HOME >> MEDICINE >> NEWS
Rutgers researcher finds brain connections may reorganize in Parkinson's disease

ind-limb cluster and act like a regular hind-limb neuron. The problem is that the neuron now receives hind-limb signals but maintains its original downstream communication with the fore-limb. The result is that the brain is unable to process these signals to control movement of the fore-limb.

"We saw this switching of connectivity happening throughout the basal ganglia and impacting many different body parts," said West. "In some cases these neurons would affiliate with more than one cluster, making accurate response to stimulation, such as touch, almost impossible."

According to West, this connection switching appears permanent, with these changes still evident up to a year after dopamine loss. "These switched connections may explain why L-DOPA and other drugs are unable to restore complex sensorimotor behaviors such as maintaining manual contact with an unseen moving object."

Although conducted with animal models, West's research is applicable to Parkinson's disease in humans. "Human studies of the basal ganglia show overlapping areas that control leg and arm movements organized similarly to rats, which means it is possible for connections to get switched in the human brain just as in the rat brain."

West's results are also consistent with previous studies that have shown that loss of dopamine in humans and animals causes the cortex to sprout new connections to the basal ganglia.

"These kinds of changes in connections would essentially make curing Parkinson's disease difficult or impossible," he explained.

West hopes his findings, which show apparently permanent changes caused by the loss of dopamine to the brain, will encourage more research focused not only on treating, but also preventing, Parkinson's disease.


'"/>

Contact: Stacey Hersh
shersh@ur.rutgers.edu
732-932-7084
Rutgers, the State University of New Jersey
3-Sep-2002


Page: 1 2

Related medicine news :

1. Rutgers College of Nursing faculty member is funded to develop an interactive computer system
2. Rutgers-Newark researchers link early movement, brain development
3. Rutgers-developed biomaterial drives a technology transfer story toward success
4. Rutgers scientists pinpoint brain cells involved in drug addiction relapse
5. Rutgers researcher: Brains in dyslexic children can be rewired to improve reading skills
6. Rutgers study shows learning ability under stress still strong in Prozac-treated females
7. Rutgers wins funds to create online index of moving brain images
8. Rutgers research shows caffeine may prevent skin cancer
9. Rutgers announces Robert Wood Johnson Foundation Investigator Awards in Health Policy Research
10. International Thiamine (Vitamin B-1) Conference at Rutgers Newark
11. Rutgers develops virtual reality treatment for hand impairment in chronic stroke patients

Post Your Comments:
(Date:4/17/2014)... It,s estimated that as many as 10 million older ... of loneliness and isolation. , However, new research ... retired older Americans for six years found that ... of depression by more than 30 percent. , "That,s ... State University professor of telecommunication, information studies and media ...
(Date:4/17/2014)... April 17, 2014 EcoHealth Alliance, a nonprofit ... issues, published a comprehensive review today examining the current ... virus. The review calls for improved global surveillance strategies ... the recent outbreak of Ebola in West Africa that ... countries of Guinea and Liberia. According to the ...
(Date:4/17/2014)... not uncommon these days to find a colored ribbon representing ... breast cancer. But what color ribbon does one think of ... designated color, for many suffering from the disease, black may ... University study consisting of lung cancer patients, primarily smokers between ... more light on the stigma often felt by these patients, ...
(Date:4/17/2014)... 2014While 94 per cent of Canadians surveyed said they ... for a specific number of genetic conditions, only 80 ... in screening that would sequence their newborns, genomes.,Most newborns ... their first day or two of life in which ... heels and tested for about five to 54 conditions, ...
(Date:4/16/2014)... Calif. Consider the marvel of the embryo. It begins ... function as they multiply to become the cells of our ... the body. , Now, in a feat of reverse tissue ... genetic coding that allows embryonic cells to proliferate and transform ...
Breaking Medicine News(10 mins):Health News:Internet use can help ward off depression among elderly 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:Unraveling the 'black ribbon' around lung cancer 2Health News:Researcher looks at public perceptions around newborn testing 2Health News:Researcher looks at public perceptions around newborn testing 3Health News:Stanford scientists develop 'playbook' for reverse engineering tissue 2Health News:Stanford scientists develop 'playbook' for reverse engineering tissue 3
(Date:1/15/2014)... FORT WORTH, Texas , Jan. 15, 2014  Humberto ... in Dermatology Achievement Award" from the Journal of ... Dermatology Aesthetic & Clinical Conference (ODAC). The event is January ... Florida . The ...
(Date:1/15/2014)... is very pleased to announce the appointment of Mr. ... Mark was promoted from his current role of Chief Operating ... in Massachusetts , Mississippi ... 2012 with 20+ years of broad-based operations, sales, engineering and ...
(Date:1/15/2014)... 2014  According to Millennium Research Group (MRG), the ... the United States and European ... expand moderately through 2022, with embolization particles representing ... interest in drug-eluting beads (DEBs) and radioembolization spheres ...
Breaking Medicine Technology:Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
Cached News: