sep. 2nd. , Dr. Spiro ... a subspecialty board certification in pain management. , Dr. Khoury attended the American ...
(Date:8/17/2019)... ... ... The American Legion Dorchester Post 91 in Cambridge, Md., donated another $16,000 ... of veteran patients, adding to a donation in the same amount it made to ... donation from Post 91 will enable the VA Maryland Health Care System to purchase ...
(Date:8/16/2019)... ... 16, 2019 , ... A new medical device for treating ... both corrects the curve and maintains flexibility in the spine. , The FDA’s ... medical staff of Shriners Hospitals for Children® — Philadelphia. It is the first ...
Breaking Medicine Technology:
Cached News: