HOME >> MEDICINE >> NEWS
Rutgers researcher finds brain connections may reorganize in Parkinson's disease

ind-limb cluster and act like a regular hind-limb neuron. The problem is that the neuron now receives hind-limb signals but maintains its original downstream communication with the fore-limb. The result is that the brain is unable to process these signals to control movement of the fore-limb.

"We saw this switching of connectivity happening throughout the basal ganglia and impacting many different body parts," said West. "In some cases these neurons would affiliate with more than one cluster, making accurate response to stimulation, such as touch, almost impossible."

According to West, this connection switching appears permanent, with these changes still evident up to a year after dopamine loss. "These switched connections may explain why L-DOPA and other drugs are unable to restore complex sensorimotor behaviors such as maintaining manual contact with an unseen moving object."

Although conducted with animal models, West's research is applicable to Parkinson's disease in humans. "Human studies of the basal ganglia show overlapping areas that control leg and arm movements organized similarly to rats, which means it is possible for connections to get switched in the human brain just as in the rat brain."

West's results are also consistent with previous studies that have shown that loss of dopamine in humans and animals causes the cortex to sprout new connections to the basal ganglia.

"These kinds of changes in connections would essentially make curing Parkinson's disease difficult or impossible," he explained.

West hopes his findings, which show apparently permanent changes caused by the loss of dopamine to the brain, will encourage more research focused not only on treating, but also preventing, Parkinson's disease.


'"/>

Contact: Stacey Hersh
shersh@ur.rutgers.edu
732-932-7084
Rutgers, the State University of New Jersey
3-Sep-2002


Page: 1 2

Related medicine news :

1. Rutgers College of Nursing faculty member is funded to develop an interactive computer system
2. Rutgers-Newark researchers link early movement, brain development
3. Rutgers-developed biomaterial drives a technology transfer story toward success
4. Rutgers scientists pinpoint brain cells involved in drug addiction relapse
5. Rutgers researcher: Brains in dyslexic children can be rewired to improve reading skills
6. Rutgers study shows learning ability under stress still strong in Prozac-treated females
7. Rutgers wins funds to create online index of moving brain images
8. Rutgers research shows caffeine may prevent skin cancer
9. Rutgers announces Robert Wood Johnson Foundation Investigator Awards in Health Policy Research
10. International Thiamine (Vitamin B-1) Conference at Rutgers Newark
11. Rutgers develops virtual reality treatment for hand impairment in chronic stroke patients

Post Your Comments:
(Date:7/29/2014)... Wailea, Maui, HI (PRWEB) July 29, 2014 ... Four Seasons Resort Maui at Wailea. This September through ... many of them free-- tailored to couples of all ages ... great and guests can take advantage of the Resort's popular ... to $1,000 while the "twice yearly sale" is in full ...
(Date:7/29/2014)... Tucson-based company Outski has created a ... and wellness program, called 401(play)™. A 401(play)™ plan promotes ... for employees to use their earned vacation time. In ... the amount of each paycheck to be put into ... offering a 401(play)™ plan to in several ways; for ...
(Date:7/29/2014)... In today’s world, a good night’s sleep has become especially ... (a medical problem where the airway collapses during sleep and ... rest they need to face their daily challenges. , ... people in the United States alone have sleep apnea. Of ... those treated, many cannot tolerate their prescribed medical device known ...
(Date:7/29/2014)... Dallas, Texas (PRWEB) July 29, 2014 Guests ... , will be indulged in a new sleep experience. The ... INTENTIONS™ Linens by Peacock Alley. , These expertly crafted, ... simple striped pattern from a distance, yet upon closer look, ... gentle reminders to relax, sleep and breathe. , ...
(Date:7/29/2014)... The Multiple System Atrophy Coalition, a growing nonprofit ... five new members to its Board of Directors. ... its executive directors. The MSA Coalition now has ... Advisors. These 12 dedicated volunteers are fully focused ... advocacy and research funding for the neurological disorder Multiple ...
Breaking Medicine News(10 mins):Health News:Four Seasons Resort Maui at Wailea Goes All Out to Give Couples Memorable Get-Away this Fall at Maui’s Luxury Resort 2Health News:Four Seasons Resort Maui at Wailea Goes All Out to Give Couples Memorable Get-Away this Fall at Maui’s Luxury Resort 3Health News:Outski launches 401(play)™ Plan to Employers as Part of an Employee Benefit / Health and Wellness Program 2Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Auberge Du Soleil Offers INTENTIONS™ by Peacock Alley on Guests' Beds Providing a Unique Sleep Experience 2Health News:The Multiple System Atrophy Coalition Appoints Five New Members to Board of Directors 2Health News:The Multiple System Atrophy Coalition Appoints Five New Members to Board of Directors 3Health News:The Multiple System Atrophy Coalition Appoints Five New Members to Board of Directors 4
(Date:7/28/2014)... 2014  A prospective study conducted by the ... has validated the performance of VolparaDensity breast imaging ... volumetrically assessed breast density measurements to breast cancer ... Prevention (DOI: 10.1158/1055-9965.EPI-13-1219), the article, "Automated measurement ... breast cancer risk assessment," was authored by ...
(Date:7/28/2014)... , July 28, 2014  TNI BioTech, Inc. ... company focused on the development, marketing and distribution ... filed definitive proxy materials with the Securities and ... Meeting of Shareholders to be held on Thursday, ... Time. The record date for determining those shareholders ...
(Date:7/28/2014)... , July 28, 2014  ResMed (NYSE: ... products for the treatment of sleep-disordered breathing and other ... Germany against Taiwanese medical device ... headgear used on APEX WiZARD 210 and 220 masks.  ... in Munich , is appealable, and ...
Breaking Medicine Technology:Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 2Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 4TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 2TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 3ResMed Receives Permanent Injunction against APEX in Germany, Continues Enforcement of Patents in Europe 2
Cached News: