HOME >> MEDICINE >> NEWS
SSX, a new family of cancer vaccine targets

New York (March) -- Scientists from the Cancer Vaccine Collaborative (CVC) have discovered that the cancer-specific protein, SSX-2, induces a spontaneous immunological reaction against cancer cells in melanoma patients, offering a new target for the development of a therapeutic melanoma vaccine. SSX-2 is the prototype of the SSX family, and is part of a larger group of proteins known as cancer/testis (CT) antigens.

CT proteins are expressed in cancer cells and on normal testes, but the immune system recognizes CT antigens only when they are present on cancer cells. This exquisite immunological specificity for cancer, but not normal, cells has drawn many scientists and clinicians to investigate vaccines against CT antigens as cancer therapies.

"SSX-2 is a particularly good target for a cancer vaccine," says Dr. Danila Valmori, an Assistant Member of the Ludwig Institute for Cancer Research (LICR), and the senior author of the study. "We found that patients are mounting their own immunological responses against cancer cells expressing SSX-2, and although these spontaneously occurring immunological responses are apparently not sufficient for stopping tumor growth, possibly because they develop late in the disease progression, we think that a vaccine that stimulates and amplifies this naturally-occurring attack will have a good chance of giving a clinical response."

The CVC, which was established by the Cancer Research Institute (CRI) and LICR, had previously reported the detection of SSX-2-specific CD8+ T cells and antibodies in patients with melanoma. However, in the report published today in the Journal of Clinical Investigation, they describe the discovery of SSX-2-specific CD4+ T cells, the final member of the immunological triumvirate. Work is underway to characterize the immunogenicity of the other SSX family members, which were originally identified by LICR researchers in New York.

"We believe that for a cancer vaccine to be effect
'"/>

Contact: Sarah L. White, Ph.D.
swhite@licr.org
212-450-1543
Ludwig Institute for Cancer Research
15-Apr-2004


Page: 1 2

Related medicine news :

1. UNC study: Most N.C. family practitioners engage in unrecognized community service
2. Cardiology losing out as women turned off by family unfriendly specialty
3. Olson family donates $1 million to Arizona Cancer Center
4. Mayo Clinic finds restless legs syndrome in children linked to family history, iron deficiency
5. International study provides culture-by-culture clues to family violence and abuse
6. University of Utah vision researchers identify genetic cause of rare eye disease in Utah family
7. Regular family meals promote healthy eating habits
8. Urinary incontinence runs in the family
9. Tumor suppressor gene family may be key to new colon cancer drugs
10. Parent, guardian job loss may boost smoking among adolescent family members
11. Men with family history of prostate cancer accurately predict higher risk, UMHS study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... ... November 19, 2019 , ... Bright Day Big Blocks, http://www.brightdaybigblocks.com , inventors ... launch of their Gift Of Play initiative. Organizations are encouraged to simply make ... of Bright Day Big Blocks, Laurel Tucker and David Krishock decided earlier this year ...
(Date:11/19/2019)... ... November 19, 2019 , ... After the closure of the 208-bed ... conduct an auction of the medical assets. A “decline in community demand” ultimately brought ... An array of high-end equipment ranging from hospital beds to radiology makes this is ...
(Date:11/19/2019)... VEGAS (PRWEB) , ... November 18, 2019 , ... ... on Human Organ Specific Biomarkers.” by Vicki Kindy has been named No. 1 ... Holistic Medicine, Mind-Body Connection, Biochemistry, Laboratory Science, Energy Healing, Nosology, and Alternative Medicine. ...
(Date:11/16/2019)... ... November 15, 2019 , ... At their 36th Annual Awards Gala on November ... $750,000 for programs and services benefiting Calvary patients and their families. Ryan Field, WABC-TV ... from The Chiffons, and Shirley Alston Reeves, original lead singer of The Shirelles. ...
(Date:11/16/2019)... Texas (PRWEB) , ... November 15, 2019 , ... ... older adults living with memory impairment, has announced the Best Memory Care Facilities ... access to experts, facility features and amenities. , According to the ...
Breaking Medicine News(10 mins):
(Date:11/19/2019)... SANTA ROSA, Calif. (PRWEB) , ... November 19, 2019 , ... ... time; however growers in the commercial space have been transitioning to powdered nutrients because ... suit as well. Due to the difficulty in combining essential macro and micronutrients, most ...
(Date:11/19/2019)... ... , ... Dr. David Stoker recently welcomed Carla Crespo, MSHS, PA, to his ... and body contouring procedures is recognized nationally, as she is a premier instructor for ... exclusive group of experts in the U.S. who train injectors for Allergan and Galderma," ...
(Date:11/19/2019)... ... 2019 , ... “Evaluation of the Biofield Energy Treated Novel Test Formulation on ... International Best Seller on Amazon in many categories including Holistic Medicine, Mind-Body Connection, Internal ... Release in Holistic Medicine. , The aim of Suzuki’s research was to ...
Breaking Medicine Technology:
Cached News: