HOME >> MEDICINE >> NEWS
Rutgers researcher finds brain connections may reorganize in Parkinson's disease

ind-limb cluster and act like a regular hind-limb neuron. The problem is that the neuron now receives hind-limb signals but maintains its original downstream communication with the fore-limb. The result is that the brain is unable to process these signals to control movement of the fore-limb.

"We saw this switching of connectivity happening throughout the basal ganglia and impacting many different body parts," said West. "In some cases these neurons would affiliate with more than one cluster, making accurate response to stimulation, such as touch, almost impossible."

According to West, this connection switching appears permanent, with these changes still evident up to a year after dopamine loss. "These switched connections may explain why L-DOPA and other drugs are unable to restore complex sensorimotor behaviors such as maintaining manual contact with an unseen moving object."

Although conducted with animal models, West's research is applicable to Parkinson's disease in humans. "Human studies of the basal ganglia show overlapping areas that control leg and arm movements organized similarly to rats, which means it is possible for connections to get switched in the human brain just as in the rat brain."

West's results are also consistent with previous studies that have shown that loss of dopamine in humans and animals causes the cortex to sprout new connections to the basal ganglia.

"These kinds of changes in connections would essentially make curing Parkinson's disease difficult or impossible," he explained.

West hopes his findings, which show apparently permanent changes caused by the loss of dopamine to the brain, will encourage more research focused not only on treating, but also preventing, Parkinson's disease.


'"/>

Contact: Stacey Hersh
shersh@ur.rutgers.edu
732-932-7084
Rutgers, the State University of New Jersey
3-Sep-2002


Page: 1 2

Related medicine news :

1. Rutgers College of Nursing faculty member is funded to develop an interactive computer system
2. Rutgers-Newark researchers link early movement, brain development
3. Rutgers-developed biomaterial drives a technology transfer story toward success
4. Rutgers scientists pinpoint brain cells involved in drug addiction relapse
5. Rutgers researcher: Brains in dyslexic children can be rewired to improve reading skills
6. Rutgers study shows learning ability under stress still strong in Prozac-treated females
7. Rutgers wins funds to create online index of moving brain images
8. Rutgers research shows caffeine may prevent skin cancer
9. Rutgers announces Robert Wood Johnson Foundation Investigator Awards in Health Policy Research
10. International Thiamine (Vitamin B-1) Conference at Rutgers Newark
11. Rutgers develops virtual reality treatment for hand impairment in chronic stroke patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Dr. Alan ... surgery in New York City. He is known for his distinguished expertise and ... vascular surgery, Dr. Benvenisty holds sub-specialty training in treating renovascular disease and aortic ...
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. Nicholas Rallis and Chris ... spent 10 years as clinical instructors for the reputable Full Mouth Rehabilitation continuing ... the program, private practitioners receive cutting-edge clinical training and learn how to perform ...
(Date:5/24/2017)... ... May 24, 2017 , ... STATEMENT OPPOSING PRESIDENT DONALD TRUMP’S ... Donald Trump’s budget, “A New Foundation for American Greatness—President's Budget FY 2018,” because ... marginalizes underserved populations, undermines productivity, and destroys the social safety net needed by ...
(Date:5/24/2017)... (PRWEB) , ... May 24, ... ... affecting the female reproductive tract in which the endometrial lining of the ... causing inflammation and pain. Patients experiencing painful intercourse, painful periods, pelvic pain, ...
(Date:5/24/2017)... ... ... If you are thinking of a visit to San Francisco , fall is a ... time to visit. , Business Architecture Associates is pleased to offer 5 days of training ... 4-½ day package for individuals, and as 4-½ day corporate package for up to 3 ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... , May 10, 2017 Radiology has become ... its costs have also spiraled to the number one ... to radiology than ever before as the most complete ... a patient with lower back pain an MRI may ... reason for pain, resulting in entirely different treatment protocols.  ...
(Date:5/9/2017)...  Semler Scientific, Inc. (OTCQB: SMLR), an emerging ... the clinical effectiveness and efficiency of healthcare providers, ... ended March 31, 2017. "We ... identify when preventive care options are appropriate, which ... attacks or strokes occur," said Doug Murphy-Chutorian ...
(Date:5/6/2017)...  Hill-Rom Holdings, Inc. (NYSE: HRC), has begun a ... to its Welch Allyn campus. The ... more than 100 new jobs to Central ... a significant presence for more than 100 years. Hill-Rom,s ... large portion of which will be R&D and engineering ...
Breaking Medicine Technology:
Cached News: