Review identifies factors leading to better outcome for some metastatic breast cancer patients

DURHAM, N.C.--Duke University Medical Center researchers have identified a subset of patients with advanced breast cancer who had greater success than other patients treated with experimental high-dose chemotherapy followed by bone marrow transplant.

In a retrospective review of a previous Duke study of 425 patients, now with an average of six years' follow-up, of the 299 patients who had high-dose chemotherapy with transplant, those patients who had previously received hormone therapy with the drug tamoxifen, but had not previously received chemotherapy and had no tumors beyond the chest wall and lymph nodes were more likely to live longer than the other patients.

The findings of the Duke study, published in the October Journal of Clinical Oncology, can help physicians select which metastatic breast cancer patients might benefit most from aggressive therapy and suggest restructuring follow-up treatment for patients at high risk for recurrence or new spread of disease, according to the authors.

"Right now high-risk patients are followed with a symptom-based approach--if there's a problem or change in symptoms then tests are done to see why," said lead author Dr. David Rizzieri. "Instead, at-risk patients should be followed very closely, with routinely scheduled physical, radiographic and laboratory tests to catch recurrence early, before symptoms appear. We want to hit the disease early, and hit it hard."

Because of its greater toxicity and a dearth of clinical trials comparing it to standard treatments, high-dose chemotherapy with bone marrow transplant is a controversial treatment for breast cancer patients. Nevertheless, many patients have been demanding the treatment, believing it to be their last hope. At the American Society for Clinical Oncology (ASCO) annual meeting in May, other scientists reported preliminary results of an ongoing randomized clinical trial that demonstrated no survival difference between a high-dose treatment grou

Contact: Joanna Downer
Duke University Medical Center

Page: 1 2 3 4

Related medicine news :

1. Review supports link between HRT and stroke
2. Updated press release to October 2004 Cochrane Review
3. Rice bioengineer named to Technology Reviews TR100
4. Review of preliminary observations concludes the Mayo Clinic Natl Conf on Medicine and the Media
5. Livers From Children Are Going To Adults, University Of Pittsburgh Review Of National Data Reveals
6. Optical technique identifies vulnerable plaques in cardiac patients
7. CAS science spotlight identifies most requested article
8. Student identifies electrical changes preceding heart failure
9. Mayo Clinic identifies key cellular process in prostate and other cancers
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. Cell marker identifies patients who are more likely to respond to taxol

Post Your Comments:

(Date:8/31/2020)... ... 2020 , ... In an effort to give back to the community in ... each hotel room booked with a special new rate code to benefit children and ... effective immediately. Donations will be applied to any room type, any time, now ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... intended to improve outcomes for patients with advanced heart failure, today announced that ... grant in the amount of $555,358 from the National Heart, Lung, and Blood ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst & Young LLP (EY ... Entrepreneur Of The Year® 2020 Florida Award finalist. Now in its 34th year, ... innovation, growth and prosperity as they build and sustain successful businesses that transform ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... to a customized Lighthouse Health & Wellness mobile app and web-portal. NCPCV received ... Motorola Solutions Foundation awards grants each year to organizations, such as Destination Imagination, ...
(Date:8/28/2020)... ... August 28, 2020 , ... Integrated Viral Protection (IVP ... Florida school to deploy its breakthrough Mobile Biodefense Indoor Air Protection System that is ... Classical Academy plans to fully reopen equipped with the filtration system on September 8th. ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... (PRWEB) , ... August 26, ... ... member of Eurofins BioPharma Services, Laboratory Testing division, expands its technology footprint ... suite of Flow Cytometry platforms available. With industry-leading biomarker solutions, complemented with ...
(Date:8/26/2020)... ... August 26, 2020 , ... As the U.S. struggles ... daily routine for preventing the Coronavirus. Wear a mask, keep your distance, wash your ... Dr. Denis Burkitt said it best in 1977, “How much better it is to ...
(Date:8/26/2020)... NEW YORK (PRWEB) , ... August 26, 2020 ... ... the nation’s largest non-profit organization devoted to funding innovative lymphoma research and serving ... marking its 25th Anniversary with a special virtual LRF Gala and Charity ...
Breaking Medicine Technology:
Cached News: