Rutgers research shows caffeine may prevent s...( hers found it inhibited ultraviolet lig...),Health

hers found it inhibited ultraviolet light-induced tumors and cancers in this case, as well. Conney cites advantages to using the direct skin application over oral administration, pointing to the ability to provide more highly concentrated doses and larger overall dosages. "Whether you can give enough orally to be effective in humans is not known," said Conney. "Whether people could ingest that amount without becoming hyperactive is also a real question mark."

The newly published study also reported the highly selective action of both caffeine and EGCG in killing cancer cells. Adjacent normal skin cells were not affected. "The discovery of this selectivity was very exciting to us," said Conney. "Also, in our study it didn't matter if the tumors were benign or malignant; cells in both were killed while leaving the normal cells alone."

The study suggests further research is needed to determine whether or not the skin application of these agents would be effective in people. The researchers anticipate human clinical trials in the near future. "For now," said Conney, "if you are a mouse, it would be terrific. In people we just don't know yet."

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Contact: Joseph Blumberg
blumberg@ur.rutgers.edu
732-932-7084
Rutgers, the State University of New Jersey
26-Aug-2002

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