HOME >> MEDICINE >> NEWS
Rutgers researcher finds brain connections may reorganize in Parkinson's disease

ind-limb cluster and act like a regular hind-limb neuron. The problem is that the neuron now receives hind-limb signals but maintains its original downstream communication with the fore-limb. The result is that the brain is unable to process these signals to control movement of the fore-limb.

"We saw this switching of connectivity happening throughout the basal ganglia and impacting many different body parts," said West. "In some cases these neurons would affiliate with more than one cluster, making accurate response to stimulation, such as touch, almost impossible."

According to West, this connection switching appears permanent, with these changes still evident up to a year after dopamine loss. "These switched connections may explain why L-DOPA and other drugs are unable to restore complex sensorimotor behaviors such as maintaining manual contact with an unseen moving object."

Although conducted with animal models, West's research is applicable to Parkinson's disease in humans. "Human studies of the basal ganglia show overlapping areas that control leg and arm movements organized similarly to rats, which means it is possible for connections to get switched in the human brain just as in the rat brain."

West's results are also consistent with previous studies that have shown that loss of dopamine in humans and animals causes the cortex to sprout new connections to the basal ganglia.

"These kinds of changes in connections would essentially make curing Parkinson's disease difficult or impossible," he explained.

West hopes his findings, which show apparently permanent changes caused by the loss of dopamine to the brain, will encourage more research focused not only on treating, but also preventing, Parkinson's disease.


'"/>

Contact: Stacey Hersh
shersh@ur.rutgers.edu
732-932-7084
Rutgers, the State University of New Jersey
3-Sep-2002


Page: 1 2

Related medicine news :

1. Rutgers College of Nursing faculty member is funded to develop an interactive computer system
2. Rutgers-Newark researchers link early movement, brain development
3. Rutgers-developed biomaterial drives a technology transfer story toward success
4. Rutgers scientists pinpoint brain cells involved in drug addiction relapse
5. Rutgers researcher: Brains in dyslexic children can be rewired to improve reading skills
6. Rutgers study shows learning ability under stress still strong in Prozac-treated females
7. Rutgers wins funds to create online index of moving brain images
8. Rutgers research shows caffeine may prevent skin cancer
9. Rutgers announces Robert Wood Johnson Foundation Investigator Awards in Health Policy Research
10. International Thiamine (Vitamin B-1) Conference at Rutgers Newark
11. Rutgers develops virtual reality treatment for hand impairment in chronic stroke patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, ... Elite. The attorneys chosen by their peers for this recognition are considered among the ... Traurig Shareholders received special honors as members of this year’s Legal Elite Hall of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... York, NY (PRWEB) , ... June 24, 2016 ... ... publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as a ... that “the most beautiful women in the world, and the most handsome men, ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners ... extensive sequencing and genomics experience, as Vice President of North American Capital Sales at ... responsible for leading the sales team in the commercialization of the HTG EdgeSeq system ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
Breaking Medicine Technology:
Cached News: